Enhancing The Blood-brain Barrier Efflux Of ?-amyloid: A Novel Approach For The Treatment Of Alzheimer’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$291,274.00
Summary
Alzheimer’s disease (AD) is the leading cause of dementia and is associated with the accumulation of a toxic protein in the brain. This project will investigate whether enhancing the removal of this toxic protein from the brain (by shuttling it into the blood) will restore the memory deficit associated with AD. The outcomes of this project have the potential to lead to novel strategies for the treatment of this debilitating disorder.
Exploring The Pluridimensionality Of Drug Efficacy.
Funder
National Health and Medical Research Council
Funding Amount
$326,184.00
Summary
Dysfunction of cell surface receptors is the underlying cause of many pathological conditions. Using cell based screening methods we aim to investigate the mechanisms underlying drug action, to understand how drugs acting at common targets promote distinct biological responses. This will aid the development of new therapeutics based on the ability to predict specific drug effects.
Glucocorticoid Resistance: Identifying New Anti-inflammatory Drug Targets
Funder
National Health and Medical Research Council
Funding Amount
$453,287.00
Summary
The control of chronic inflammatory diseases such as asthma involve use of drugs related to the steroid hormone cortisol. Up to 40% of patients with more severe disease respond poorly or not at all to these drugs. The remaining non-steroid treatments are only partially effective. Poor disease control is a great health and economic burden. We have identified a molecular mechanism for steroid resistance and propose new studies to identify novel drugs that act to reverse steroid resistance.