Use of Gas Expanded Liquids to Facilitate Process Intensification. The aim of this research is the utilisation of gas expanded liquids (GXLs) in technology platforms based on the principles of process intensification (PI). In order to facilitate the attainment of project objectives a comprehensive investigation of the fundamental properties of GXLs, and their interactions is proposed. A significant component of the programme is expected to be to use the knowledge obtained to facilitate the devel ....Use of Gas Expanded Liquids to Facilitate Process Intensification. The aim of this research is the utilisation of gas expanded liquids (GXLs) in technology platforms based on the principles of process intensification (PI). In order to facilitate the attainment of project objectives a comprehensive investigation of the fundamental properties of GXLs, and their interactions is proposed. A significant component of the programme is expected to be to use the knowledge obtained to facilitate the development of scale-up protocol for PI based methodologies, with particular emphasis on the production of biomaterials. GXLs technology is frontier technology with regard to the biomaterials sector.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100082
Funder
Australian Research Council
Funding Amount
$408,000.00
Summary
Nanostructures derived from metal-organic frameworks for sodium-ion batteries. This project aims to overcome poor reaction kinetics and the lack of effective anode materials owing to the large size of sodium-ions in high performance sodium-ion batteries. The project will explore a series of functional nanomaterials with unique nanostructures and complex compositions, enabled by metal-organic framework assisted synthetic methods. High performance sodium ion batteries are demonstrating great poten ....Nanostructures derived from metal-organic frameworks for sodium-ion batteries. This project aims to overcome poor reaction kinetics and the lack of effective anode materials owing to the large size of sodium-ions in high performance sodium-ion batteries. The project will explore a series of functional nanomaterials with unique nanostructures and complex compositions, enabled by metal-organic framework assisted synthetic methods. High performance sodium ion batteries are demonstrating great potential to meet the future demand for large-scale and low-cost stationary energy storage. However, their practical implementation is still hindered by their poor reaction kinetics and the lack of effective anode materials owing to the large size of sodium-ions. The project outcomes will promote the commercialisation of sodium ion batteries and power Australia’s sustainable economy in the long run.Read moreRead less
Developing novel aerosol inhalers for pulmonary drug delivery from the fundamental understanding of powder dispersion mechanisms. The project seeks to understand how powder aerosol inhalers can be significantly improved. The outcome will provide therapeutic benefits to the Australian community for better treatment of respiratory diseases and facilitate environmentally friendly technology since these inhalers do not require any harmful organic solvents to operate.
Enabling aerosol delivery of phages to defeat antibiotic-resistant bacteria. This project aims to explore the use of bacteriophages towards producing a safe, natural, and highly effective alternative to traditional antibiotics. Respiratory infections caused by multidrug-resistant Gram-negative bacteria are a major health problem worldwide, and cost Australia over $150 million annually. Some 5,000 Australians die each year from antibiotic resistant infections. The project aims to produce efficac ....Enabling aerosol delivery of phages to defeat antibiotic-resistant bacteria. This project aims to explore the use of bacteriophages towards producing a safe, natural, and highly effective alternative to traditional antibiotics. Respiratory infections caused by multidrug-resistant Gram-negative bacteria are a major health problem worldwide, and cost Australia over $150 million annually. Some 5,000 Australians die each year from antibiotic resistant infections. The project aims to produce efficacious and stable formulations of bacteriophages for easy delivery by inhalation as aerosols with a long shelf-life, making them a commercially viable product. The expected research outcome can lead to an economic and efficient technology to produce phage powders for novel treatment strategies of infections by inhalation.Read moreRead less
Bubble Dynamics in Fine Droplets: Behaviour and Control. The principal vision in this project is to gain a deeper understanding of the formation, growth and collapse of bubbles within micron-size droplets and, in doing so, provide the technical underpinning necessary to advance the development of a range of emerging technologies in the light alloys manufacturing, atomisation, non-invasive medical therapy, drug delivery, and nucleation / solidification in thermal energy storage systems. Expected ....Bubble Dynamics in Fine Droplets: Behaviour and Control. The principal vision in this project is to gain a deeper understanding of the formation, growth and collapse of bubbles within micron-size droplets and, in doing so, provide the technical underpinning necessary to advance the development of a range of emerging technologies in the light alloys manufacturing, atomisation, non-invasive medical therapy, drug delivery, and nucleation / solidification in thermal energy storage systems. Expected outcomes include new experimental evidence and validated mathematical models for the analysis of bubbles encapsulated by fine droplets. The outcomes should significantly enhance Australia’s research and innovation capacity in the field of confined space bubble dynamics and related industrial applications. Read moreRead less
