Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Powder blending for dry powder inhalers: a new approach for direct control of powder structure. Over 80 per cent of pharmaceutical products involve the processing of powders. This project will generate new knowledge of how to assemble fine and cohesive particles into the structure required for dry powder inhaler products, leading to the development of new low-cost medicines in Australia and the Asia Pacific region.
Controlling hydrate slurry flow to enable deepwater oil and gas production. This project aims to investigate the plugging of hydrate slurries in pipelines to determine under what conditions they will flow satisfactorily without forming a blockage. Hydrate blockages are expensive and hazardous occurrences in oil and gas operations, so current prevention systems aim to avoid hydrate formation altogether through over-design. These over-designed hydrate prevention systems are extremely expensive to ....Controlling hydrate slurry flow to enable deepwater oil and gas production. This project aims to investigate the plugging of hydrate slurries in pipelines to determine under what conditions they will flow satisfactorily without forming a blockage. Hydrate blockages are expensive and hazardous occurrences in oil and gas operations, so current prevention systems aim to avoid hydrate formation altogether through over-design. These over-designed hydrate prevention systems are extremely expensive to build and costly to run during the operations phase. The project intends to examine the behaviour of hydrate slurry flow as a function of the oil's properties, amount of water and degree of turbulence. Outcomes are intended to be a sophisticated approach to avoiding hydrate blockages that is safe but more efficient and less costly.Read moreRead less
Improving the scale-up of spray drying for bioactive extracts and fibres. The project will develop new processing techniques that will contribute to better functional foods and bioactive products from fruit and vegetable wastes. The total national crop of fruit and vegetables produces over 3 million tonnes of wastes, where the bioactive materials in the wastes have a potential value of $3 billion/year.
Granular dynamics: characterization, modelling and application. Storage and transport of bulk solids are widely encountered in mineral, metallurgical and chemical industrials which are important to Australia. The design and control of bulk solids handling equipment must be optimised for the efficiency of processing. This project provides a systematic investigation of the techniques used to characterize bulk solids, and applies the new findings to hopper flow and pneumatic conveying. This, togeth ....Granular dynamics: characterization, modelling and application. Storage and transport of bulk solids are widely encountered in mineral, metallurgical and chemical industrials which are important to Australia. The design and control of bulk solids handling equipment must be optimised for the efficiency of processing. This project provides a systematic investigation of the techniques used to characterize bulk solids, and applies the new findings to hopper flow and pneumatic conveying. This, together with the research training offered through the conduct of the work, is very helpful to maintaining Australia’s leading position in bulk solids handling and application in resource, energy, process and allied industries.Read moreRead less
Design a Targeted Delivery System for Probiotics. The project aims to improve the effectiveness of probiotics by developing a targeted delivery system to the colon. This interdisciplinary research will generate new knowledge in the field of microbiota and develop new delivery systems for live microorganisms and other active compounds. Expected outcomes include increased understanding of the factors affecting the viability of probiotics during storage and passage through the gastro-intestinal tra ....Design a Targeted Delivery System for Probiotics. The project aims to improve the effectiveness of probiotics by developing a targeted delivery system to the colon. This interdisciplinary research will generate new knowledge in the field of microbiota and develop new delivery systems for live microorganisms and other active compounds. Expected outcomes include increased understanding of the factors affecting the viability of probiotics during storage and passage through the gastro-intestinal tract, the establishment of probiotics into gut flora, and how this incorporation affects the dynamics of gut microbiota. The new technology can be utilised across a wide range of therapeutics that target the colon to promote the well-being of our society through commercialisation by industry partner.Read moreRead less
Micromechanical analysis of size segregation and its prediction in granular free-surface flows. Industries often suffer from size segregation in the handling and processing of granular materials, leading to significant economic consequences. This project aims to develop a fundamental understanding of size segregation and prediction models, enabling industries to eliminate, minimise, or manage the effects to an acceptable level.
Gravity Separation and Desliming of Fine Particles. This project will be of benefit to the Australian coal and mineral processing industries, worth tens of billions of dollars to the Australian economy each year. The objective is to establish an innovative system of cascading Reflux Classifiers for achieving both gravity separation and desliming of fine particles. Presently millions of tonnes of fine coal exist in tailings dams, unrecoverable by existing technologies such as flotation. This rese ....Gravity Separation and Desliming of Fine Particles. This project will be of benefit to the Australian coal and mineral processing industries, worth tens of billions of dollars to the Australian economy each year. The objective is to establish an innovative system of cascading Reflux Classifiers for achieving both gravity separation and desliming of fine particles. Presently millions of tonnes of fine coal exist in tailings dams, unrecoverable by existing technologies such as flotation. This research will provide options for the recovery of this resource, making the remediation of these sites economically viable. The project will also support the education and training of researchers in this field of importance to Australia’s future.Read moreRead less
Syngas Production Using Catalytic Carbon Dioxide Dry Reforming. This project intends to pave the way for turning remote low-value Australian resources and greenhouse gases into valuable products. Most of Australian natural gas reserves are located in the remote north-west shelf, and many are small scale and thus cannot be economically harnessed using conventional methods such as pipeline transportation or gas liquefaction. In this project, a dry reforming reactor with novel catalysts will be des ....Syngas Production Using Catalytic Carbon Dioxide Dry Reforming. This project intends to pave the way for turning remote low-value Australian resources and greenhouse gases into valuable products. Most of Australian natural gas reserves are located in the remote north-west shelf, and many are small scale and thus cannot be economically harnessed using conventional methods such as pipeline transportation or gas liquefaction. In this project, a dry reforming reactor with novel catalysts will be designed for converting natural gas and carbon dioxide to syngas, which is an intermediate step of gas-to-liquid plant. By innovatively integrating advanced catalysis and heating technologies, reactor weight and operational costs will be minimised.Read moreRead less
Methanol to diesel. Australia has large remote gas reserves which are not accessible to markets via pipeline and cannot be effectively utilised using liquefied natural gas technology. Fischer-Tropsch conversion of gas to liquid (GTL), being capital intense, is uneconomical for these stranded gas resources. This project will develop a new GTL technology to produce sulphur-free, clean combustion diesel. The outcomes of this research will be a frontier technology that allows more effective utilisat ....Methanol to diesel. Australia has large remote gas reserves which are not accessible to markets via pipeline and cannot be effectively utilised using liquefied natural gas technology. Fischer-Tropsch conversion of gas to liquid (GTL), being capital intense, is uneconomical for these stranded gas resources. This project will develop a new GTL technology to produce sulphur-free, clean combustion diesel. The outcomes of this research will be a frontier technology that allows more effective utilisation of Australian remote gas resources to meet rising global demand for transport fuels, adding enormous value to Australian natural resources and contributing to Building and Transforming Australian industries.Read moreRead less