Enhancing fertility for the Thoroughbred and Standardbred industries. Enhancing fertility for the Thoroughbred and Standardbred industries. Responding to industry calls for improved methods of detecting and managing infertility in both stallions and mares, this project aims to provide a platform for competitive collaborations between universities, biotechnology companies and horse breeders: the end-users of technological developments in equine reproduction. The Thoroughbred and Standardbred bree ....Enhancing fertility for the Thoroughbred and Standardbred industries. Enhancing fertility for the Thoroughbred and Standardbred industries. Responding to industry calls for improved methods of detecting and managing infertility in both stallions and mares, this project aims to provide a platform for competitive collaborations between universities, biotechnology companies and horse breeders: the end-users of technological developments in equine reproduction. The Thoroughbred and Standardbred breeding industries contribute over $6.5 billion per annum to the Australian economy and employ thousands of staff across their value chains. However, these industries suffer from breeding program inefficiencies that amount to over $800 million in annual losses. Expected outcomes are novel reproductive technologies and specialised research capabilities that will make the Australian equine industry a global leader.Read moreRead less
Frontotemporal Dementia And Motor Neurodegenerative Syndromes
Funder
National Health and Medical Research Council
Funding Amount
$11,583,107.00
Summary
Frontotemporal degeneration of the brain is a leading cause of morbidity. It is a pathologically heterogeneous group of rapidly-progressive disorders with behavioural, language and motor deficits. This research program brings together international leaders in clinical, pathological and biological research of these syndromes, aiming to fast track new knowledge and innovations to develop the necessary tools and therapies to effectively diagnose, manage and treat these disorders.
Enhancing the efficiency of equine reproduction: relevant to the Thoroughbred and Standardbred breeding industries. The purpose of this project is to link the equine breeding industry with a major centre of reproductive research at the University of Newcastle. By creating this unique nexus, major efficiency gains will be achieved for this industry that will not only secure its international competitiveness but also significantly enhance its profitability.
Discovery Early Career Researcher Award - Grant ID: DE180100894
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Molecular mechanisms of equine fertility and early recognition of pregnancy. This project aims to identify biomarkers of stallion fertility and early pregnancy in thoroughbred and Standardbred horses using biochemistry, proteomics and ribonucleic acid analyses. Responding to industry calls for improved methods of detecting and managing infertility in both stallions and mares, this project will connect Australian horse breeders and international clinical experts with the world renowned reproducti ....Molecular mechanisms of equine fertility and early recognition of pregnancy. This project aims to identify biomarkers of stallion fertility and early pregnancy in thoroughbred and Standardbred horses using biochemistry, proteomics and ribonucleic acid analyses. Responding to industry calls for improved methods of detecting and managing infertility in both stallions and mares, this project will connect Australian horse breeders and international clinical experts with the world renowned reproductive Priority Research Centre with the intended outcome of novel reproductive technologies and diagnostic tests. This should both secure international competitiveness and significantly enhance profitability and employment in this culturally significant industry.Read moreRead less
Does developmental noise have an epigenetic basis? One's ultimate phenotype is the result of a combination of genotype and environment, and includes a poorly understood component termed ?developmental noise?. The molecular basis of developmental noise remains unknown, but it appears to be established in early development and to be retained for the life of the organism. We propose that the molecular basis of developmental noise is the epigenetic state of the genome. The stochastic nature of th ....Does developmental noise have an epigenetic basis? One's ultimate phenotype is the result of a combination of genotype and environment, and includes a poorly understood component termed ?developmental noise?. The molecular basis of developmental noise remains unknown, but it appears to be established in early development and to be retained for the life of the organism. We propose that the molecular basis of developmental noise is the epigenetic state of the genome. The stochastic nature of the establishment of epigenetic state, combined with its heritability during mitosis, provides all the essential components for developmental noise. If our hypothesis proves correct, our work will have a major impact on the understanding of one of the most basic concepts in genetics.Read moreRead less
Trade-offs underlying the evolution of female mating strategies. Multiple mating by females (polyandry) is a fundamental problem in behavioural ecology. The project will utilise an Australian species of stingless bee to quantify both the costs and the most probable benefits of polyandry. This will provide insight into the trade-offs underlying the evolution of mating strategies in this species and in general. Stingless bees are important members of many Australian ecosystems and have consider ....Trade-offs underlying the evolution of female mating strategies. Multiple mating by females (polyandry) is a fundamental problem in behavioural ecology. The project will utilise an Australian species of stingless bee to quantify both the costs and the most probable benefits of polyandry. This will provide insight into the trade-offs underlying the evolution of mating strategies in this species and in general. Stingless bees are important members of many Australian ecosystems and have considerable economic potential as well. The knowledge gained during the project will also substantially aid the development and management of the commercial use of stingless bees, which will have both ecological and economic benefits to Australia.Read moreRead less