Validation Of A Multiplexed Blood Based Screening Assay For The Diagnosis Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$556,712.00
Summary
Colorectal cancer (CRC) is the second most common cancer in Australia with poor patient outcome due to late detection of the disease. We have developed a simple blood based test that can diagnose individuals with CRC at an early stage when the chance of cure is greater than 80%.
Learning Software Security Analysers with Imperfect Data. This project aims to systematically investigate next-generation learning-based software security analysis to detect vulnerabilities in real-world large-scale software. The expected learning-based foundation will support the handling of imperfect data in order to provide a precise, scalable and adaptive security analysis of the critical software components, thus capturing important security vulnerabilities missed by existing approaches. Th ....Learning Software Security Analysers with Imperfect Data. This project aims to systematically investigate next-generation learning-based software security analysis to detect vulnerabilities in real-world large-scale software. The expected learning-based foundation will support the handling of imperfect data in order to provide a precise, scalable and adaptive security analysis of the critical software components, thus capturing important security vulnerabilities missed by existing approaches. The success of this project will further enhance the international competitiveness of Australian research in this important field and will benefit any Australian industry and business where software systems are deeply-rooted, such as transportation, smart homes, medical devices, defence and finance.Read moreRead less
The Use Of MicroRNA As Novel Therapeutic Targets For Reducing Retinal Inflammation And Degeneration
Funder
National Health and Medical Research Council
Funding Amount
$349,076.00
Summary
Age-Related Macular Degeneration (AMD) is the most common cause of blindness in Australia. We aim to investigate a new class of potential therapeutics, microRNA which are involved in the regulation of many biological processes, including inflammation. A greater understanding of these miRNA will enable discovery of novel therapeutic targets for inflammatory diseases like AMD, and will have further reaching applications in other inflammatory disease such as Alzheimer’s and Parkinson’s.
Implementation Of Dynamic Reference Points And Harvest Strategies To Account For Environmentally-driven Changes In Productivity In Australian Fisheries
Funder
Fisheries Research and Development Corporation
Funding Amount
$552,027.00
Summary
Recently, the risks resulting from not accounting for variability in productivity have become translated into potential risks associated with environmentally driven trends in recruitment, particularly the risk created by ongoing declines in recruitment (and/or growth) driven by climate-change induced trends in water temperature, weather and current patterns.
A number of southeast Australia fish stocks have failed to 'recover' following substantial reductions in catch and effort, and a n ....Recently, the risks resulting from not accounting for variability in productivity have become translated into potential risks associated with environmentally driven trends in recruitment, particularly the risk created by ongoing declines in recruitment (and/or growth) driven by climate-change induced trends in water temperature, weather and current patterns.
A number of southeast Australia fish stocks have failed to 'recover' following substantial reductions in catch and effort, and a number of research projects have concluded that some of these have undergone an environmentally-driven reduction in productivity. A productivity shift has already been demonstrated for Eastern Jackass Morwong, with the stock-recruit relationship and reference points being adjusted to reflect this change. Ecosystem and climate-change modelling have predicted increasing likelihood of similar changes in productivity for a number of Australian fish stocks.
Current harvest strategies assume either equilibrium or some average B0, and associated target (B48) and limit (B20) reference points. Use of equilibrium B0-based reference points and harvest strategies do not correctly reflect the natural dynamics of stocks where productivity changes. This can lead to sub-optimal management, either over-utilising a reduced productivity stock or under-utilising an increased productivity stock. In contrast, reference points based on some proportion of naturally variable unfished biomass (Bunfished or dynamic B0) will fluctuate to follow environmentally-driven productivity changes. Dynamic reference points have been evaluated and adopted for a number of international fisheries.
The need to adapt stock assessment methods and harvest strategies to explicitly and justifiably account for shifts in productivity has been recognised by the AFMA Resource Assessment Group for the Southern and Eastern Scalefish and Shark Fishery (SESSF), not least as a result of clearly evident declines in biomass (Jackass Morwong, Redfish) or recruitment (Silver Warehou) that cannot be attributed to fishing under current productivity assumptions.
