Genetic and environmental causes of asthma are poorly understood. The WATCH for asthma project will study Western Australian (WA) families in which there was a twin or higher order multiple birth (twin families) in order to measure inherited and environmental contributions to the development of asthma. All WA twin families, whose infants were born during 1990 to 1995, will be invited to become part of an existing Healthway funded, population based registry of WA Twin Child Health (the WATCH stud ....Genetic and environmental causes of asthma are poorly understood. The WATCH for asthma project will study Western Australian (WA) families in which there was a twin or higher order multiple birth (twin families) in order to measure inherited and environmental contributions to the development of asthma. All WA twin families, whose infants were born during 1990 to 1995, will be invited to become part of an existing Healthway funded, population based registry of WA Twin Child Health (the WATCH study). The WATCH study has already invited 2,751 WA twin families to participate and is the only population based twin study in Australia. Funding of this study by NH and MRC will enable the extension of this unique registry to include more specific clinical information about those families in which one or more of the twins has asthma. In addition to questionnaire data, DNA and physiological information will be collected, including a potentially important new measure of airway inflammation, exhaled nitric oxide which has yet to be studied for familial aggregation. We will use the extended WATCH dataset to undertake a comprehensive investigation of the genetic epidemiology of childhood asthma. This work offers the potential to advance our current understanding of the causes of both childhood asthma and associated traits (e.g., 'twitchy' airways). By exploring the relationships between different components of asthma, we will generate information to assist us to design better epidemiological and genetic studies of asthma. At the time of recruitment, if consent is given, blood will also be taken for DNA extraction and frozen storage. This will generate a powerful data base that can later be used for to search at a molecular level for genes potentially important in causing childhood asthma. Finally, by extending the WATCH study database we will be enhancing a research resource that could potentially be used for future studies of common complex diseases other than asthma.Read moreRead less
I conduct epidemiological research on illicit drug use and harm, with a particular focus upon surveillance of drug use disorders and morbidity in sentinel populations. My epidemiological research has focused particularly on the comorbidity between drug de
Exploring Innovative Epidemiological Research To Understand Sexually Transmissible Infections In Large Cohorts
Funder
National Health and Medical Research Council
Funding Amount
$396,249.00
Summary
The aim of my postdoctoral research is to develop skills in epidemiological and sexual health research dealing with large cohorts, and to produce data that will aid in the improvement of sexual health outcomes in the population. One study I will work on is The National Survey of Sexual Attitudes and Lifestyles, a population-based survey of 15,000 men and women covering a range of sexual and reproductive health outcomes, and measuring the prevalence of sexually transmissible infections.
On The Scene: The Epidemiology Of HIV Among Men Who Have Sex With Men (MSM) In Victoria
Funder
National Health and Medical Research Council
Funding Amount
$73,397.00
Summary
This PhD will focus specifically on HIV among men who have sex with men in Victoria in effort to identify factors that may explain recent increases in rates of new HIV diagnoses and explore characteristics associated with HIV risk. It will incorporate surveillance and epidemiological data, examinations of local health promotion and HIV prevention initiatives and incorporate modelling methods for HIV to support HIV prevention programs and inform health and service planning in Australia.
Methodology For Population Health Research: Training And Innovation In Longitudinal Studies
Funder
National Health and Medical Research Council
Funding Amount
$1,963,750.00
Summary
This proposal builds on the applicants' experience with existing cohort studies to identify, evaluate and address areas of methodological concern, particularly with longitudinal studies. The group's ability to develop robust longitudinal methods in relation to these concerns will have the potential for both increasing knowledge of the determinants of population health and increasing their ability to attract trainee biostatisticians, an identified area of need in the country as a whole. The grant ....This proposal builds on the applicants' experience with existing cohort studies to identify, evaluate and address areas of methodological concern, particularly with longitudinal studies. The group's ability to develop robust longitudinal methods in relation to these concerns will have the potential for both increasing knowledge of the determinants of population health and increasing their ability to attract trainee biostatisticians, an identified area of need in the country as a whole. The grant will help position Australia at the cutting edge of research skills and methodology involved with longitudinal studies. Longitudinal studies provide a powerful means of collecting information about the health of populations. This grant will use multi-disciplinary approaches to develop innovative methods for designing longitudinal studies, collecting and analysing data and communicating results to improve people's health.Read moreRead less
Improving Research Evidence Quality Using Individual Patient Data, Prospective Meta-analysis And Trial Registration
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
The quality of evidence we use to make health care decisions can be improved if we use systematic reviews that are planned ahead, that use raw data from each participant and include all the trials that have looked at the clinical problem. This research program will utilise these three ways of obtaining better quality data and will thus make research results more reliable. In particular, we will use these techniques to address health problems in mothers and babies.
Translational Public Health Research Addressing Complex Questions In Maternal, Perinatal And Indigenous Health
Funder
National Health and Medical Research Council
Funding Amount
$420,872.00
Summary
The health of women during pregnancy and the first year after giving birth is critical to the health and well-being of children. This research aims to improve understanding of the causes and consequences of poor maternal health and contribute to better informed policy and practice in maternity, early postnatal and primary care services. It focuses on 3 major themes: improving women’s health after childbirth; maternity and early postnatal care; and Indigenous women’s and children’s health.
ENDOPHTHALMITIS IN WESTERN AUSTRALIA (1980-2002): INCIDENCE, MANAGEMENT AND EFFECTIVENESS OF CHEMOPROPHYLAXIS
Funder
National Health and Medical Research Council
Funding Amount
$348,942.00
Summary
Endophthalmitis is a serious sight threatening infection of the internal cavities of the eye. Although endophthalmitis is not a common post-operative complication of eye surgery, 200 cases of this serious sight threatening infection occur each year in Australia following cataract surgery. Not only is this condition extremely distressing to the patients and surgeons alike, around A$4 million per year is spent each year treating the infection. Also, there is significant expenditure on methods to p ....Endophthalmitis is a serious sight threatening infection of the internal cavities of the eye. Although endophthalmitis is not a common post-operative complication of eye surgery, 200 cases of this serious sight threatening infection occur each year in Australia following cataract surgery. Not only is this condition extremely distressing to the patients and surgeons alike, around A$4 million per year is spent each year treating the infection. Also, there is significant expenditure on methods to prevent the infection that have not, as yet, been demonstrated beneficial. Our study will use a multidisciplinary team consisting of consultant ophthalmologists, public health researchers, a biostatistician and health economist to assess the impact of endophthalmitis in WA from 1980-2002 (around 480 cases). The population-based WA Linked Database provides a unique opportunity to produce what will be the largest population study of endophthalmitis. Data from the study will provide important information to develop best-practice treatment guidelines to prevent endophthalmitis following cataract surgery. The significance of this study will be that accurate information on the clinical epidemiology and true cost of endophthalmitis will be obtained for WA. By studying the records of patients with endophthalmitis and comparing them with matched patients, who did not have post-operative endophthalmitis following cataract surgery, we will characterise the risks for this severe complication by identifying the underlying factors that are responsible for the infection. We will also better understand the effect of methods used to prevent the infection. The use of a whole population-based study to assess methods of endophthalmitis prevention has not been done before and will have a significant beneficial impact on health policy and best-practice, not only in Australia, but also internationally.Read moreRead less