Probiotic Prawn Oral Immunotherapy (ProPIT) For Treatment Of Prawn Allergy
Funder
National Health and Medical Research Council
Funding Amount
$1,865,369.00
Summary
A ‘curative’ food allergy treatment is needed to prevent deaths and improve care. We recently showed that probiotic peanut oral immunotherapy (PPOIT) was highly effective for treating peanut allergy. 82% of PPOIT treated children gained tolerance compared to 4% of the placebo group. We will now test the combined probiotic-food OIT approach for treating prawn allergy. If successful, we will have identified the first treatment for prawn allergy and a platform treatment for other food allergies.
Early Career Industry Fellowships - Grant ID: IE230100437
Funder
Australian Research Council
Funding Amount
$417,237.00
Summary
Nanobubbles for effective and energy efficient water treatment. This project aims to produce new knowledge for developing ozone nanobubbles as a technological option for the water industry where commercially suitable technologies are unavailable. Australian water utilities have identified two key challenges: destruction of micropollutants and natural organic matter in recycled and reservoir water, respectively. New knowledge from the project will allow these water utilities to utilise the extrao ....Nanobubbles for effective and energy efficient water treatment. This project aims to produce new knowledge for developing ozone nanobubbles as a technological option for the water industry where commercially suitable technologies are unavailable. Australian water utilities have identified two key challenges: destruction of micropollutants and natural organic matter in recycled and reservoir water, respectively. New knowledge from the project will allow these water utilities to utilise the extraordinary properties of nanobubbles and the strong oxidation capability of ozone for effective and energy efficient water treatment. Tech-transfer to the industry is guaranteed through a scientifically designed pilot plant for benchmarking against the current state of the art ozonation process and reverse osmosis.Read moreRead less
Uptake, Sustainability And Impact Of Scaling Up Point-of-care Testing For Sexually Transmissible Infections In Remote And Regional Aboriginal Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,461,788.00
Summary
Aboriginal youth experience unacceptably high rates of curable sexually transmissible infections (STI). Coverage of testing and treatment is insufficient for disease control but could be enhanced via point-of-care (POC) testing. We have been trialling a highly accurate STI/POC diagnostic in the TTANGO (Test, Treat ANd GO) trial. The TTANGO2 partnership will assess the long-term uptake, sustainability and impact of POC testing in 20 Aboriginal health services in regional/remote WA over 5 years.
Pathophysiology And Alternative Preventative Strategy For Breast Cancer Chemotherapy-induced Bone Loss
Funder
National Health and Medical Research Council
Funding Amount
$540,356.00
Summary
Combination cytotoxic chemotherapy is the current optimal approach for treating breast cancer in premenopausal women. However, long-term skeletal defects (osteoporosis and fractures) caused by the chemotherapy have become an increasingly serious problem due to its intensified use and improved patient survival rate. This project seeks to elucidate the mechanisms for chemotherapy-induced bone defects and to initiate development of a preventative treatment using natural bioactive micronutrients.
Early stress experiences and stress resilience in pigs. Animal stress has substantial implications on animal productivity, health and welfare of farm animals and thus farm profitability. This project aims to examine the stress resilience in pigs. Modern pig farming is a major source of food, providing substantial nutritional, social and economic benefits in Australia and worldwide. Animal welfare is of increasing concern to the public, consumers and pork producers, and stress vulnerability is an ....Early stress experiences and stress resilience in pigs. Animal stress has substantial implications on animal productivity, health and welfare of farm animals and thus farm profitability. This project aims to examine the stress resilience in pigs. Modern pig farming is a major source of food, providing substantial nutritional, social and economic benefits in Australia and worldwide. Animal welfare is of increasing concern to the public, consumers and pork producers, and stress vulnerability is an animal health and production problem in the life of the commercial pig. This project will generate new knowledge on early life management to endow stress resilience in pigs, with expected benefits for animal welfare, farm productivity and profitability.Read moreRead less
Preclinical Evaluation Of The Novel Therapeutic Compound APP96-110 In An Ovine Model Of Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$874,734.00
Summary
Traumatic brain injury (TBI) is a significant cause of death and disability, and yet there are currently no effective treatments to improve outcome following such an insult. Our laboratory has developed a novel therapeutic compound, by identifying an endogenous neuroprotective molecule, in the amyloid precursor protein and then identifying the active site and modifying it to improve its efficacy. We will be testing this compound in our sheep model of TBI.