The role of electrostatic charge in airway deposition of aerosols. This project aims to unravel the importance of electrostatic charge in controlling deposition of aerosols in the respiratory tract. The expected outcome is a validated mathematical model for accurately predicting deposition behaviour of charged aerosol particles in human airways. Findings may ultimately be used to underpin novel prevention measures to reduce lung deposition of inhaled hazardous airborne particles to significantly ....The role of electrostatic charge in airway deposition of aerosols. This project aims to unravel the importance of electrostatic charge in controlling deposition of aerosols in the respiratory tract. The expected outcome is a validated mathematical model for accurately predicting deposition behaviour of charged aerosol particles in human airways. Findings may ultimately be used to underpin novel prevention measures to reduce lung deposition of inhaled hazardous airborne particles to significantly reduce health risks and costs. They may also be used to enable the development of new inhalation technologies based on electrostatic charge to improve aerosol drug delivery to the lungs of patients with respiratory diseases.Read moreRead less
Production of nano-composite particles for inhalational delivery of combination drugs. The project seeks to create a new particle engineering process for pharmaceuticals. The successful outcome will i) enhance substantially the competitiveness of Australia’s research in functional nanomaterials and advanced biomaterials, and ii) benefit the Australian pharmaceutical industry in developing proprietary pharmaceutical formulations.
Novel nano-composite particles for controlled-release drugs via inhalation. This project will explore a novel nano-medicine technology using nanocrystals in liposomes to design new composite particles to enable optimal release of antibiotics delivered by inhalation. Respiratory infection caused by multidrug-resistant bacteria is a major health problem worldwide. Controlled-release products using liposomes simplify dose regimen and enhance bacterial killing. Currently, aerosolised liposomes are l ....Novel nano-composite particles for controlled-release drugs via inhalation. This project will explore a novel nano-medicine technology using nanocrystals in liposomes to design new composite particles to enable optimal release of antibiotics delivered by inhalation. Respiratory infection caused by multidrug-resistant bacteria is a major health problem worldwide. Controlled-release products using liposomes simplify dose regimen and enhance bacterial killing. Currently, aerosolised liposomes are limited to liquid forms with limited control over release and stability. The project will provide new technology on manufacturing composite powders of antibiotics that may ultimately lead to the development of effective new treatments against drug-resistant bacteria.Read moreRead less
Modelling of Slug Pneumatic Conveying with an In-situ Microprobe Sensor. This project aims to develop a particle-scale microprobe to capture the transient dynamics of particle behaviours for pneumatic conveying. Slug flow pneumatic transport of granular materials such as mineral particles and food grains is extremely popular across the processing industry. However, without the fundamental understanding of the conveying mechanism at the particulate level, pneumatic conveyors are over-designed and ....Modelling of Slug Pneumatic Conveying with an In-situ Microprobe Sensor. This project aims to develop a particle-scale microprobe to capture the transient dynamics of particle behaviours for pneumatic conveying. Slug flow pneumatic transport of granular materials such as mineral particles and food grains is extremely popular across the processing industry. However, without the fundamental understanding of the conveying mechanism at the particulate level, pneumatic conveyors are over-designed and energy intensive. The project aims to enable accurate measurement of the motion, inertia and force information at the particle scale, so as to produce more accurate design protocols for such a conveying system. Improved pneumatic conveyors may have the potential to reduce the energy consumption in such systems by up to a factor of 10.Read moreRead less
Modelling and characterisation of biomass materials for pneumatic transport. This project aims to develop a particle scale microprobe to capture the transient dynamics of biomass compaction, dilation and associated airflow for pneumatic conveying and potentially beyond. Low velocity, dense phase pneumatic transport presents the ideal method for transporting delicate biomass feedstocks. However, without the fundamental understanding of the compactive and dilative response of biomass ensembles, pn ....Modelling and characterisation of biomass materials for pneumatic transport. This project aims to develop a particle scale microprobe to capture the transient dynamics of biomass compaction, dilation and associated airflow for pneumatic conveying and potentially beyond. Low velocity, dense phase pneumatic transport presents the ideal method for transporting delicate biomass feedstocks. However, without the fundamental understanding of the compactive and dilative response of biomass ensembles, pneumatic conveyors will be over-designed and energy intensive. This project will enable accurate measurement of the motion, inertia and force information at the particle scale, to produce more accurate design protocols for dense phase biomass pneumatic transport.Read moreRead less