First Principles Design of Second-Generation Protein Stains. Proteomics is an emerging technology which has the potential to revolutionize modern biology and medicine. Extremely sensitive protein stains are a key proteomics technology, and in conjunction with gel electrophoresis, they facilitate the rapid and quantitative detection of all polypeptides in a cell. However, the tools of proteomics must rapidly advance (cheaper, greater sensitivity, more reliable, safer to handle) before the techn ....First Principles Design of Second-Generation Protein Stains. Proteomics is an emerging technology which has the potential to revolutionize modern biology and medicine. Extremely sensitive protein stains are a key proteomics technology, and in conjunction with gel electrophoresis, they facilitate the rapid and quantitative detection of all polypeptides in a cell. However, the tools of proteomics must rapidly advance (cheaper, greater sensitivity, more reliable, safer to handle) before the technology can mature to the stage where its full potential is realized. We will enable the evolution of proteomics by devising second generation fluorescent protein stains, using the environmentally-friendly natural product, epicocconone, as our design platform.Read moreRead less
Persistent Triplet Carbenes. Viable or Not? Triplet carbenes have significant potential real world applications, such as in modern electronics. However, they are highly reactive (lifetimes typically < 1 day), and this has stymied their development. Can I design so called persistent triplet-carbenes, which have significant lifetimes? I will try to using computer chemistry. In doing so, I will provide synthetic chemists with 'high-value' targets for preparation, hence saving tax dollars and minimi ....Persistent Triplet Carbenes. Viable or Not? Triplet carbenes have significant potential real world applications, such as in modern electronics. However, they are highly reactive (lifetimes typically < 1 day), and this has stymied their development. Can I design so called persistent triplet-carbenes, which have significant lifetimes? I will try to using computer chemistry. In doing so, I will provide synthetic chemists with 'high-value' targets for preparation, hence saving tax dollars and minimizing creation of environmentally damaging waste. Read moreRead less
Voids in molecular crystals: Novel computational approaches to their characterization, physicochemical nature, and influence on bulk properties. Key to the research objectives is further development of our own innovative software and techniques, now used by hundreds of researchers worldwide for the visualization and exploration of the structure and properties of molecular crystals. Through involvement of postdoctoral fellows and PhD students in an international collaborative research program inv ....Voids in molecular crystals: Novel computational approaches to their characterization, physicochemical nature, and influence on bulk properties. Key to the research objectives is further development of our own innovative software and techniques, now used by hundreds of researchers worldwide for the visualization and exploration of the structure and properties of molecular crystals. Through involvement of postdoctoral fellows and PhD students in an international collaborative research program involving a synergy between software development and visualization, and sophisticated modelling of the detailed nature of molecular crystals, the project contributes directly to producing researchers familiar with state-of-the-art theoretical and computational techniques, and well equipped to match the needs of one of the nation's articulated research priorities.Read moreRead less
Computational Nanofluidics. This project will generate an increased level of skill and expertise in Australia in the emerging science of nanotechnology. To realise the promise of nanotechnology, a means of controlled propulsion on the nano scale is vital. A deeper understanding of nanofluidics that allows greater predictive capacities can greatly aid this realisation. It is highly likely that computational nanofluidics will play as important a role in nanotechnology based industries as computat ....Computational Nanofluidics. This project will generate an increased level of skill and expertise in Australia in the emerging science of nanotechnology. To realise the promise of nanotechnology, a means of controlled propulsion on the nano scale is vital. A deeper understanding of nanofluidics that allows greater predictive capacities can greatly aid this realisation. It is highly likely that computational nanofluidics will play as important a role in nanotechnology based industries as computational fluid dynamics (CFD) currently plays in today's manufacturing, automotive and aerospace industries. The skills and knowledge gained from this project will enhance our international competitiveness in this area. Read moreRead less
Many-body problems. The discovery of new superheavy elements, chemical evolution of the Universe, nuclear reactions deep under the Coulomb barrier in nuclear reactors, in stars and during the Big Bang Nucleosynthesis, accuracy of precise atomic clocks, consistency of the Standard Model in strong fields are among the most vital problems of modern science. This project suggests several new ideas in these areas, which are based on knowledge accumulated in different research fields. The outcomes of ....Many-body problems. The discovery of new superheavy elements, chemical evolution of the Universe, nuclear reactions deep under the Coulomb barrier in nuclear reactors, in stars and during the Big Bang Nucleosynthesis, accuracy of precise atomic clocks, consistency of the Standard Model in strong fields are among the most vital problems of modern science. This project suggests several new ideas in these areas, which are based on knowledge accumulated in different research fields. The outcomes of the research will help Australia to build up a "critical mass" of scientific expertise, which is necessary to place and keep it among leaders in these frontier areas of physics, and to train the next generation of experts in these fields.Read moreRead less
