To Determine The Role And Mechanism Of Action Of Tissue-type Plasminogen Activator In The Central Nervous System
Funder
National Health and Medical Research Council
Funding Amount
$504,097.00
Summary
Tissue-type plasminogen activator (t-PA) is used clinically to remove blood clots. Recently, a role for t-PA in the brain was discovered where under pathological conditions it can promote ischaemic and excitotoxic brain injury. This project will examine the mechanisms by which t-PA promotes injury to brain cells. It is anticipated that results obtained could be used to devise a means to reduce t-PA toxicity in the brain that would be of therapeutic benefit for patients with ischaemic stroke.