Optimizing The Management Of Osteoarthritis Through Research And Innovation
Funder
National Health and Medical Research Council
Funding Amount
$2,889,164.00
Summary
I will test new treatments aimed at slowing disease progression and reducing pain in osteoarthritis (OA) by targeting specific disease pathways (metabolic factors and inflammation). I will undertake work examining the causes of hip OA where little is known. All required methodologies and resources to undertake this work are available and the trials underpinned by strong scientific rationale. This research program has high potential for translation and for reducing the burden and cost of OA.
Hearing, social connectedness, and well-being of ageing adults in Australia. Hearing ability declines with age and hearing loss has a fundamental impact on an adult’s ability to communicate and, in turn, socially connect with others. This benchmark study aims to apply innovative, quantitative and qualitative methods to examine the real-world social connections of adults with hearing loss who use or do not use hearing aids. This project expects to increase understanding of the social impacts of a ....Hearing, social connectedness, and well-being of ageing adults in Australia. Hearing ability declines with age and hearing loss has a fundamental impact on an adult’s ability to communicate and, in turn, socially connect with others. This benchmark study aims to apply innovative, quantitative and qualitative methods to examine the real-world social connections of adults with hearing loss who use or do not use hearing aids. This project expects to increase understanding of the social impacts of age-related hearing loss and the relationship to hearing rehabilitation. The expected outcomes have the potential to guide research, policy, and practice for ageing Australians. This should provide significant benefits, such as reducing social isolation and enhancing the well-being of millions of Australians.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100827
Funder
Australian Research Council
Funding Amount
$458,737.00
Summary
Delineating the developmental requirements for stem-like T cells. Stem-like CD8 T cells are critical for sustaining long-term systemic T cell activity. The signalling required for their development, however, remains elusive. Integrating multidisciplinary expertise, cutting-edge technology and highly innovative methods, this project aims to define the signalling cues provided by tissue microenvironment that control the development and maintenance of stem-like T cells, and thereby dictate systemic ....Delineating the developmental requirements for stem-like T cells. Stem-like CD8 T cells are critical for sustaining long-term systemic T cell activity. The signalling required for their development, however, remains elusive. Integrating multidisciplinary expertise, cutting-edge technology and highly innovative methods, this project aims to define the signalling cues provided by tissue microenvironment that control the development and maintenance of stem-like T cells, and thereby dictate systemic immunity. This project is expected to generate fundamental knowledge on basic immunology and T cell biology, which can benefit the academic, public health and biotechnology sectors by enhancing the international standing of Australian research on basic immunology and fostering new commercial opportunities. Read moreRead less
Sibling influence on development of children with autism spectrum disorder. This project aims to investigate how typically-developing siblings affect the development of children with autism spectrum disorder (ASD). ASD involves difficulties with language, executive functions and social understanding. For typically-developing children, growing up with siblings gives an advantage in these cognitive functions. Yet little is known about how having siblings’ impacts on cognitive development of childr ....Sibling influence on development of children with autism spectrum disorder. This project aims to investigate how typically-developing siblings affect the development of children with autism spectrum disorder (ASD). ASD involves difficulties with language, executive functions and social understanding. For typically-developing children, growing up with siblings gives an advantage in these cognitive functions. Yet little is known about how having siblings’ impacts on cognitive development of children with ASD. The project intends to longitudinally explore the mechanisms of sibling impact in families with and without a child with ASD. The outcomes will deepen understanding of child development, providing an evidence base for effective interventions to increase child competence and aiming ultimately to reduce the social costs of ASD.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101494
Funder
Australian Research Council
Funding Amount
$418,280.00
Summary
'There's no place like home': optimising the home environment to age well. This project aims to create new knowledge and digital tools for older people to be able to assess their home for access and safety, and arrange modifications enabling them to remain in their own home for as long as possible. Most older people wish to remain in their own home but often require home modifications in order to do so, which are traditionally prescribed by occupational therapists. The expected outcome of this p ....'There's no place like home': optimising the home environment to age well. This project aims to create new knowledge and digital tools for older people to be able to assess their home for access and safety, and arrange modifications enabling them to remain in their own home for as long as possible. Most older people wish to remain in their own home but often require home modifications in order to do so, which are traditionally prescribed by occupational therapists. The expected outcome of this project includes new digital tools which will enable optimal adaptation of the home environment. This should provide significant social benefits, such as increased safety, independence and support for older people to remain at home, and economic benefits from a reduced need for residential aged care or health services.Read moreRead less
Poly(amino acids) as immune stimulators. This project aims to develop nanoparticles built from natural hydrophobic amino acids as an immune stimulatory delivery system for peptide antigens. Currently available immune stimulants (adjuvants) are often toxic and/or are poorly chemically defined fragments of bacteria or toxins and vary from batch-to-batch. New adjuvants are in high demand; especially to facilitate the use of optimal, but weakly immunogenic, peptide antigens. It is expected that the ....Poly(amino acids) as immune stimulators. This project aims to develop nanoparticles built from natural hydrophobic amino acids as an immune stimulatory delivery system for peptide antigens. Currently available immune stimulants (adjuvants) are often toxic and/or are poorly chemically defined fragments of bacteria or toxins and vary from batch-to-batch. New adjuvants are in high demand; especially to facilitate the use of optimal, but weakly immunogenic, peptide antigens. It is expected that the proposed project will develop a novel efficient, safe and notably biodegradable self-adjuvanting delivery system that can be fully customised to match an antigen of choice. This foundational research should provide important advances for commercial immune stimulatory applications.Read moreRead less