Objectives: 1. To review relevant international research and management approaches to account for environmentally-driven productivity change in stock assessments, reference points and harvest strategies for selected Australian fish stocks. 2. To identify and describe circumstances and fish stocks for which dynamic reference points should or should not be used in stock assessments and harvest strategies, and develop appropriate methodology for conducting assessments using dynamic reference points. 3. To identify selected candidate fish stocks showing likely environmentally-driven productivity change, conduct comparative assessments for these stocks using equilibrium and dynamic reference points, and prepare a candidate harvest strategy that includes dynamic reference points for testing in the FRDC Multi-Species Harvest Strategy project. 4. To make recommendations on future implementation of dynamic reference points and harvest strategies for Australian fish stocks. 5. To develop and improve methods for detecting and quantifying changes in productivity (growth and recruitment) in stock assessments, to relate these to environmental mechanisms causing productivity changes, and to evaluate data needs, including environmental indices, required to usefully detect and evaluate productivity change under various circumstances. 6. To consider and evaluate options for effective harvest control rules, incorporating dynamic reference points, that might appropriately respond to changes in fish stock productivity, including environmentally driven trends in productivity. 7. To identify environmental circumstances and fish stock characteristics under which it would be appropriate and advisable to move to using assessments and management approaches incorporating dynamic productivity and reference points, vs. stocks for which dynamic approaches offer no benefit compared to existing equilibrium approaches. 8. To make recommendations on future stock assessment approaches, data requirements, harvest control rules and management approaches incorporating environmental indicators, dynamic productivity and dynamic reference points for Australian fish stocks. Read moreRead less
Discovery Indigenous Researchers Development - Grant ID: DI100100130
Funder
Australian Research Council
Funding Amount
$180,834.00
Summary
Developing predictive tools for rapid assessment of multiple impacts, including climate change, on the marine ecosystem of Torres Strait (Australia). This project will underpin Australia's long-term commitment to maintain environmental biodiversity and sustainability in the face of synergistic effects from multiple threats. We will describe the consequences of threats and stressors on marine processes, harvested resources, and ecosystem functioning by identifying vulnerable species and habitats. ....Developing predictive tools for rapid assessment of multiple impacts, including climate change, on the marine ecosystem of Torres Strait (Australia). This project will underpin Australia's long-term commitment to maintain environmental biodiversity and sustainability in the face of synergistic effects from multiple threats. We will describe the consequences of threats and stressors on marine processes, harvested resources, and ecosystem functioning by identifying vulnerable species and habitats. We will provide management advice on balancing cultural and ecosystem integrity, economic efficiency, and ecosystem resilience under scenarios of climate and environmental change. This information is of immediate use by Australian government agencies. The project will put Australian scientists at the forefront of research focused on the adaptation of marine ecosystems to synergistic effects.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237912
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Acoustic tracking key marine species in Tasmania using new technology. We will use new passive listening receivers and uniquely indentifiable acoustic tags to track key marine species (squid, octopus, fish and crustaceans) in Tasmania. This technology allows us to remotely track species with a level of detail previously not available. By using a large number of receivers we will build listening 'curtains'. A series of curtains will then form a multi-species listening grid. This equipment wi ....Acoustic tracking key marine species in Tasmania using new technology. We will use new passive listening receivers and uniquely indentifiable acoustic tags to track key marine species (squid, octopus, fish and crustaceans) in Tasmania. This technology allows us to remotely track species with a level of detail previously not available. By using a large number of receivers we will build listening 'curtains'. A series of curtains will then form a multi-species listening grid. This equipment will allow us to reconstruct movement between habitats, and migration routes to better understand and manage this marine ecosystem. An important feature will involve monitoring organism movements into and out of marine protected areas.Read moreRead less
Impact of increased sediment and nutrient discharges on the long-term sustainability of the Great Barrier Reef. The Great Barrier Reef, one of Australia's greatest natural assets, is under increasing threat from extreme climatic events caused by global warming and from land-based pollution. This research will identify the main sources of sediment and nutrient pollution caused by river runoff and by how much this has increased above 'natural levels'. We will discover how the very sensitive offsho ....Impact of increased sediment and nutrient discharges on the long-term sustainability of the Great Barrier Reef. The Great Barrier Reef, one of Australia's greatest natural assets, is under increasing threat from extreme climatic events caused by global warming and from land-based pollution. This research will identify the main sources of sediment and nutrient pollution caused by river runoff and by how much this has increased above 'natural levels'. We will discover how the very sensitive offshore coral reefs have responded to increased pollution and whether this is the cause of the very devastating crown-of-thorn-starfish infestations. Understanding the long-term effects of land-based pollution on the ecology of coral reefs in the GBR will thus provide a scientific basis to help ensure that it has a sustainable future.Read moreRead less
Using biodiesel cleanup agents to reduce impacts on mangroves and tidal wetland ecosystems from oil spills. This Linkage project will demonstrate Australia's commitment towards minimisation of the ecological impacts of key pollutants like oil in the marine environment. It will also advance Australia's leadership position in the management of oil spill remediation and will, through the robust partnership developed with Australian Maritime Safety Authority build a skilled team better able to respo ....Using biodiesel cleanup agents to reduce impacts on mangroves and tidal wetland ecosystems from oil spills. This Linkage project will demonstrate Australia's commitment towards minimisation of the ecological impacts of key pollutants like oil in the marine environment. It will also advance Australia's leadership position in the management of oil spill remediation and will, through the robust partnership developed with Australian Maritime Safety Authority build a skilled team better able to respond effectively when such disasters occur. The challenge is to maintain this research focus and create some stability and continuity of the knowledge and experiences gained at the University of Queensland. Significantly the project will provide career-oriented research training opportunities in a field that clearly underpins National Research Priorities. Read moreRead less