Molecular Diagnosis And Therapy Of Autoimmune Disease Using Translational And Reverse Translational Approaches
Funder
National Health and Medical Research Council
Funding Amount
$2,331,372.00
Summary
We plan to translate our recent discoveries on human gene variants and molecules produced by immune cells (follicular T cells) into effective therapies for autoimmune diseases. This will involve understanding the mechanisms by which the genes and molecules regulate immune tolerance, stratifying patients with autoimmune disease using newly identified biomarkers, trialling existing biologicals according to affected molecular pathway, and taking novel targets through to commercialisation.
Fabrication of silicon solar cells in a Lunar-like vacuum environment. In-situ power generation on the Moon is essential for the advancement of space exploration and habitation. At present this involves transportation of solar cells to the Moon. This proposal aims to pave the way for manufacture of solar cells on the Moon from Lunar materials. Utilising the future extraction and purification of silicon, abundant in lunar regolith, the project will focus on fabrication of silicon solar cells. Thi ....Fabrication of silicon solar cells in a Lunar-like vacuum environment. In-situ power generation on the Moon is essential for the advancement of space exploration and habitation. At present this involves transportation of solar cells to the Moon. This proposal aims to pave the way for manufacture of solar cells on the Moon from Lunar materials. Utilising the future extraction and purification of silicon, abundant in lunar regolith, the project will focus on fabrication of silicon solar cells. This will provide power for: water mining, oxygen extraction, vehicles and habitats on the Moon and delivery of materials to Low Earth Orbit. The proposed research aims to develop solar cells that can be manufactured on the Moon, using materials abundant there, and techniques exploiting the natural vacuum of space.Read moreRead less
Engineering stable, efficient perovskite solar cells. This project aims to address and resolve a critical issue facing perovskite solar cells which have enormous potential as a future technology for the large-scale generation of cheap, clean electricity: their instability under actual operating conditions. The project is expected to make significant fundamental advances in compositional, structural and interface engineering. This project will benefit the environment by paving the way for the wi ....Engineering stable, efficient perovskite solar cells. This project aims to address and resolve a critical issue facing perovskite solar cells which have enormous potential as a future technology for the large-scale generation of cheap, clean electricity: their instability under actual operating conditions. The project is expected to make significant fundamental advances in compositional, structural and interface engineering. This project will benefit the environment by paving the way for the widespread adoption of cheaper and more efficient solar cells.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100812
Funder
Australian Research Council
Funding Amount
$425,888.00
Summary
Is degradation of photovoltaic modules predictable and preventable? This project aims to determine the fundamental properties of the hydrogen related defect causing degradation of commercial solar modules and develop models to predict its impact. The defect causes up to 16% power loss and is likely to affect all photovoltaics due to the universal behaviour of hydrogen in semiconductors. Through new techniques combining deuterium (heavy hydrogen) and machine learning, the key project outcomes are ....Is degradation of photovoltaic modules predictable and preventable? This project aims to determine the fundamental properties of the hydrogen related defect causing degradation of commercial solar modules and develop models to predict its impact. The defect causes up to 16% power loss and is likely to affect all photovoltaics due to the universal behaviour of hydrogen in semiconductors. Through new techniques combining deuterium (heavy hydrogen) and machine learning, the key project outcomes are new knowledge of hydrogen behaviour, mitigation of degradation and predictive models to test and forecast the future output of affected modules. This is critical for system design and reliability, manufacturer warranty terms, investor returns, consumer confidence, and ultimately mitigating the climate crisis.Read moreRead less
Degradation of atomically dispersed M-N-C carbon catalysts in acidic media. This project aims to provide a clear understanding of the degradation mechanisms of transition metal (M) and nitrogen (N) co-doped carbon (M-N-C) catalysts in acidic media by utilising new model catalysts, standardised degradation tests, comprehensive catalyst characterisation, and machine learning tools to interrogate mechanistic hypotheses and link degradation mechanisms to specific catalyst characteristics. This proje ....Degradation of atomically dispersed M-N-C carbon catalysts in acidic media. This project aims to provide a clear understanding of the degradation mechanisms of transition metal (M) and nitrogen (N) co-doped carbon (M-N-C) catalysts in acidic media by utilising new model catalysts, standardised degradation tests, comprehensive catalyst characterisation, and machine learning tools to interrogate mechanistic hypotheses and link degradation mechanisms to specific catalyst characteristics. This project expects to generate new knowledge on rationally designing robust hydrogen fuel cell catalysts. This will provide significant benefits, such as new knowledge on catalyst degradation, new catalysts for energy conversion applications, and collaborations with the industry to accelerate Australia’s shift to renewable energy.Read moreRead less
