Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not re ....Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not respond to the current TNF treatments. Improved anti-TNF strategies would provide enhanced health outcomes and welcome relief to many Australians. In addition, the economic benefit of the TNF market is very substantial. Therefore the potential impact of this research is very high both for health care and economical potential.Read moreRead less
Rational structure-based drug design of protein tyrosine kinase inhibitors. Protein tyrosine kinases (PTK) are a large, pivotal family of signalling molecules implicated in diseases such as cancer and immune-related disorders, that cause significant morbidity and mortality within the population. This research proposal aims to develop PTK-specific small molecule inhibitors to combat such diseases. Cytopia's drug discovery capability, coupled with the X-ray crystallographic expertise within Monas ....Rational structure-based drug design of protein tyrosine kinase inhibitors. Protein tyrosine kinases (PTK) are a large, pivotal family of signalling molecules implicated in diseases such as cancer and immune-related disorders, that cause significant morbidity and mortality within the population. This research proposal aims to develop PTK-specific small molecule inhibitors to combat such diseases. Cytopia's drug discovery capability, coupled with the X-ray crystallographic expertise within Monash University, will permit a rational, structure-based drug discovery platform to be established. The ultimate goal of this innovative and mutlidisciplinary approach, namely a portfolio of phase I therapeutics, will be of substantial benefit in the medical health area.Read moreRead less
Rational structure-based drug design of protein tyrosine kinase inhibitors. This research project is focussed on understanding the physiological roles of a group of enzymes within the cell, as well as developing therapeutics to combat significant diseases. It will achieve this by developing compounds to enzymes that are implicated in the disease process. The research project represents a continuation of a collaboration between academic researchers at Monash University, and an Australian biotec ....Rational structure-based drug design of protein tyrosine kinase inhibitors. This research project is focussed on understanding the physiological roles of a group of enzymes within the cell, as well as developing therapeutics to combat significant diseases. It will achieve this by developing compounds to enzymes that are implicated in the disease process. The research project represents a continuation of a collaboration between academic researchers at Monash University, and an Australian biotechnology company, Cytopia Ltd.Read moreRead less
Studies of the pi3-kinase enzyme family using selective inhibitors. The objective of this project is to study the function of the PI3-kinase enzyme family in blood platelets. To do this, inhibitors which block the action of specific family members, will be evaluated for their effects in assays of platelet function. The results will enhance our understanding of the way in which platelets and other cells respond to stimuli, and lead new approaches to designing novel drugs that block these response ....Studies of the pi3-kinase enzyme family using selective inhibitors. The objective of this project is to study the function of the PI3-kinase enzyme family in blood platelets. To do this, inhibitors which block the action of specific family members, will be evaluated for their effects in assays of platelet function. The results will enhance our understanding of the way in which platelets and other cells respond to stimuli, and lead new approaches to designing novel drugs that block these responses.Read moreRead less
Novel modes of signalling of serotonin 5-HT2c receptors. This project focuses on a special family of receptor proteins that mediate the actions of the neurochemical, serotonin (5HT), in the human brain. These serotonin receptors are major targets for antidepressant and antipsychotic medications, and also play a role in anxiety, migraine and control of appetite. Despite the important role of serotonin receptors in health and disease, the mechanism of action of many drugs acting on these receptors ....Novel modes of signalling of serotonin 5-HT2c receptors. This project focuses on a special family of receptor proteins that mediate the actions of the neurochemical, serotonin (5HT), in the human brain. These serotonin receptors are major targets for antidepressant and antipsychotic medications, and also play a role in anxiety, migraine and control of appetite. Despite the important role of serotonin receptors in health and disease, the mechanism of action of many drugs acting on these receptors remains unknown. Our project will specifically investigate novel molecular mechanisms associated with serotonin receptor activity that may prove vital in understanding mechanisms of psychiatric illnesses, and how many psychiatric medicines actually work.Read moreRead less
