Targeting The EGFR And C-Met Tyrosine Kinase Receptors In Myeloproliferative Neoplasms
Funder
National Health and Medical Research Council
Funding Amount
$607,559.00
Summary
We propose that in the blood disorders called Myeloproliferative Neoplasms (MPN) there are important changes that affect the function of receptors expressed on the surface of blood cells. These changes will perturb blood cell production and may be able to be targeted effectively with drugs. We will test this using laboratory-based and mouse models of MPN, together with specific drugs that are currently in the clinic, and that inhibit the activity of the key receptors involved. This approach can ....We propose that in the blood disorders called Myeloproliferative Neoplasms (MPN) there are important changes that affect the function of receptors expressed on the surface of blood cells. These changes will perturb blood cell production and may be able to be targeted effectively with drugs. We will test this using laboratory-based and mouse models of MPN, together with specific drugs that are currently in the clinic, and that inhibit the activity of the key receptors involved. This approach can be rapidly translated to clinical trial.Read moreRead less
C-Cbl-directed Leukaemogenesis: The Roles Of Core-Binding Factors And PI 3-kinase Signalling.
Funder
National Health and Medical Research Council
Funding Amount
$636,199.00
Summary
Myeloid leukaemia remains a major health problem with only about one third of patients being cured. More effective treatments are therefore needed. For these treatments to be developed more knowledge is required about the genetic and biochemical changes that cause myeloid leukaemia. This project aims to increase this knowledge by studying how cancer-causing proteins are involved in the development of myeloid leukaemia and how targeting these proteins can be used to develop new treatments.