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Status : Active
Australian State/Territory : VIC
Research Topic : THERAPY
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  • Researchers (23)
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  • Active Funded Activity

    Targeting Iron Piracy From Host Proteins By Neisseria And Haemophilus Spp. For The Development Of Novel Antimicrobials

    Funder
    National Health and Medical Research Council
    Funding Amount
    $645,205.00
    Summary
    The bacteria that cause the sexually transmitted infection gonorrhoea and meningococcal disease are a serious health concern. In order to cause disease, these bacteria must obtain the nutrient iron from our bodies. This proposed research will use cutting edge technologies to understand on a molecular level how these bacteria obtain iron during infection. It will then apply this knowledge to develop molecules that prevent these bacteria from obtaining iron, as a means of treating these diseases.
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    Active Funded Activity

    Discovery Projects - Grant ID: DP200103093

    Funder
    Australian Research Council
    Funding Amount
    $449,250.00
    Summary
    How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understandi .... How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understanding the dynamics of developmental systems that shape complex brain traits includes establishing new developmental paradigms in evolutionary theory, generating new tools to investigate and manipulate brain gene expression in vivo, and the potential discovery of the causes of neurodevelopmental dysfunction.
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    Active Funded Activity

    Discovery Projects - Grant ID: DP190102978

    Funder
    Australian Research Council
    Funding Amount
    $425,291.00
    Summary
    Social cohesion and resilience through intercultural music engagement. This project aims to identify, evaluate and develop theoretical and practical ways in which intercultural music engagement can facilitate social cohesion and enhance community resilience and intercultural empathy. There is growing evidence that music is a powerful stimulus for wellbeing and interpersonal connection and it is increasingly applied to promote intercultural understanding. This project will use detailed observatio .... Social cohesion and resilience through intercultural music engagement. This project aims to identify, evaluate and develop theoretical and practical ways in which intercultural music engagement can facilitate social cohesion and enhance community resilience and intercultural empathy. There is growing evidence that music is a powerful stimulus for wellbeing and interpersonal connection and it is increasingly applied to promote intercultural understanding. This project will use detailed observational, participatory and experimental strategies to elucidate the psychosocial processes underpinning intercultural music engagement, isolating variables that promote social cohesion. The project will develop best practice guidelines for organisations seeking to use cultural exposure and interaction to promote positive multicultural experiences.
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    Active Funded Activity

    ARC Future Fellowships - Grant ID: FT190100266

    Funder
    Australian Research Council
    Funding Amount
    $767,725.00
    Summary
    Programmed cell death signalling in innate immunity. This proposal aims to address the under-explored potential for programmed cell death to promote innate immune cell signalling, which is a critical and fundamental biological process. It aims to generate new knowledge in the areas of cell death and innate signalling using innovative interdisciplinary approaches and discover new molecules that impact innate inflammatory responses. The expected outcomes of this project are to enhance our basic un .... Programmed cell death signalling in innate immunity. This proposal aims to address the under-explored potential for programmed cell death to promote innate immune cell signalling, which is a critical and fundamental biological process. It aims to generate new knowledge in the areas of cell death and innate signalling using innovative interdisciplinary approaches and discover new molecules that impact innate inflammatory responses. The expected outcomes of this project are to enhance our basic understanding of cell death, and build interdisciplinary collaborations. This work should provide significant benefit to the economy and health of Australians, as it is expected to identify molecules that will be of interest to the pharmaceutical and biotechnology industries.
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    Active Funded Activity

    Linkage Projects - Grant ID: LP210200125

    Funder
    Australian Research Council
    Funding Amount
    $412,919.00
    Summary
    Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a .... Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.
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    Active Funded Activity

    Discovery Projects - Grant ID: DP200100499

    Funder
    Australian Research Council
    Funding Amount
    $415,000.00
    Summary
    Prediction of phenotype for multiple traits from multi-omic data. This project aims to develop better methods for predicting traits in an individual based on their genome sequence. This method will be tested in agricultural animals and plants and in humans. The prediction formula is derived from a training dataset that has information on the traits and genome sequence of a sample of individuals. The prediction formula can then be applied to predict the trait in individuals where the trait is un .... Prediction of phenotype for multiple traits from multi-omic data. This project aims to develop better methods for predicting traits in an individual based on their genome sequence. This method will be tested in agricultural animals and plants and in humans. The prediction formula is derived from a training dataset that has information on the traits and genome sequence of a sample of individuals. The prediction formula can then be applied to predict the trait in individuals where the trait is unknown. This is useful for selecting the best parents for breeding in agriculture and for predicting the future phenotype of animals, crops and people. The proposed method uses data on very many traits to identify sequence variants that have a function and to predict the traits affected by each variant.
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