Data Fusion Techniques for Electro-Mechanical Braking Systems. The main focus of this project is to develop data fusion techniques for clamp force estimation and optimum utilisation of redundant information in a brake-by-wire system. Efficient integration of redundant information in an EMB system is expected to significantly improve the reliability and fault tolerance of such systems. The need for costly and complicated clamp force measurement sensors in electric callipers will also be eliminate ....Data Fusion Techniques for Electro-Mechanical Braking Systems. The main focus of this project is to develop data fusion techniques for clamp force estimation and optimum utilisation of redundant information in a brake-by-wire system. Efficient integration of redundant information in an EMB system is expected to significantly improve the reliability and fault tolerance of such systems. The need for costly and complicated clamp force measurement sensors in electric callipers will also be eliminated by accurate estimation of the clamp force signal, through fusion of more readily available measurements. Development of the proposed data fusion techniques influences the design of future EMBs and enhances the functionality of existing brake-by-wire systems.Read moreRead less
Compositional determination of liquefied petroleum gas: Improving engine cold start performance in multipoint LPG-injected engines. Unlike gasoline, the composition of liquefied petroleum gas (LPG) is subject to change depending on a variety of factors including reservoir location and local market pricing. During normal automotive multipoint injection engine operation, closed loop feedback from engine sensors allows the effects of the compositional variations to be overcome and the engine to ope ....Compositional determination of liquefied petroleum gas: Improving engine cold start performance in multipoint LPG-injected engines. Unlike gasoline, the composition of liquefied petroleum gas (LPG) is subject to change depending on a variety of factors including reservoir location and local market pricing. During normal automotive multipoint injection engine operation, closed loop feedback from engine sensors allows the effects of the compositional variations to be overcome and the engine to operate close to optimal levels. However during cold start, the feedback sensors are not operational, and engine performance may deteriorate due to unknown fuel composition - in the worst case the engine may not start at all. This project aims to develop unique methods of estimating the composition of LPG based on existing sensor information to improve performance during cold start.Read moreRead less
Scalable Robust Video Surveillance over Constrained Networks. Real-time monitoring of large numbers of people is becoming increasingly important for applications such as efficient service delivery and security against both common crime and terrorism. The use of human operators for such tasks is infeasible due to the large amount of data collected. Existing autonomous video surveillance systems are prone to high numbers of false alarms and often require expensive hardware. This proposal seeks ....Scalable Robust Video Surveillance over Constrained Networks. Real-time monitoring of large numbers of people is becoming increasingly important for applications such as efficient service delivery and security against both common crime and terrorism. The use of human operators for such tasks is infeasible due to the large amount of data collected. Existing autonomous video surveillance systems are prone to high numbers of false alarms and often require expensive hardware. This proposal seeks to address both difficulties by using rigorous statistical signal processing methods to optimally fuse information from a network of low-cost cameras.Read moreRead less
Towards Distributed Phased Array Radar for High Resolution Weather Monitoring. Several recent reports on climate change by leading international and national bodies forecast that the rate of weather hazards such as storms and wind-shear, and of weather-associated phenomena such as bush fires will increase over the next 40 years. The current technology for monitoring weather events, and effects like wind-shift, which has a serious impact on dangers associated with bush fires, has significant wea ....Towards Distributed Phased Array Radar for High Resolution Weather Monitoring. Several recent reports on climate change by leading international and national bodies forecast that the rate of weather hazards such as storms and wind-shear, and of weather-associated phenomena such as bush fires will increase over the next 40 years. The current technology for monitoring weather events, and effects like wind-shift, which has a serious impact on dangers associated with bush fires, has significant weaknesses. We will deliver considerable improvements in monitoring capability by developing the technology for using a network of small phased array radars. We aim to place monitoring resources where end-user needs are greatest.Read moreRead less
Development of an Intelligent Perception System for Electric Brakes. Electric braking is a vital component of the drive by-wire systems whose development is currently being supported worldwide by many automobile manufacturers. The aim of this project is to contribute to the development of an efficient fully functional electrically operated braking system. The main focus is on development of the intelligent perceptual sensors required for optimum performance of a by-wire braking system (to be com ....Development of an Intelligent Perception System for Electric Brakes. Electric braking is a vital component of the drive by-wire systems whose development is currently being supported worldwide by many automobile manufacturers. The aim of this project is to contribute to the development of an efficient fully functional electrically operated braking system. The main focus is on development of the intelligent perceptual sensors required for optimum performance of a by-wire braking system (to be commercialised by 2007). This project will also facilitate the development of professional courses for by-wire technology. Such courses will play a crucial role in maintaining the competitiveness of the Australian car component industry as by-wire technology emerges.Read moreRead less