Identifying Target Genes For Novel Anti-epileptic Therapies In The Mouse
Funder
National Health and Medical Research Council
Funding Amount
$469,802.00
Summary
Epilepsy is a disease which affects 2-4% of the population. There are a wide range of drugs available to treat the condition but there is consistently 30-40% of patients who do not respond well to any of these drugs and who continue to have seizures. The reason that there are no drugs available for these people is that most of the drugs available have been designed along the same principles. A new set of principles is needed to develop new drugs which will be able to treat those people not respo ....Epilepsy is a disease which affects 2-4% of the population. There are a wide range of drugs available to treat the condition but there is consistently 30-40% of patients who do not respond well to any of these drugs and who continue to have seizures. The reason that there are no drugs available for these people is that most of the drugs available have been designed along the same principles. A new set of principles is needed to develop new drugs which will be able to treat those people not responding to current therapy. This project is designed to identify new biologic pathways which may be interrupted with drugs to prevent seizures in people with epilepsy. This project uses a procedure to induce mutations into genes in mice and then screens for mice which do not seize when challenged with a drug which generates seizures in mice. Genetic studies will identify the mutated genes and these will be used as potential targets for new therapies or will identify new biological pathway which should expand the use of future anti-epileptic drugs.Read moreRead less
Understanding marine biodiversity across vast spatial scales. Large-scale studies of biodiversity are frequently recommended by ecologists, but their costs are prohibitive. More efficient, yet accurate, sampling and analytical procedures are needed. This proposal will provide new quantitative knowledge on patterns of diversity of marine species (fish & invertebrates) from local to regional scales across southern Australia and northern New Zealand. An innovative feature of this research is the c ....Understanding marine biodiversity across vast spatial scales. Large-scale studies of biodiversity are frequently recommended by ecologists, but their costs are prohibitive. More efficient, yet accurate, sampling and analytical procedures are needed. This proposal will provide new quantitative knowledge on patterns of diversity of marine species (fish & invertebrates) from local to regional scales across southern Australia and northern New Zealand. An innovative feature of this research is the contribution of new ecological information with novel analytical procedures to identify the consequences of using more cost-effective techniques on quantifying patterns of biodiversity. This understanding is fundamental to the on-going advancement of ecology and conservation biology.Read moreRead less
Forecasting change in subtidal habitats: connecting local pollution with global climate in temperate Australia. The current narrow focus of management on local and contemporary environmental conditions (e.g. water quality) has indeterminate outcomes in the face of climate change. This proposal seeks to forecast marine habitats under realistic scenarios of climate change and continuing local population growth and activity. This information provides managers with information needed to understand t ....Forecasting change in subtidal habitats: connecting local pollution with global climate in temperate Australia. The current narrow focus of management on local and contemporary environmental conditions (e.g. water quality) has indeterminate outcomes in the face of climate change. This proposal seeks to forecast marine habitats under realistic scenarios of climate change and continuing local population growth and activity. This information provides managers with information needed to understand the consequences of current policy and debates about its improvement.Read moreRead less
The interplay between natural and human perturbations in structuring marine habitats. Empirical predictions of which could be the changes to natural habitats caused by human perturbations will increase the ability to prevent irreversible losses of biodiversity. This project will enable the planning of sound strategies for the conservation of valuable ecosystems, such as kelp forests, in view of the massive changes that will likely take place as a consequence of increasing exploitation of marine ....The interplay between natural and human perturbations in structuring marine habitats. Empirical predictions of which could be the changes to natural habitats caused by human perturbations will increase the ability to prevent irreversible losses of biodiversity. This project will enable the planning of sound strategies for the conservation of valuable ecosystems, such as kelp forests, in view of the massive changes that will likely take place as a consequence of increasing exploitation of marine resources and of global climatic changes. The scientific knowledge generated by this project is necessary for a sustainable development of coastal areas, which would guarantee the provision of goods and services to Australian future generations.Read moreRead less
Local and regional investigations into perturbations of marine habitat. Surprising changes to coastal ecology are forecast as increasing physical stresses (e.g. nutrient and sediment runoff) initiate changes to habitat. Lack of information about perturbations remains a major gap in marine ecology and coastal management. Multifactorial experiments will examine perturbations to one of temperate Australia's most widespread subtidal habitats (kelp forests) to test predictions derived from ecologic ....Local and regional investigations into perturbations of marine habitat. Surprising changes to coastal ecology are forecast as increasing physical stresses (e.g. nutrient and sediment runoff) initiate changes to habitat. Lack of information about perturbations remains a major gap in marine ecology and coastal management. Multifactorial experiments will examine perturbations to one of temperate Australia's most widespread subtidal habitats (kelp forests) to test predictions derived from ecological theory. Tests focus on (1) models about abrupt switches of habitat to contrasting states, and (2) responses among regions bearing striking differences in consumer control. These trans-Australian tests may change the way we view one of the world's most extensive temperate coastlines.Read moreRead less
Managing Australia's unique south coast. Innovative coastal management based on sound ecological understanding is a pressing issue in state and federal government. A federal initiative seeks integration of marine protected areas with other spatial arrangements for conservation of biodiversity. This proposal will inform the forthcoming selection of marine protected areas in South Australia. Significantly, it assesses whether adjacent land-use (natural vegetation, urbanisation, agriculture) can ....Managing Australia's unique south coast. Innovative coastal management based on sound ecological understanding is a pressing issue in state and federal government. A federal initiative seeks integration of marine protected areas with other spatial arrangements for conservation of biodiversity. This proposal will inform the forthcoming selection of marine protected areas in South Australia. Significantly, it assesses whether adjacent land-use (natural vegetation, urbanisation, agriculture) can enhance or compromise the utility of marine protected areas as a biodiversity repository.
