Developing Irreversible Electroporation Non-Thermal Tumor Ablation For Organ-Confined Prostate Cancer Treatment
Funder
National Health and Medical Research Council
Funding Amount
$290,512.00
Summary
IRE is technique for targeted tissue ablation. Electrodes placed into the targeted area deliver intense, brief electric pulses. Nano-scale pores are created in the cell membrane killing the cells but preserving the extracellular matrix. The pulses do not affect sensitive structures including neurovascular bundles, major vasculature and ductal systems preserving their function. It may address prostate regions implicated in prostate cancer without damaging vital structures, reducing side effects.
Targeting Hypermutable ‘superbugs’ In Chronic Respiratory Infections By Optimised Antibiotic Combination Dosage Regimens
Funder
National Health and Medical Research Council
Funding Amount
$697,731.00
Summary
Many bacterial ‘superbugs’ can increase their mutation rate, i.e. become hypermutable, and thus rapidly become resistant to multiple antibiotics. Chronic lung infections with hypermutable bacteria cause increased ill-health and death in patients and current treatments do not work well. We will develop improved treatments using combinations of available antibiotics. This project will provide guidance to doctors on how to treat infections more effectively and minimise emergence of resistance.
Improving The Therapeutic Use Of Anti-infective Agents: Application Of Pharmacometrics For Rational Dosing Regimen Design
Funder
National Health and Medical Research Council
Funding Amount
$313,390.00
Summary
There is no field of medicine in which the individualisation of medicines is more important than in infectious diseases – appropriate doses must be administered to maximise efficacy and to minimise side effects and the emergence of drug-resistance. This fellowship will use the emerging science of pharmacometrics to investigate factors contributing to the variability in response to anti-infective medications and to optimise dosing regimens for the best use of these drugs in clinical practice.
Combating Bacterial 'superbugs' By Innovative Antibiotic Combination Strategies
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
Resistant bacteria are among the 3 most serious threats to human health. This project will substantially improve our quantitative understanding of how bacteria survive antibiotics and enable the design of innovative antibiotic combination therapies to combat resistant ‘superbugs’. My research outcomes will inform clinicians how to optimally use available antibiotics and greatly support rational development and optimisation of new antibiotics in collaboration with pharmaceutical industry.
The Pharmacokinetic, Pharmacodynamic And Pharmacogenomic Outcomes Of Reduced Dosage Of Efavirenz: The Encore1 Study
Funder
National Health and Medical Research Council
Funding Amount
$1,234,943.00
Summary
Our primary aim is to assess blood concentrations of a drug called efavirenz, an important drug used in the treatment of HIV infection and associate these with variability of genes that control metabolism of the drug. A better understanding of gene variability and how it relates to safety and efficacy outcomes at a reduced, compared to a standard dose of efavirenz could support improved treatment of HIV disease.
Redefining Antibiotic Dosing To Reduce Bacterial Resistance
Funder
National Health and Medical Research Council
Funding Amount
$474,513.00
Summary
>3000 Australians die every year from severe infections (nearly 3-fold higher in number than our annual road toll). These treatment failures are due to sub-optimal antibiotic dosing from a poor understanding of why concentrations are different in these patients. I will use my laboratory to define what antibiotic concentrations we need to achieve and perform clinical studies with my collaborative network to demonstrate that we can redefine antibiotic dosing to reduce the emergence of superbugs ....>3000 Australians die every year from severe infections (nearly 3-fold higher in number than our annual road toll). These treatment failures are due to sub-optimal antibiotic dosing from a poor understanding of why concentrations are different in these patients. I will use my laboratory to define what antibiotic concentrations we need to achieve and perform clinical studies with my collaborative network to demonstrate that we can redefine antibiotic dosing to reduce the emergence of superbugs.Read moreRead less
Bioresponsive Nanocarriers For Controlled And Targeted Delivery To Efficiently Treat Inflammatory Bowel Disease (IBD)
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
Despite considerable progress in treatment of Inflammatory Bowel Diseases, current treatments suffer from many disadvantages such as side effects, lack of efficacy in many patients, and development of drug dependence. Using state of art nanotechnology, novel nanoparticles will be developed to enhance the delivery to the intestine and efficacy of Budesonide (an anti-inflammatory steroid). This research promises to find safer and more effective ways to treat these diseases.
Optimizing Outpatient Parenteral Antibiotic Therapy To Support Hospital-in-the-home Program Across The Unique Environmental Conditions Of Australia
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
This project aims to solve problems associated with stability and dosing of antibiotic infusions given to patients in their homes, to support decision making by doctors and regulators. Currently, there is a lack of adequate data that complies with contemporary requirements. We will study infusion preparation both in laboratory settings and in ‘real-life’ conditions while being used by patients. We will enhance the stability of antibiotic preparations and optimize doses for effective treatment.
Discovery Early Career Researcher Award - Grant ID: DE240100042
Funder
Australian Research Council
Funding Amount
$339,237.00
Summary
Hybrid optimisation for coordinating autonomous trucks and drones. This project aims to build analytics for controlling a fleet of autonomous trucks and drones working in tandem to deliver retail goods and disaster relief. This project expects to develop new mathematical and artificial intelligence algorithms for routing and scheduling the vehicles and for directing the multi-modal transfer of goods between vehicles in real-time as traffic conditions change. Expected outcomes of this project inc ....Hybrid optimisation for coordinating autonomous trucks and drones. This project aims to build analytics for controlling a fleet of autonomous trucks and drones working in tandem to deliver retail goods and disaster relief. This project expects to develop new mathematical and artificial intelligence algorithms for routing and scheduling the vehicles and for directing the multi-modal transfer of goods between vehicles in real-time as traffic conditions change. Expected outcomes of this project include new theories and technologies that enable a central computer to remotely control the autonomous fleet for maximum efficiency. Benefits in transport and logistics include improved freight productivity through reducing costs and delivery times.Read moreRead less