ARDC Research Link Australia

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $196,527.00
Summary: We have recently isolated a novel gene (Crim1) and shown it to be strongly expressed during eye development. Its protein structure indicates that it may act to regulate the activities of two growth factor families, the TGF superfamily and the insulin-IGFs. These growth factors effect the behaviour of many cell types that influence events in normal and pathological development. For example in the eye lens, TGF 1 can induce cataractous changes in epithelial cells and early differentiating fibres; ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $7,580,681.00
Summary: Achieving the goal of reproductive health for all is a public health issue and is limited by factors including, problems of infertility, inadequacies of the fertility-regulating methods and the high incidence of reproductive tract diseases, including cancers. The overall objective of this Program Grant is to discover, understand and apply new knowledge about reproductive processes in health and disease to alleviating infertility, improving contraceptive choice and efficacy and combating diseases ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $265,500.00
Summary: Immunoreceptors play an important role in balancing the threshold of cellular activation is critical in the immune response to tumours, pathogens or allergens, to arrest autoimmune and infectious disease and to provoke immunological memory to vaccination. We have discovered that Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1-CD31) is a new immunoreceptor, that belongs to a very important family of proteins, the Ig-ITIM superfamily which is a subset of the immunoglobulin superfamily. We w ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $322,911.00
Summary: Several years ago we identified the cell membrane protein PETA-3-CD151 based on its ability to cause activation of blood platelets, suggesting a role in thrombosis. More recently we found that the protein is present in a variety of tissues, although its distribution in those tissues is often restricted. It is abundant in a variety of cancer cells, and is present on tissue mast cells that mediate allergic reactions. PETA-3-CD151 forms complexes with molecules (integrins) that are associated with ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $367,669.00
Summary: White blood cells are the army which fights invasion by foreign organisms or cancer cells. Their main artillery and communication systems are located on the cell surface as protein molecules. These recognize foreign material and danger signals, and signal into the cell to direct interactions with other cells- soluble molecules in the immune system. We have discovered a new group of molecules called the CMRF-35 family which are found on the surface of different white blood cells. We have characte ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $309,536.00
Summary: Cytokines are hormone like messengers that mediate the interactions between cells. We have discovered a new cytokine that we have named macrophage inhibitory cytokine 1 (MIC-1). It belongs to a very important family of proteins that are involved in wound healing, development and inflammation. Our data thus far suggests that MIC-1 is an anti-inflammatory factor that is of particular relevance in rheumatoid arthritis. We wish to determine the relationship between the amount of this cytokine in the ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $507,270.00
Summary: Activin is a member of the TGF- family of growth and differentiation factors. Over-expression in mice leads to muscle and liver wasting, scarring during wound healing, disturbances to the reproductive system and various endocrine disorders. Activin's biological activity is promoted by its binding in series to two receptors termed Type I and II. Previous studies by this investigator have shown that selective modification of activin's protein structure can result in activin forms (in this instance ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $424,262.00
Summary: Liver damage after liver surgery or shock is called ischemia-reperfusion injury (IRI). Recovery after surgical removal of liver tissue is due to liver regeneration. IRI and liver regeneration are controlled by specialised proteins called cytokines, one of which, TRAIL, is essential for both IRI and liver regeneration. This research is to find out how TRAIL exerts such seemingly opposite effects. The aim is to learn how to protect the liver against damage, and to stimulate its recovery.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $377,036.00
Summary: Asthma is a disease characterised by excessive narrowing of the airway tubes resulting in difficulty exhaling air from the lungs. Symptoms of asthma include coughing, wheezing, shortness of breath and difficulty in breathing. Asthma affects almost 1 in 5 Australians and is especially prevelant in children. One in every three Australians will suffer from symptoms of asthma at some time in their life and despite current therapy, asthma is responsible for the deaths of more than 700 Australians eve ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $280,430.00
Summary: Cytokines are hormone like messengers that mediate the interactions between cells. We have discovered a new cytokine that we have named macrophage inhibitory cytokine 1 (MIC-1). It belongs to a very important familty of proteins that are involved in wound healing, development and inflammation. Our data thus far suggest thatMIC-1 is an antiinflammatory factor that also involved in reproduction, especially in the health of the placenta. To determine the accuracy of these predictions we wish to use ....
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