Combined optical and electrical stimulation of auditory neurons. The bionic ear, which has now helped to improve the hearing of over 200,000 people worldwide, is a great example of Australian innovation success. This project aims to develop the fundamental technology that will underpin the next generation of these devices using a combination of infrared light and electrical signals to stimulate auditory nerves.
Complete blood fractionation using a low-cost microfluidic system. This project aims to understand particle focusing in inertial microfluidic systems to design efficient devices for cell sorting. The field of microfluidics could ultimately advance medical research but device design is primitive. Microfluidic particle separations are not thoroughly simulated before fabrication to predict performance. This project is expected to accelerate progress in design of efficient microfluidic devices. The ....Complete blood fractionation using a low-cost microfluidic system. This project aims to understand particle focusing in inertial microfluidic systems to design efficient devices for cell sorting. The field of microfluidics could ultimately advance medical research but device design is primitive. Microfluidic particle separations are not thoroughly simulated before fabrication to predict performance. This project is expected to accelerate progress in design of efficient microfluidic devices. The knowledge and models developed in this project should help design and develop a microfluidic device for efficient fractionation of complex fluids into valuable components.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100922
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Diamond cybernetics: nanocrystalline diamond for interfacing bionic devices with the human nervous system. Bionic devices will soon be used to treat disorders such as epilepsy, Parkinson's and depression. We will use diamond to create high resolution, permanent electrical connections between devices and the human nervous system. These diamond connections will preserve nerve health and make bionic devices more effective and able to last a lifetime.
Quantitative micro-computed tomography for mechanobiological measurement. This project aims to investigate novel measurement approaches for complex cartilage and joint systems by utilising engineering and software design, imaging physics and musculoskeletal biology. Accurate measurement of these living biological systems in action expects to generate new knowledge and a fundamental understanding of their mechanobiological processes. This project will enhance understanding of this complex system ....Quantitative micro-computed tomography for mechanobiological measurement. This project aims to investigate novel measurement approaches for complex cartilage and joint systems by utilising engineering and software design, imaging physics and musculoskeletal biology. Accurate measurement of these living biological systems in action expects to generate new knowledge and a fundamental understanding of their mechanobiological processes. This project will enhance understanding of this complex system and facilitate our capacity to innovate functional solutions in biomedical engineering and biosciences.Read moreRead less
Three-Dimensional Polymer Fibre Scaffolds with Functional Nano-structured Surface. The Partner Organisation to this research, CyGenics Ltd, is a world leader in cell biotechnology. A key challenge faced by the CyGenics and other biotech companies is the provision of tissue scaffolding materials that have the right three-dimensional macroscopic structure plus a suitable nano-structured surface micro-environment, similar to the natural extracellular matrix. This joint project combines expertise in ....Three-Dimensional Polymer Fibre Scaffolds with Functional Nano-structured Surface. The Partner Organisation to this research, CyGenics Ltd, is a world leader in cell biotechnology. A key challenge faced by the CyGenics and other biotech companies is the provision of tissue scaffolding materials that have the right three-dimensional macroscopic structure plus a suitable nano-structured surface micro-environment, similar to the natural extracellular matrix. This joint project combines expertise in polymer fibres, surface engineering and cell culture to tackle the key challenge. The outcome will help position the local polymer fibre and cell culture industries at the forefront of tissue scaffolding materials research and development. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100175
Funder
Australian Research Council
Funding Amount
$347,070.00
Summary
Three-dimensional additive bio-fabrication facility: printing bioprinters. This project aims to develop bioprinting systems that will provide new insights into fundamental biological processes. The 3D Additive Bio-Fabrication Facility - Printing Bioprinters capability will use 3D polymer and metal additive manufacturing technologies to create the next generation of bioprinting methodologies and 3D fabrication tools. It is the aim that these customised additive manufacturing systems will be used ....Three-dimensional additive bio-fabrication facility: printing bioprinters. This project aims to develop bioprinting systems that will provide new insights into fundamental biological processes. The 3D Additive Bio-Fabrication Facility - Printing Bioprinters capability will use 3D polymer and metal additive manufacturing technologies to create the next generation of bioprinting methodologies and 3D fabrication tools. It is the aim that these customised additive manufacturing systems will be used to produce structures wherein living cells are spatially organised in combination with appropriate biomaterials and bioactive components, such as drugs or growth factors, in order to influence subsequent biological behaviour.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100302
Funder
Australian Research Council
Funding Amount
$461,300.00
Summary
A long-lasting interface for communicating with the brain. This project aims to address the most urgent challenges in developing the next generation of implantable devices for communicating with the brain. Using a new type of carbon-based electrode, along with light therapy, this project expects to build innovative technologies that can greatly enhance the functionality and longevity of these devices. Expected outcomes include a novel tool that can be implemented to obtain detailed insights into ....A long-lasting interface for communicating with the brain. This project aims to address the most urgent challenges in developing the next generation of implantable devices for communicating with the brain. Using a new type of carbon-based electrode, along with light therapy, this project expects to build innovative technologies that can greatly enhance the functionality and longevity of these devices. Expected outcomes include a novel tool that can be implemented to obtain detailed insights into neural circuits, advancing our understanding of neural function and pioneering feedback and closed-loop neuroscience. This project should provide significant benefits in neuroscience research and the neural interface industry, both of which have the ultimate goal to unlock the mysteries of the brain.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100909
Funder
Australian Research Council
Funding Amount
$425,523.00
Summary
3D micro-bioprinting: acoustic actuation to shape single-cell organization. This project aims to develop an innovative cell-printing technology to replicate the microscale cell structure found in native human and animal tissues. This is based on an interdisciplinary concept that combines ultra-high frequency acoustic cell manipulation with 3D stereolithography printing, and will examine acoustic waveguide element design and their topological optimisation. In contrast to current 3D printing metho ....3D micro-bioprinting: acoustic actuation to shape single-cell organization. This project aims to develop an innovative cell-printing technology to replicate the microscale cell structure found in native human and animal tissues. This is based on an interdisciplinary concept that combines ultra-high frequency acoustic cell manipulation with 3D stereolithography printing, and will examine acoustic waveguide element design and their topological optimisation. In contrast to current 3D printing methods that are not suitable for precisely integrating microscale elements in the printing process, this work will open up the range of materials, including functional human tissues, that can be printed.Read moreRead less
Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineerin ....Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineering.Read moreRead less
New entropy measures of short term signals for smart wearable devices. This project aims to improve reliability and accuracy of wearable devices by developing a new set of computationally efficient algorithms. Wearable devices can be very effective in remote and continuous monitoring to detect short or bursty anomalous events. Present devices are unable to detect such events effectively due to limited capability in processing short length signal. This project will provide computationally efficie ....New entropy measures of short term signals for smart wearable devices. This project aims to improve reliability and accuracy of wearable devices by developing a new set of computationally efficient algorithms. Wearable devices can be very effective in remote and continuous monitoring to detect short or bursty anomalous events. Present devices are unable to detect such events effectively due to limited capability in processing short length signal. This project will provide computationally efficient algorithms for signal quality analysis and enhanced feature extraction methods in resource constrained wearable devices. This will improve the reliability and performance of wearable devices for adoption in intelligent decision-making systems.Read moreRead less