Circulating Tumour DNA To Monitor Treatment Response And Resistance In Chronic Lymphocytic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$876,950.00
Summary
Many cancers shed small amounts of DNA (ctDNA) into the patient’s bloodstream and recent advances in genomic technologies now allow levels of ctDNA to be accurately measured in the blood. Changes in ctDNA levels have potential to be used as specific markers of disease progression and/or response to cancer therapy. This project will evaluate if ctDNA can be used to monitor treatment responses and individualise treatment decisions in patients with chronic lymphocytic leukaemia.
Centre For Research Excellence In Implementation Science In Oncology (CRE-ISO)
Funder
National Health and Medical Research Council
Funding Amount
$2,495,783.00
Summary
One of the key issues in delivering care to cancer patients is to ensure that the treatment provided is evidence-based. We need a concerted effort and training for the next generation of researchers and clinicians to translate what we know into improved practices. This Centre for Research Excellence harnesses new ideas in implementation science to make improvements. Researchers will work side-by-side with clinicians, policymakers, and patients in achieving higher levels of evidence-based care.
Scalability Of The Transform-Us! Program To Promote Children's Physical Activity And Reduce Prolonged Sitting In Victorian Primary Schools
Funder
National Health and Medical Research Council
Funding Amount
$549,823.00
Summary
Transform-Us! is an innovative primary school program that has been found to substantially increase children’s physical activity levels, reduce sitting time and benefit health. With simple changes to the school and classroom environments and teaching practices (eg, standing lessons) we will work with partners in the education and health systems to translate this program across Victorian primary schools to determine the real-world implementation and impact of this program over 5 years.
Therapeutic Targeting Of Cell Cycle Checkpoint Aberrations In Pancreatic Cancer: Personalised Medicine In Action
Funder
National Health and Medical Research Council
Funding Amount
$634,354.00
Summary
Less than 5% of people with pancreatic cancer (PC) survive 5 years, and the odds of patients beating this disease have remained unchanged for 50 years. Consequently, there is an urgent need to develop novel treatment approaches for this highly aggressive cancer. Our study aims to define novel therapeutic strategies for PC utilising specific anti-proliferative therapies and a personalised “companion biomarker” directed strategy.
Improving Linkages For Chronic Disease Prevention In Indigenous Communities: A Quality Improvement Approach.
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Primary health care and public health are often conceived as two entities providing complementary services within the health system. This research aims to better understand how to link these complementary services by using quality improvement methods and to identify successful interventions that facilitate these linkages in the prevention of chronic disease in Indigenous communities.
Training Health Professionals In Tobacco Cessation And Evidence Translation For Aboriginal Australians
Funder
National Health and Medical Research Council
Funding Amount
$832,723.00
Summary
Our published pilot investigations have shown that smoking cessation programs among Aboriginal and/or Torres Strait Islander Australians are profoundly lacking, with current tobacco prevalence estimates still at 45%. Through a cluster randomised delayed intervention controlled trial design, our proposal includes a opportunistic approach to training existing health professionals in tobacco cessation with a number of methods to reduce tobacco prevalence amongst Indigenous Australians.
Individualising Care For Patients With Chronic Hepatitis C: Predicting Side Effects And Treatment Response Using Genomic And Proteomic Approaches.
Funder
National Health and Medical Research Council
Funding Amount
$55,575.00
Summary
Patients undergoing treatment for hepatitis C must endure a treatment characterized by unpredictable treatment side effects and uncertainty about the likelihood of cure. This project will investigate genetic predictors of treatment related side-effects and protein markers to predict treatment response. Better definition of the risks and benefits of therapy, may facilitate patients and clinicians to make more informed decisions about treatment, thus individualising treatment and potentially impro ....Patients undergoing treatment for hepatitis C must endure a treatment characterized by unpredictable treatment side effects and uncertainty about the likelihood of cure. This project will investigate genetic predictors of treatment related side-effects and protein markers to predict treatment response. Better definition of the risks and benefits of therapy, may facilitate patients and clinicians to make more informed decisions about treatment, thus individualising treatment and potentially improving the safety and efficacy of therapy.Read moreRead less
Best Evidence To Best Practice: Implementing An Innovative Model Of Care For Nutritional Management Of Patients With Head And Neck Cancer
Funder
National Health and Medical Research Council
Funding Amount
$276,250.00
Summary
This project aims to implement and evaluate an innovative best-practice dietetic model of care (MOC) based on published Evidence Based Guidelines for Nutritional Management of Patients with Head and Neck Cancer. Through integration with the multidisciplinary team, the MOC will take a patient-centred approach to delivery of nutritional care to minimise the detrimental sequelae of malnutrition and improve outcomes in this complex patient group.
Optimising Early Interventions For Young People With Emerging Mood Disorder
Funder
National Health and Medical Research Council
Funding Amount
$2,653,052.00
Summary
One of our greatest health challenges is to develop highly-personalised interventions for teenagers and young adults with emerging mood disorders, like major depression or bipolar disorder. This new Australian centre combines our national expertise and links it with research innovation and training in key European and North American centres. It tests the viability of selecting the best treatments for young people with mood disorders on the basis of novel genetic, neuropsychological, circadian, i ....One of our greatest health challenges is to develop highly-personalised interventions for teenagers and young adults with emerging mood disorders, like major depression or bipolar disorder. This new Australian centre combines our national expertise and links it with research innovation and training in key European and North American centres. It tests the viability of selecting the best treatments for young people with mood disorders on the basis of novel genetic, neuropsychological, circadian, imaging, immunological or clinical methods.Read moreRead less
An International Clinical Trial To Evaluate New Therapies To Improve Survival Of Children With Relapsed Acute Lymphoblastic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$1,567,500.00
Summary
Children who relapse with childhood leukaemia have only a 50% chance of being alive after 5 years. We will participate in a new international trial involving most European and all Australian and New Zealand childhood oncology centres, to test the effectiveness of promising new treatments and to perform biological studies which should enable doctors in future to pick the best treatment for each of these patients.