Quantum and Geometric Aspects of Gauge Theories, Supergravity and String Theory. A central problem of modern high-energy physics is the unification of gravity with the other fundamental interactions that is consistent at the quantum level. Led by a team of internationally recognized experts, this project will yield breakthroughs in supergravity and string theory - crucial ingredients of current approaches to unification. As well as putting Australia at the forefront of this mainstream activity, ....Quantum and Geometric Aspects of Gauge Theories, Supergravity and String Theory. A central problem of modern high-energy physics is the unification of gravity with the other fundamental interactions that is consistent at the quantum level. Led by a team of internationally recognized experts, this project will yield breakthroughs in supergravity and string theory - crucial ingredients of current approaches to unification. As well as putting Australia at the forefront of this mainstream activity, a fertile environment will be provided for the training of graduate students. They will be ideally placed to lead Australia's involvement in the revolution sparked by the expected experimental confirmation of supersymmetry with the Large Hadron Collider. Read moreRead less
Progress in Supersymmetry and Supergravity: Continuing Einstein's Legacy. 2005 is the International Year of Physics in recognition of Einstein's revolutionary contributions. His unfinished quest for a unified description of Nature has become the hottest topic in modern physics. Led by a team of internationally recognized experts, this project will yield breakthroughs in supersymmetry and supergravity - crucial ingredients of current approaches to unification. As well as putting Australia at the ....Progress in Supersymmetry and Supergravity: Continuing Einstein's Legacy. 2005 is the International Year of Physics in recognition of Einstein's revolutionary contributions. His unfinished quest for a unified description of Nature has become the hottest topic in modern physics. Led by a team of internationally recognized experts, this project will yield breakthroughs in supersymmetry and supergravity - crucial ingredients of current approaches to unification. As well as putting Australia at the forefront of this mainstream activity, a fertile environment will be provided for the training of graduate students. They will be ideally placed to lead Australia's involvement in the revolution sparked by the expected experimental confirmation of supersymmetry with the next generation of particle accelerators.Read moreRead less
Low Energy Effective Actions in Supersymmetric Gauge Theories. The quest for a unified quantum theory of all the fundamental interactions of Nature, including gravity, is a major goal of modern physics. Superstring theory is at present the only plausible candidate. This theory makes nontrivial predictions (non-renormalization theorems) about the low energy structure of certain supersymmetric gauge theories (the Standard Model of particle physics is a special gauge theory). This project will deve ....Low Energy Effective Actions in Supersymmetric Gauge Theories. The quest for a unified quantum theory of all the fundamental interactions of Nature, including gravity, is a major goal of modern physics. Superstring theory is at present the only plausible candidate. This theory makes nontrivial predictions (non-renormalization theorems) about the low energy structure of certain supersymmetric gauge theories (the Standard Model of particle physics is a special gauge theory). This project will develop new tools for the computation of low energy effective actions, which will then be used for a detailed analysis of the non-renormalization theorems governing the low energy dynamics of supersymmetric gauge theories. This research is at the forefront of modern particle physics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347499
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Development of a High Performance Computing Cluster for ac3 Research. This application proposes the development of a 350 Gflop Beowulf parallel computing cluster that will support high profile research of international significance, spanning the science and technology spectrum, and according with national priority areas identified by Government and the ARC. The facility will provide an urgently needed boost in both aggregate and peak HPC capacity in NSW, thereby facilitating the solution of the ....Development of a High Performance Computing Cluster for ac3 Research. This application proposes the development of a 350 Gflop Beowulf parallel computing cluster that will support high profile research of international significance, spanning the science and technology spectrum, and according with national priority areas identified by Government and the ARC. The facility will provide an urgently needed boost in both aggregate and peak HPC capacity in NSW, thereby facilitating the solution of the next generation of computational research problems. In doing so, it will underpin innovation by world ranking groups in diverse fields such as photonics, complex/intelligent systems, nanotechnology, bioinformatics, quantum physics and chemistry, engineering, and environmental modelling.Read moreRead less