Expansion Of TGF-beta-Smad Signaling Network And Intrinsic Epithelial-mesenchymal-endothelial Transition
Funder
National Health and Medical Research Council
Funding Amount
$557,297.00
Summary
The majority of tumor death occurs due to tumor metastasis. Both tumor growth and tumor spread require angiogenesis, which is thought to be driven by tumor but originated from host endothelial cells. Could tumor cells behave and function like endothelial cells? This application aims to detect the transition of adult epithelial cells to endothelial cells through a transient mesenchymal state. Our studies should reveal both the molecular and cellular causes of vasculogenic mimicry, thus establishi ....The majority of tumor death occurs due to tumor metastasis. Both tumor growth and tumor spread require angiogenesis, which is thought to be driven by tumor but originated from host endothelial cells. Could tumor cells behave and function like endothelial cells? This application aims to detect the transition of adult epithelial cells to endothelial cells through a transient mesenchymal state. Our studies should reveal both the molecular and cellular causes of vasculogenic mimicry, thus establishing a new paradigm in understanding tumor growth and metastasis. Such novel molecular understanding will open up new anti-tumor therapeutic opportunities.Read moreRead less
Mechanisms Responsible For Pancreatic Beta Cell Death And Dysfunction
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Diabetes is the fastest growing chronic disease both in Australia and worldwide. Current treatments are lacking effectiveness. Therefore, there is an urgent need to revolutionise diabetes therapy. Diabetes is caused by the failure of cells within the pancreas to produce sufficient insulin, resulting in uncontrolled blood sugar levels. This research proposal aims to investigate the processes and factors leading to this phenomenon in order to develop new strategies to overcome them.