Nocturnin: A Post-transcriptional Regulator Of Circadian Fat Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$574,696.00
Summary
Our metabolism is aligned with the 24-hour rotation of the earth in what is termed the circadian clock. Being misaligned to this clock explains jetlag and the poor health associated with shift-workers. For example, whether fat is utilised or stored depends on the time of day. This study aims to investigate the post-transcriptional mechanisms that underpin the rhythmic changes that occur throughout our bodies to ensure that our metabolism is matched to our environment.
UNDERSTANDING THE MOLECULAR MECHANISMS CONTROLLING NUCLEOLAR SURVEILLANCE IN DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$855,972.00
Summary
Alterations in the ability of cells to make ribosomes, the cellular factories that make protein, contribute to a range of diseases including cancer and a class of inherited disorders called ribosomopathies that are rare but largely untreatable. These changes cause disease by controlling the “nucleolar surveillance pathway” that causes cells to either stop dividing or die. Here we propose to identify new genes that regulate this pathway to identify new targets for treating these diseases.
The 3’ UTR Codes That Control MRNA Translation In Development
Funder
National Health and Medical Research Council
Funding Amount
$609,281.00
Summary
We are the product of an exquisite programme that controls when and where genes are turned on and off, over time, from a single cell to adulthood. This project concerns codes that regulate this programme with a focus on early development, the germline and neuronal cells. Using the same technology that now allows individuals to sequence their own genome, we will study an aspect of this timing in model organisms having genetic lesions in specific pathways that relate also to human health and disea ....We are the product of an exquisite programme that controls when and where genes are turned on and off, over time, from a single cell to adulthood. This project concerns codes that regulate this programme with a focus on early development, the germline and neuronal cells. Using the same technology that now allows individuals to sequence their own genome, we will study an aspect of this timing in model organisms having genetic lesions in specific pathways that relate also to human health and disease.Read moreRead less
Reducing The Greatest Uncertainty In Radiotherapy.
Funder
National Health and Medical Research Council
Funding Amount
$594,197.00
Summary
The weakest link in radiotherapy is defining treatment volumes (contouring). Lack of accuracy and consistency in clinical trial contouring has been shown to result in reduced patient outcomes. Manual review of contouring is resource intensive, expensive and for advanced treatments unachievable in a timely fashion. We will assess an automated approach to contouring assessment using 4 clinical trial datasets, changing practice for future studies and enabling consistent assessment in the clinic.