Transgenic Expression Of The EWS-WT1 Fusion Protein,inducing The Development Of Tumour That Replicates The Human Disease
Funder
National Health and Medical Research Council
Funding Amount
$112,976.00
Summary
A genetic translocation encoding the EWS-WT1 fusion protein is found desmoplastic small round cell tumours. Our aim is to examine the effect of this protein in inducing tumour growth in tissue cell lines. A virus will then be used to introduce the genetic translocation into mice to examine the effect of this protein on tumour growth in a mammal, thereby serving as a 'solid tumour model' to try and identify therapeutic targets.
Molecular Mechanisms In The Regulation Of Allergy And Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$4,977,215.00
Summary
To understand the fundamental cellular and molecular processes that underpin the development of allergic disorders, viral infections of the respiratory tract and chronic inflammatory diseases of the lung. There is particular interest in the role of immune cells, such T cells and granulocytes in these disorders, and in the processes that control their function. Understanding these processes will provide new insights into the immune system's role in health and disease, and help develop better ther ....To understand the fundamental cellular and molecular processes that underpin the development of allergic disorders, viral infections of the respiratory tract and chronic inflammatory diseases of the lung. There is particular interest in the role of immune cells, such T cells and granulocytes in these disorders, and in the processes that control their function. Understanding these processes will provide new insights into the immune system's role in health and disease, and help develop better therapies to treat inflammatory disorders.Read moreRead less
The cross-disciplinary team performing this research will examine how mobile DNA elements found in brain cells move in response to learning and memory exercises in mice, and whether these changes generate an address system for parts of the brain to be turned on by specific experiences. This work has major implications for our fundamental understanding of how the brain works in healthy individuals, as well as people affected by neurodevelopmental and neurodegenerative conditions.