Mechanisms of action and expression of bioactive compounds produced by the surface associated marine bacterium Pseudoalteromonas tunicata. The marine surface-associated bacterium Pseudoalteromonas tunicata produces a number of bioactive metabolites that inhibit the colonisation and growth of common fouling organisms such as bacteria, fungi, algae and invertebrate larvae. The antibacterial and antifungal compounds represent novel metabolites active against a remarkable range of both medically and ....Mechanisms of action and expression of bioactive compounds produced by the surface associated marine bacterium Pseudoalteromonas tunicata. The marine surface-associated bacterium Pseudoalteromonas tunicata produces a number of bioactive metabolites that inhibit the colonisation and growth of common fouling organisms such as bacteria, fungi, algae and invertebrate larvae. The antibacterial and antifungal compounds represent novel metabolites active against a remarkable range of both medically and agriculturally important bacteria and fungi. This project aims to explore the identity, mode of action and regulation of expression of these compounds. This research proposal addresses several significant biological concepts and will lead to the development of novel environmentally friendly antifouling and antimicrobial technologies.Read moreRead less
Environmental genomics and novel bioactives from microbial communities on living marine surfaces. This project has three linked benefits to Australia. One, it is the first study to use environmental genomics analysis in an Australian marine ecosystem, thus bringing into the Australian scientific community the cutting edge technology for studying diverse microbial communities. Two, by using this technology we will be able to investigate Australian marine biodiversity to an unprecedented extent. ....Environmental genomics and novel bioactives from microbial communities on living marine surfaces. This project has three linked benefits to Australia. One, it is the first study to use environmental genomics analysis in an Australian marine ecosystem, thus bringing into the Australian scientific community the cutting edge technology for studying diverse microbial communities. Two, by using this technology we will be able to investigate Australian marine biodiversity to an unprecedented extent. Three, this newly revealed diversity will then be mined for novel bioactives for use in pharmaceutical and other human health applications. Read moreRead less