Ultrasound for control of cyanobacteria. Blue-green algae, also known as cyanobacteria, forms in drinking water supplies in Australia and can cause water-quality problems. Current methods to treat blue-green algae involve the use of Copper Sulphate, which is not an environmentally friendly compound. A potential alternative environmentally friendly water-treatment method involves the use of ultrasound to disrupt the cyanobacteria. The aim of this project is to determine the physical properties of ....Ultrasound for control of cyanobacteria. Blue-green algae, also known as cyanobacteria, forms in drinking water supplies in Australia and can cause water-quality problems. Current methods to treat blue-green algae involve the use of Copper Sulphate, which is not an environmentally friendly compound. A potential alternative environmentally friendly water-treatment method involves the use of ultrasound to disrupt the cyanobacteria. The aim of this project is to determine the physical properties of the cyanobacteria when excited with ultrasound for the purpose of finding an efficient method to treat large volumes of water. Read moreRead less
Sustainable Hydrogen Production from Used Water. The project aims to address the pressing challenge of water scarcity in hydrogen production by developing an innovative approach of using used water as the feed for water electrolysis. The project will result in an in-depth understanding of the impacts of water impurities in used water on the performance and durability of water electrolysers, and develop guidelines for the design of highly durable water electrolysers and the operation and upgrade ....Sustainable Hydrogen Production from Used Water. The project aims to address the pressing challenge of water scarcity in hydrogen production by developing an innovative approach of using used water as the feed for water electrolysis. The project will result in an in-depth understanding of the impacts of water impurities in used water on the performance and durability of water electrolysers, and develop guidelines for the design of highly durable water electrolysers and the operation and upgrade of existing wastewater treatment plants. The project will advance the practical applications of water electrolysis for scalable and sustainable hydrogen production and help Australia secure a leading position in the global emerging hydrogen economy.Read moreRead less
Randomised Control Trial Of Effectiveness Of Silver Fluoride In Managing Deciduous Dental Caries In Remote Aboriginal Communities
Funder
National Health and Medical Research Council
Funding Amount
$695,220.00
Summary
This study seeks to test a non-invasive treatment for dental decay in young children which may prevent the progression of the decay further into the tooth. This treatment is currently used in some areas. Dental decay is very common in young children in remote communities where access to dental care is often limited. The treatment may reduce pain and oral and facial infections sometimes leading to hospitalisation.
Improving anti-salt crystallisation for solar-steam desalination. This project aims to solve a critical issue of solar-steam desalination by fundamental research. The solar-steam desalination technology offers an ideal strategy to utilize solar light as the energy source for desalination and water purification to produce affordable clean water. Photothermal materials play a key role in the desalination system to convert sunlight to heat and subsequently evaporate the saline water to generate ste ....Improving anti-salt crystallisation for solar-steam desalination. This project aims to solve a critical issue of solar-steam desalination by fundamental research. The solar-steam desalination technology offers an ideal strategy to utilize solar light as the energy source for desalination and water purification to produce affordable clean water. Photothermal materials play a key role in the desalination system to convert sunlight to heat and subsequently evaporate the saline water to generate steam as clean water. However, salt crystallization on the photothermal material surfaces severely limits the performance of the materials and clean water production. Solving this problem could accelerate the commercialisation and application of this technology, which will benefit millions of people worldwide.Read moreRead less