Effect Of Testosterone Treatment Combined With Dietary Restriction On Body Fat Mass And Muscle Function In Obese Men: A Randomized Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$140,949.00
Summary
Obesity, an increasing health and economic burden, is associated with lowered testosterone levels in men. While both dietary restriction and testosterone treatment reduce body fat, whether a combination of these two approaches achieves a more pronounced fat mass reduction is unknown. We will conduct a rigorous 12 month clinical trial of testosterone treatment in 150 obese men with a low testosterone level. All men will receive dietary intervention to induce and maintain weight loss
Control Of Musculoskeletal Function And Glucose Metabolism By Androgens In Men
Funder
National Health and Medical Research Council
Funding Amount
$245,031.00
Summary
Male sex hormone or androgen deficiency (AD) is a common, but under-diagnosed condition. AD decreases general well being and contributes to muscle weakness, bone fragility and weight gain. By using cutting edge imaging and molecular technologies, we will help to explain the underlying mechanisms of how AD leads to these negative effects. This should ultimately lead to reduction of adverse outcomes of AD, which include fractures and cardiovascular events.
Effect Of Bisphosphonates On Bone Architecture And Glucose Metabolism In Men With Prostate Cancer Receiving Androgen Deprivation Therapy: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$566,215.00
Summary
Androgen deprivation therapy (ADT) is a type of hormonal treatment which is effective for prostate cancer treatment. However, ADT may cause bone fragility, weight gain, diabetes and heart disease. We will examine the effects of a bone strengthening treatment on bone structure and glucose metabolism in men receiving ADT. This trial should help in better define the risk benefit ratio of ADT, and therefore provide treating doctors with better guidance as to when and how to use this therapy.
The Effect Of Androgen Replacement Therapy On Bone And Muscle Health In Men With Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
Low testosterone (T) levels are common in men with poor kidney function. Low T is known to cause reduced energy, decreased strength and low libido. Normal T is also needed for healthy bones and muscles. Men with kidney disease are already at risk of fractures, poor strength and quality of life. However, there are few studies that look at replacing T to men with kidney failure. We will investigate how low T affects bone and muscle and assess how giving T can benefit bone, muscle and function.
Sex Hormones And Heart Disease In Older Women Study (The SHOW Study)
Funder
National Health and Medical Research Council
Funding Amount
$594,672.00
Summary
Cardiovascular disease (CVD, heart disease and stroke) is the leading cause of death in women aged 65 and over. Counter-intuitively, androgens may be as, or even more important, than estrogens in determining CVD risk and all-cause mortality in women, but this is yet to be verified. We will document blood levels of androgens in women aged 70+ and determine whether androgens are associated with CVD and death in this large cohort of elderly well women.