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Investigation Of The Roles Of Foxn1, Wnts And Autophagy In The Development And Function Of Thymic Epithelial Cells.
Funder
National Health and Medical Research Council
Funding Amount
$220,222.00
Summary
The immune system usually protects the body from infections. Occasionally, the immune system mistakenly recognises components of the body as foreign and attacks them, resulting in autoimmune diseases such as diabetes, multiple sclerosis and arthritis. An organ called the thymus is responsible for educating the immune system, and preventing autoimmune diseases. The proposed project will explore how the thymus develops, and how it teaches the immune system to ignore normal components of the body.
The Influence Of Glucocorticoid Hormones In T Cell Development And Function
Funder
National Health and Medical Research Council
Funding Amount
$406,980.00
Summary
The defence of the body to disease is a very complex process involving multiple interactions between subsets of white cells, in particular lymphocytes. This immune system, however, does not act in isolation but is subject to constant regulation by a variety of other cells and soluble factors. Particularly important in this regard is the impact of glucocorticoids which are normally associated with stress conditions. These steroids have been proposed to act at several levels in the immune system, ....The defence of the body to disease is a very complex process involving multiple interactions between subsets of white cells, in particular lymphocytes. This immune system, however, does not act in isolation but is subject to constant regulation by a variety of other cells and soluble factors. Particularly important in this regard is the impact of glucocorticoids which are normally associated with stress conditions. These steroids have been proposed to act at several levels in the immune system, usually causing suppression but they can also modify in a positive sense. Defining the targets of glucocorticoids and their precise functional impact will thus have very important implications for not only understanding the regulation of the immune response but also in the clinic. This project will make use of mice which have had the receptor for glucocorticoids genetically deleted. Focussing on T cells (the most important cells of the immune system) these mice will be examined in detail for alterations in the development of T lymphocytes and their function in defending the body against virus and tumours and their involvement in self destruction (autoimmune) diseases including multiple sclerosis.Read moreRead less
The Molecular Determinants Of Immunological Tolerance
Funder
National Health and Medical Research Council
Funding Amount
$473,477.00
Summary
Autoimmune diseases, such as type I diabetes and multiple sclerosis, are debilitating disorders that impose a massive toll on wellbeing in Australia and worldwide. This fellowship will support research aimed at determining the genes and mechanisms that control autoimmunity. New technologies will be brought to bear to track immune cells throughout their development, maturity and malfunction in disease settings. We aim to uncover new therapeutic targets to prevent and reverse autoimmune disease.
This project will investigate the factors that regulate the development and maintenance of a recently identified population of white blood cells called MAIT cells. MAIT cells are abundant in humans yet poorly understood. A better understanding of how these cells are regulated, and how they can be targeted in diseases, is necessary if we want to ultimately use these cells for immunotherapy.