Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Defining Genetic And Epigenetic Variation During Early Development
Funder
National Health and Medical Research Council
Funding Amount
$996,075.00
Summary
We all began life with a set of genes inherited from our parents. However, it's now known that from the time we were in the womb onwards that genes can be turned off and on by the environment or even completely lost or gained. Even what your mother ate or how she behaved while she was pregnant could have influenced your future health. Because people are so different, we are studying the subtle differences between twins to tease out the factors that may influence our genes and our health.
Authenticity: Globalisation and Indigenous Culture. Who speaks for the Fourth World? Why is there an obsession with 'authenticity' whenever Indigenous people are being discussed? This study explores those questions by examining a combination of sources, ranging from international museum collections to the advertising campaigns of multinational companies; from literature to the cultural festivals of the Olympic Games. The research is original, comparative, empirical. It explores the intersectio ....Authenticity: Globalisation and Indigenous Culture. Who speaks for the Fourth World? Why is there an obsession with 'authenticity' whenever Indigenous people are being discussed? This study explores those questions by examining a combination of sources, ranging from international museum collections to the advertising campaigns of multinational companies; from literature to the cultural festivals of the Olympic Games. The research is original, comparative, empirical. It explores the intersections between postcolonial and cultural studies to speak -- not for Indigenous peoples -- but to the non-Indigenous representation of First Nations. Why? Because this provides key insights into the future of race relations in western democracies.Read moreRead less
Wild Man from Borneo: species, race, representation. This project addresses the representation of species boundaries in Western accounts of the orangutan in the 19th and 20th centuries. Darwinian theory raised the possibility that animals could ?evolve?. Orangutans seemed ?closest? to humans and therefore raised key questions about the border between humans and animals. These questions were addressed in a vast range of scientific, popular, imaginative and juvenile literature. Even when ecolo ....Wild Man from Borneo: species, race, representation. This project addresses the representation of species boundaries in Western accounts of the orangutan in the 19th and 20th centuries. Darwinian theory raised the possibility that animals could ?evolve?. Orangutans seemed ?closest? to humans and therefore raised key questions about the border between humans and animals. These questions were addressed in a vast range of scientific, popular, imaginative and juvenile literature. Even when ecological models of the environment shifted attention from evolutionary potential to ecological role, orangutans retained a special status as ?sentinel? species. This project will produce a monograph examining the construction, maintenance and erosion of ideas of species boundaries.Read moreRead less
Mobile Indonesians: social differentiation and digital literacies in the twenty first century. This is the first dedicated study of the social implications of mobile telephony's recent and rapid popularisation throughout the country. This project will study metropolitan, urban and rural users to understand how mobile phones create the new and unexpected social networks which will shape tomorrow's Indonesians.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100148
Funder
Australian Research Council
Funding Amount
$460,000.00
Summary
TrISMA - Tracking Infrastructure for Social Media Analysis. Tracking infrastructure for social media analysis: The tracking infrastructure for social media analysis (TrISMA) project establishes state-of-the-art technical and organisational infrastructure for the tracking of public communication by Australian users of social media, at large scale, in real time, and for the long term, addressing a significant gap in national research infrastructure. Social media are increasingly embedded in the Au ....TrISMA - Tracking Infrastructure for Social Media Analysis. Tracking infrastructure for social media analysis: The tracking infrastructure for social media analysis (TrISMA) project establishes state-of-the-art technical and organisational infrastructure for the tracking of public communication by Australian users of social media, at large scale, in real time, and for the long term, addressing a significant gap in national research infrastructure. Social media are increasingly embedded in the Australian media ecology, and systematic analyses of how public communication takes place via social media provide rich insights into a range of issues and debates of high importance to our society.Read moreRead less
Anglos Abroad: Memoirs of Immersion in a Foreign Language and Culture. A study of Anglophone narratives of language immersion offers a significant intellectual resource for thinking about ways in which Australian non-immigrant selves are shaped by culture and language: an issue with important implications for just practises within a wide range of national institutions and agencies, including education, immigration and social work. It thus contributes to the priority goal of strengthening Austral ....Anglos Abroad: Memoirs of Immersion in a Foreign Language and Culture. A study of Anglophone narratives of language immersion offers a significant intellectual resource for thinking about ways in which Australian non-immigrant selves are shaped by culture and language: an issue with important implications for just practises within a wide range of national institutions and agencies, including education, immigration and social work. It thus contributes to the priority goal of strengthening Australia's social and economic fabric (Research Priority 2). It also contributes to enhancing our capacity to interpret and engage with our region and the world through a greater understanding of other languages and cultures (Research Priority 4).Read moreRead less
The sexual cultures of Thai men; implications for Australia's international HIV/AIDS strategy. This project contributes to safeguarding Australia's national interests by supporting the implementation of AusAID's international HIV/AIDS strategy laid out in the policy document 'Meeting the Challenge: Australia's International HIV/AIDS Strategy' (2004). This project directly addresses research priorities identified in the analytical report for the White Paper on Australia's AID program, 'HIV/AIDS i ....The sexual cultures of Thai men; implications for Australia's international HIV/AIDS strategy. This project contributes to safeguarding Australia's national interests by supporting the implementation of AusAID's international HIV/AIDS strategy laid out in the policy document 'Meeting the Challenge: Australia's International HIV/AIDS Strategy' (2004). This project directly addresses research priorities identified in the analytical report for the White Paper on Australia's AID program, 'HIV/AIDS in the Asia Pacific Region' (AusAID 2005): (1) the cultural, economic, and political dynamics driving the HIV epidemic in Asia; (2) the nexus between HIV/AIDS, economic activity, and development; and (3) the Asian experience of feminisation and gender impacts as factors in the epidemic HIV in the region.Read moreRead less
Reforming the Male: Masculinity, Medicalisation and Men's Health. Men's health is an issue of significant national importance and community concern. This project will contribute to knowledge of the social and cultural determinants of men's health and health practices in Australia. It is at the forefront of new approaches to men's health which emphasise the impact of norms and practices of masculinity on wellbeing. As well as providing specific insight into problems such as attention deficit di ....Reforming the Male: Masculinity, Medicalisation and Men's Health. Men's health is an issue of significant national importance and community concern. This project will contribute to knowledge of the social and cultural determinants of men's health and health practices in Australia. It is at the forefront of new approaches to men's health which emphasise the impact of norms and practices of masculinity on wellbeing. As well as providing specific insight into problems such as attention deficit disorder and depression in men, the project will also contribute to international debate about medicalisation, the rise of pharmacological treatments for problems of living and the existence of a crisis in masculinity.
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The rise of new cultural networks in Asia in the twenty-first century. Understanding Asia's dramatically changing cultural climate is fundamental to Australia's future cultural engagement with the region, consistent with the National Research Priority goal to 'understand our region and the world'. This project will document and improve understanding of new Asian art and art museum-related cultural networks, shedding light on their regional and global profiles and interactions. It will enhance un ....The rise of new cultural networks in Asia in the twenty-first century. Understanding Asia's dramatically changing cultural climate is fundamental to Australia's future cultural engagement with the region, consistent with the National Research Priority goal to 'understand our region and the world'. This project will document and improve understanding of new Asian art and art museum-related cultural networks, shedding light on their regional and global profiles and interactions. It will enhance understanding of Australia's role in creative industries and networks in Asia, providing a platform for future Australian policy and participation in these networks. Such knowledge will build Australia's research base on Asian art, museums and culture, and enhance Australia's collaborations and connectivity with Asia.Read moreRead less