High Performance Anode for Direct Ammonia Solid Oxide Fuel Cells. Solid oxygen fuel cells are a clean energy generation device with very high energy efficiency and if with hydrogen as fuel, the emission is zero. However, the utilisation of hydrogen is limited by on-board storage. Ammonia is a promising hydrogen carrier and can be directly fed to solid oxide fuel cells without fuel storage problem, and the products are just hydrogen and nitrogen. For direct ammonia solid oxide fuel cells, the key ....High Performance Anode for Direct Ammonia Solid Oxide Fuel Cells. Solid oxygen fuel cells are a clean energy generation device with very high energy efficiency and if with hydrogen as fuel, the emission is zero. However, the utilisation of hydrogen is limited by on-board storage. Ammonia is a promising hydrogen carrier and can be directly fed to solid oxide fuel cells without fuel storage problem, and the products are just hydrogen and nitrogen. For direct ammonia solid oxide fuel cells, the key challenge is the anode. This project aims to develop a high performance anode for direct ammonia solid oxide fuel cells with both high activity and high stability at low temperature (below 600 degree C), thus addressing a key issue to make the direct ammonia solid oxide fuel cells commercially viable.Read moreRead less
Composites for thermal expansion matched oxygen electrodes. This project aims to develop high performance composite oxygen electrodes by using both negative thermal expansion materials and electrolyte materials to tailor the thermal expansion and activities of the perovskite-based electrodes for use in reduced temperature solid oxide cells. Such composite electrodes will show highly matched thermal expansion with electrolyte without sacrificing high activity at reduced temperatures. This project ....Composites for thermal expansion matched oxygen electrodes. This project aims to develop high performance composite oxygen electrodes by using both negative thermal expansion materials and electrolyte materials to tailor the thermal expansion and activities of the perovskite-based electrodes for use in reduced temperature solid oxide cells. Such composite electrodes will show highly matched thermal expansion with electrolyte without sacrificing high activity at reduced temperatures. This project seeks to address an important practical issue in the operation of solid oxide power cells - thermal expansion compatibility, which causes poor efficiency outside a narrow temperature band.Read moreRead less
Characterising and Manipulating Triplet Interactions. Organic optoelectronic devices are based on organic semiconductors and are found throughout modern life. They underpin technologies such as phone and television displays, low-energy lighting, and solar cells.
The project Aims to use spectroscopy to comprehensively understand the underlying physics of organic optoelectronic device materials. This is Significant enabling science that will accelerate development of light-emitting diodes, solar ....Characterising and Manipulating Triplet Interactions. Organic optoelectronic devices are based on organic semiconductors and are found throughout modern life. They underpin technologies such as phone and television displays, low-energy lighting, and solar cells.
The project Aims to use spectroscopy to comprehensively understand the underlying physics of organic optoelectronic device materials. This is Significant enabling science that will accelerate development of light-emitting diodes, solar cells, and new quantum information technologies. Expected outcomes include new knowledge about organic semiconductors, enhanced Australian research capacity, and international collaboration. Benefits include device innovations and the training of researchers in synthesis, fabrication, and spectroscopy.Read moreRead less
Perovskite-silicon tandem solar cells: a pathway to 30 per cent efficiency. This project aims to develop a new type of solar cell that is much more efficient than today’s commercial silicon solar cells. Increasing cell efficiency is one of the most effective ways to reduce the cost of solar electricity, but silicon cells are approaching practical and theoretical limits. This project expects to boost the efficiency of silicon solar cells by adding a low-cost solar cell on top to create a tandem d ....Perovskite-silicon tandem solar cells: a pathway to 30 per cent efficiency. This project aims to develop a new type of solar cell that is much more efficient than today’s commercial silicon solar cells. Increasing cell efficiency is one of the most effective ways to reduce the cost of solar electricity, but silicon cells are approaching practical and theoretical limits. This project expects to boost the efficiency of silicon solar cells by adding a low-cost solar cell on top to create a tandem device. The expected outcome is a solar cell that can convert more than 30 per cent of incident sunlight into electricity, compared to 20-25 per cent for current cells. Developing cheap, high efficiency solar cells should further reduce the cost of solar electricity, and accelerate the uptake of clean energy.Read moreRead less