Multiple Antibiotic Resistance In An Acinetobacter Baumannii Global Clone
Funder
National Health and Medical Research Council
Funding Amount
$606,580.00
Summary
Antibiotic resistant bacteria that cause infections in hospitals can originate anywhere, then spread world wide. They start off resistant to a few antibiotics, then become resistant to new antibiotics that are introduced to treat them. This project will investigate how resistance to antibiotics was acquired by Acinetobacter baumannii which is now resistant to most antibiotics, and why the old resistance genes are not being lost. This will help track these bacteria moving into and around Australi ....Antibiotic resistant bacteria that cause infections in hospitals can originate anywhere, then spread world wide. They start off resistant to a few antibiotics, then become resistant to new antibiotics that are introduced to treat them. This project will investigate how resistance to antibiotics was acquired by Acinetobacter baumannii which is now resistant to most antibiotics, and why the old resistance genes are not being lost. This will help track these bacteria moving into and around Australia.Read moreRead less
A New Mechanism For Transposition Of Antibiotic Resistance Genes
Funder
National Health and Medical Research Council
Funding Amount
$501,839.00
Summary
Understanding how antibiotic resistance genes are acquired by bacteria is important if we are to understand how bacteria become resistant in so many antibiotics, limiting treatment options. This project will investigate the way a family of insertion sequences captures and then moves resistance genes. This mechanism contributes to resistance in many bacterial pathogens including ones that are resistant to many different antibiotics.
How Insertion Sequences Mobilize Antibiotic Resistance Genes
Funder
National Health and Medical Research Council
Funding Amount
$675,086.00
Summary
Resistance to all antibiotics available for treatment of bacterial infections is a cause for global concern (Word Health Organization, US Centres for Disease Control) as it also compromises therapies relying on antibiotics such as transplantation and cancer chemotherapy. This project will seek to understand how resistance genes are recruited and disseminated into different types of bacteria that repeatedly spread around the world.
Role Of IS26 In Antibiotic Resistance Gene Recruitment, Dissemination And Expression
Funder
National Health and Medical Research Council
Funding Amount
$457,879.00
Summary
Antibiotic resistance is increasing, compromising the efficacy of front-line antibiotics. Untreatable infections due to bacteria that are resistant to all available antibiotics are being seen more often. To control the spread of resistance, an understanding of how resistance arises and is spread among bacteria is needed. This requires information about how the genetic elements that mobilize them work. This project will study one of the most important of these elements.