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Dispersal and gene flow in habitat-forming algae. The temperate coast of Australia has a unique and diverse algal flora. Many of these algae play a central role in subtidal ecology by providing habitat to an astonishing diversity of taxa. Despite this, we have no understanding of levels of gene flow within and among populations of habitat forming algae or how such populations persist in nature. By addressing this lack of knowledge, my research will contribute information that is critical for the ....Dispersal and gene flow in habitat-forming algae. The temperate coast of Australia has a unique and diverse algal flora. Many of these algae play a central role in subtidal ecology by providing habitat to an astonishing diversity of taxa. Despite this, we have no understanding of levels of gene flow within and among populations of habitat forming algae or how such populations persist in nature. By addressing this lack of knowledge, my research will contribute information that is critical for the conservation and management of algal habitats. This is particularly pertinent because anthropogentic stressors are beginning to precipitate significant changes in algal forests along Australia's coastline. Read moreRead less
Diatom frustules: nanostructures at the base of ocean food webs. Molecules interacting with surfaces are fundamental to biological, chemical and physical processes, including desalinization membrane design, lab-on-a-chip systems, industrial catalysis, bioremediation, neurophysiology and uptake of nutrients for incorporation into food webs. Here, we use diatoms as models for molecule-surface interactions to find basic principles that underlay all of these interactions. This research will train st ....Diatom frustules: nanostructures at the base of ocean food webs. Molecules interacting with surfaces are fundamental to biological, chemical and physical processes, including desalinization membrane design, lab-on-a-chip systems, industrial catalysis, bioremediation, neurophysiology and uptake of nutrients for incorporation into food webs. Here, we use diatoms as models for molecule-surface interactions to find basic principles that underlay all of these interactions. This research will train students and scientists and establish collaborations with leading international scientists in the field.Read moreRead less
Estimating fishing-related mortality and designing sustainable management protocols for shark fisheries in Northern Australia. Sharks are extremely valuable economically, with the landed catch in the NT alone exceeding $10 million in 2004. The increasing world demand for high-quality protein will necessitate appropriate management so that over-exploitation does not occur as it has in most other shark fisheries worldwide. The proposed project will provide key information that will direct careful ....Estimating fishing-related mortality and designing sustainable management protocols for shark fisheries in Northern Australia. Sharks are extremely valuable economically, with the landed catch in the NT alone exceeding $10 million in 2004. The increasing world demand for high-quality protein will necessitate appropriate management so that over-exploitation does not occur as it has in most other shark fisheries worldwide. The proposed project will provide key information that will direct careful and informed management decisions well into the future. The added benefit of collecting information on the rarer and more susceptible non-target species caught in this fishery will ensure that any negative impacts are reduced. The project will also provide information on the potential impact of illegal fishing by neighbouring countries to our north.Read moreRead less
Physical and Ecological Structure at the Base of Ocean Food Webs. The coastal ocean is a crucial resource to Australia. In founding a research area on coastal food web function we provide international scientific leadership, train scientists in a cutting edge area, and lay the foundation for improved management of fisheries, aquaculture and species invasions. This work boosts Australia's participation in the International Polar Year, and knowledge about Antarctic Territorial waters. Infrastructu ....Physical and Ecological Structure at the Base of Ocean Food Webs. The coastal ocean is a crucial resource to Australia. In founding a research area on coastal food web function we provide international scientific leadership, train scientists in a cutting edge area, and lay the foundation for improved management of fisheries, aquaculture and species invasions. This work boosts Australia's participation in the International Polar Year, and knowledge about Antarctic Territorial waters. Infrastructure benefit comes from the French government paying for an outstanding French scientist to come to Australia 6 months/yr for 5 yrs. This grant acts as the base for larger projects that import EU and American funds.Read moreRead less