Deep Brain Stimulation For Severe Generalised Epilepsy Of Lennox-Gastaut Phenotype
Funder
National Health and Medical Research Council
Funding Amount
$897,972.00
Summary
Deep Brain stimulation (DBS) is an emerging treatment for epilepsy, recently approved for use in Australia on the basis of trials in focal epilepsy showing benefit. The role of DBS in generalised epilepsy is currently unclear. This study tests the effectiveness of DBS in Lennox-Gastaut Syndrome, a severe, medication-resistant generalised epilepsy syndrome.
A Role For The Pulvinar Nucleus In Visual Cortical Development And Plasticity
Funder
National Health and Medical Research Council
Funding Amount
$844,435.00
Summary
This project will investigate a part of the brain responsible for processing visual information, the pulvinar. This area has received little attention but has more recently been associated with the capacity for infants to recover vision following injuries such as stroke, as well as in mental health conditions such as schizophrenia. We will take a cell-to-system approach to uncover how this area develops and modulates the processing of visual information.
The Pulvinar Is Instrumental In The Development Of Visual Cortical Networks
Funder
National Health and Medical Research Council
Funding Amount
$1,192,911.00
Summary
This Project will elucidate the mechanisms and brain structures involved in visual system development and how their perturbation in early life can lead to neurodevelopmental and cognitive brain disorders, such as Williams and fragile-X syndromes as well as dyslexia. Furthermore, it will demonstrate how the visual brain has a greater capacity to compensate and achieve preservation of vision following an injury in early life.
Underlying Mechanims Of Thalamocortical Dysrhythmia In Chronic Pain
Funder
National Health and Medical Research Council
Funding Amount
$393,817.00
Summary
Pain has a detrimental impact on ones quality of life and a significant financial impact on the community. It has recently been revealed that chronic pain is associated with altered electrical rhythms within the brain. Using human brain imaging, we aim to determine the underlying reason for this altered rhythm in humans with pain resulting from nervous system damage. Defining this mechanism will aid in the development of better treatment regimes.
Interaction Of Thalamic And Cortical Activity In The Primate Visual System
Funder
National Health and Medical Research Council
Funding Amount
$487,580.00
Summary
We recently discovered that a primitive part of the visual pathway shows rhythmic nerve cell activity similar to slow brain waves recorded in sleep, anaesthesia, and epilepsy. We now plan to discover whether these primitive cells help to generate brain waves by measuring the timing of their activity together with brain waves in different visual and non-visual parts of the brain. This project will contribute to understanding the role of brain waves in normal brain function and epilepsy.