Brain sodium channel: functional role of developmentally regulated alternative splicing. This project will identify the roles of neonatal and adult forms of a sodium channel in the function of neurons in the developing brain. Sodium channels are vital for brain function and this study will improve our understanding of the function of healthy brain as well as of underlying mechanisms of some neurological disorders.
How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understandi ....How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understanding the dynamics of developmental systems that shape complex brain traits includes establishing new developmental paradigms in evolutionary theory, generating new tools to investigate and manipulate brain gene expression in vivo, and the potential discovery of the causes of neurodevelopmental dysfunction.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668246
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Advanced Cell Labelling and Imaging Facility. Understanding the genetic regulation of cellular processes such as migration, differentiation and growth is an important frontier technology with significant biomedical potential. The Australian community is facing an increasing need to provide solutions for a variety of human diseases and disorders, including birth defects, nervous system injury and stroke, and ageing-related conditions. The proposed facility will allow researchers to test in vivo g ....Advanced Cell Labelling and Imaging Facility. Understanding the genetic regulation of cellular processes such as migration, differentiation and growth is an important frontier technology with significant biomedical potential. The Australian community is facing an increasing need to provide solutions for a variety of human diseases and disorders, including birth defects, nervous system injury and stroke, and ageing-related conditions. The proposed facility will allow researchers to test in vivo gene/pharmaceutical therapies as well as to better understand the genetic regulation of normal cellular processes. Read moreRead less
From rehabilitation to recovery after stroke : a model to optimise consumer and carer involvement. The National Research Priorities include 'ageing well, ageing productively'. Within this priority, it is necessary to be inclusive of those who have ongoing disabilities and/or chronic disease. This project aims to facilitate healthy lifestyles and community involvement in a group who have significant barriers to achieving their potential. The high incidence of depression and poor quality of life i ....From rehabilitation to recovery after stroke : a model to optimise consumer and carer involvement. The National Research Priorities include 'ageing well, ageing productively'. Within this priority, it is necessary to be inclusive of those who have ongoing disabilities and/or chronic disease. This project aims to facilitate healthy lifestyles and community involvement in a group who have significant barriers to achieving their potential. The high incidence of depression and poor quality of life in stroke survivors and their carers emphasises the need to enhance wellness in these people. The study will develop a model for promoting recovery and community reintegration in stroke survivors, with the goal of enabling stroke survivors and their carers to actively participate in the community and pursue personal goals.Read moreRead less