ARC Research Network on Intelligent Sensors, Sensor Networks and Information Processing. Sensor networks, a collection of diverse sensors interconnected via an ad-hoc communication network, are identified as one of the key technologies that over the next two decades will change the way we live. This research network brings together an interdisciplinary team of outstanding Australian researchers representing all the key disciplines required to successfully deploy sensor networks and links this te ....ARC Research Network on Intelligent Sensors, Sensor Networks and Information Processing. Sensor networks, a collection of diverse sensors interconnected via an ad-hoc communication network, are identified as one of the key technologies that over the next two decades will change the way we live. This research network brings together an interdisciplinary team of outstanding Australian researchers representing all the key disciplines required to successfully deploy sensor networks and links this team with the foremost international authorities and leading industry players in the area of sensor networks. This research network will guide collaborative research that will ensure Australia to play a world leading role in sensor network development and implementation.
Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346878
Funder
Australian Research Council
Funding Amount
$190,000.00
Summary
GeoWulf: An Inference Engine for Complex Earth Systems. The project is to build a `Beowulf' cluster as a platform for solving
complex data inference problems in the Earth sciences, and in
particular the fields of thermochronology, seismology, crustal and
mantle dynamics, and landform evolution. A Beowulf cluster is a
network-linked set of commonly available `off-the-shelf' PC-computers
configured to give unprecedented performance/cost ratio. Projects
using the Beowulf facility will combine ....GeoWulf: An Inference Engine for Complex Earth Systems. The project is to build a `Beowulf' cluster as a platform for solving
complex data inference problems in the Earth sciences, and in
particular the fields of thermochronology, seismology, crustal and
mantle dynamics, and landform evolution. A Beowulf cluster is a
network-linked set of commonly available `off-the-shelf' PC-computers
configured to give unprecedented performance/cost ratio. Projects
using the Beowulf facility will combine state-of-the-art computational
techniques recently developed at ANU, and high quality data sets
collected over the past decade to address fundamental questions in
the Geosciences.Read moreRead less
Optimising seasonal decisions for environmental water use. This project will develop a tool to optimise the use of environmental water, drawing on seasonal forecasts of streamflow and water price, and predicted ecological responses to changing flows. This tool will strengthen the effectiveness of the government organisations responsible for managing Australia's environmental water reserves.
Industrial Transformation Training Centres - Grant ID: IC200100009
Funder
Australian Research Council
Funding Amount
$4,861,236.00
Summary
ARC Training Centre in Optimisation Technologies, Integrated Methodologies, and Applications (OPTIMA). OPTIMA addresses industry’s urgent need for decision-making tools for global competitiveness: reducing lead times, and financial and environmental costs, while improving efficiency, quality, and agility. Despite strong expertise in academia, industry is yet to fully benefit from optimisation technology due to its high barrier to entry. Connecting industry partners with world-leading interdiscip ....ARC Training Centre in Optimisation Technologies, Integrated Methodologies, and Applications (OPTIMA). OPTIMA addresses industry’s urgent need for decision-making tools for global competitiveness: reducing lead times, and financial and environmental costs, while improving efficiency, quality, and agility. Despite strong expertise in academia, industry is yet to fully benefit from optimisation technology due to its high barrier to entry. Connecting industry partners with world-leading interdisciplinary researchers and talented students, OPTIMA will advance an industry-ready optimisation toolkit, while training a new generation of industry practitioners and over 120 young researchers, vanguarding a highly skilled workforce of change agents for transformation of the advanced manufacturing, energy resources, and critical infrastructure sectors.Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Humanisation And Pre-clinical Validation Of A Therapeutic Anti-cancer Antibody
Funder
National Health and Medical Research Council
Funding Amount
$699,136.00
Summary
This grant will develop a novel antibody against a protease expressed on cancer cells. Preclinical studies, and antibody humanisation, will be performed. This project will also provide vital information on optimal therapeutic approaches with the antibody that can be ultimately taken into human trials.
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
Low emission road transportation: harnessing the potential of alternative fuels and advanced vehicle technologies through online optimisation. This project will develop fundamental mathematical theory and use it to enable the best possible CO2 reduction capability in road vehicles. The cost of different technologies and fuels will then be compared to determine the most cost effective approaches to reduce road transport emissions.