Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Transient Tissue ‘priming’ Via FAK Inhibition To Impair Pancreatic Cancer Progression And Improve Sensitivity To Gemcitabine/Abraxane
Funder
National Health and Medical Research Council
Funding Amount
$643,848.00
Summary
The success of cancer drugs is dependent on many factors including the properties of the tumour tissue. As a tumour grows it changes the tissue around it, and this affects response to treatment. Combining classical biology with engineering to generate 3D models that mimic tumours, along with cutting-edge imaging technology and mouse models, we will target FAK-controlled cancer cell pathways that sense tissue changes, together with already approved cancer drugs to improve patient outcome.
Therapeutic Targeting Of Cell Cycle Checkpoint Aberrations In Pancreatic Cancer: Personalised Medicine In Action
Funder
National Health and Medical Research Council
Funding Amount
$634,354.00
Summary
Less than 5% of people with pancreatic cancer (PC) survive 5 years, and the odds of patients beating this disease have remained unchanged for 50 years. Consequently, there is an urgent need to develop novel treatment approaches for this highly aggressive cancer. Our study aims to define novel therapeutic strategies for PC utilising specific anti-proliferative therapies and a personalised “companion biomarker” directed strategy.
Achieving Targeted Delivery Of Drugs To Uterine Muscle In Women For The Prevention Of Preterm Labour
Funder
National Health and Medical Research Council
Funding Amount
$469,008.00
Summary
We have patented liposomes targeted to the uterus, which enable us to deliver drugs specifically to the muscle cells of the uterus, increasing safety. The liposomes can be loaded with drugs that either block or promote contractions, creating a versatile drug delivery system that could treat premature labour or postpartum haemorrhage which are major clinical problems. We seek support to demonstrate their effectiveness in mouse and primate models of preterm labour prior to human studies.
Invasive fungal infections are a serious, escalating health issue. They cause severe disease with high death rates and are very costly to the health system. Current drugs often have suboptimal efficacy and cause side effects. New drugs are needed urgently. Many fungi, including the AIDS-related pathogen, Cryptococcus neoformans, secrete phospholipase B (Plbp) to facilitate infection. We will identify and investigate the Plbp secretion pathway as a novel anti-fungal drug target.
Discovery Early Career Researcher Award - Grant ID: DE230101422
Funder
Australian Research Council
Funding Amount
$467,132.00
Summary
Co-creating critical health literacy interventions. This project aims to enhance critical health literacy in culturally and linguistically diverse communities in western Sydney. Never in history has there been such an abundance of health information from numerous sources, with varying degrees of trustworthiness. This project intends to work with communities to co-create scalable interventions which promote critical health literacy and support people to navigate and appraise the sea of available ....Co-creating critical health literacy interventions. This project aims to enhance critical health literacy in culturally and linguistically diverse communities in western Sydney. Never in history has there been such an abundance of health information from numerous sources, with varying degrees of trustworthiness. This project intends to work with communities to co-create scalable interventions which promote critical health literacy and support people to navigate and appraise the sea of available health (mis)information. This project expects to provide significant social and health benefits through the development of innovative health literacy research methods for use with culturally-diverse communities and scalable interventions with the capacity to enhance critical skills across communities.Read moreRead less
Selling The Punt: An interdisciplinary analysis of the extent and impact of sports wagering marketing strategies in Australia. Sports wagering is the fastest growing segment of the gambling market in Australia. Despite widespread concern about the impact of marketing strategies on the risky consumption of wagering products by young men and adolescents, research and policy has failed to keep up with this rapidly growing industry. This study will provide: detailed information about the range of ma ....Selling The Punt: An interdisciplinary analysis of the extent and impact of sports wagering marketing strategies in Australia. Sports wagering is the fastest growing segment of the gambling market in Australia. Despite widespread concern about the impact of marketing strategies on the risky consumption of wagering products by young men and adolescents, research and policy has failed to keep up with this rapidly growing industry. This study will provide: detailed information about the range of marketing strategies used to sell sports wagering in Australia; important qualitative insights into the impact of these marketing strategies on gambling behaviours; and, recommendations for a comprehensive public health approach to help counter the potential long and short term risks associated with sports wagering marketing.Read moreRead less
Development of a comprehensive model and programmed intervention for emotion processing deficits in childhood-onset mental health problems. This research is in the National Research Priority, promoting and maintaining good health. Mental health problems cost Australia millions of dollars every year as well as creating immeasurable social adversity for individuals and families. The proposed research represents a significant step towards reducing these costs and improving the effectiveness of earl ....Development of a comprehensive model and programmed intervention for emotion processing deficits in childhood-onset mental health problems. This research is in the National Research Priority, promoting and maintaining good health. Mental health problems cost Australia millions of dollars every year as well as creating immeasurable social adversity for individuals and families. The proposed research represents a significant step towards reducing these costs and improving the effectiveness of early intervention and prevention. The research will lead to improvements in methods for early detection of child psychopathology with potential for implementation in both community health and educational services nation-wide. The research partnership will build Australia's capacity for innovative research in the development, early intervention and treatment of mental health problems.Read moreRead less
A study of contemporary family, social and cultural influences on first-time mothers' decisions about infant feeding and early parenting practices. Children who are never breastfed are more likely to experience respiratory infections, gastroenteritis, diabetes and as adults, high blood pressure, obesity and type-2 diabetes. This study of infant feeding decision-making in first-time mothers will inform strategies, grounded in the daily lives of women and families to assist mothers to breastfeed f ....A study of contemporary family, social and cultural influences on first-time mothers' decisions about infant feeding and early parenting practices. Children who are never breastfed are more likely to experience respiratory infections, gastroenteritis, diabetes and as adults, high blood pressure, obesity and type-2 diabetes. This study of infant feeding decision-making in first-time mothers will inform strategies, grounded in the daily lives of women and families to assist mothers to breastfeed for longer particularly in communities where breastfeeding is not the norm. Increased support for breastfeeding women from family, community and health professionals is likely to reduce the distress reported by many new mothers. Strategic application of findings will lead to health gains from increased breastfeeding and translate into significant cost savings for the Australian health system. Read moreRead less
Understanding and preventing mental health difficulties in young Australian men using the Internet. Mental health is a major public health problem in Australia. Young men are particularly vulnerable to suicide, drug and alcohol problems and yet fail to seek appropriate help. The Internet is currently accessed by 85% of Australia's youth and yet very little evidence exists which examines the capacity of the Internet to engage young men and promote help seeking. This project will build an evidence ....Understanding and preventing mental health difficulties in young Australian men using the Internet. Mental health is a major public health problem in Australia. Young men are particularly vulnerable to suicide, drug and alcohol problems and yet fail to seek appropriate help. The Internet is currently accessed by 85% of Australia's youth and yet very little evidence exists which examines the capacity of the Internet to engage young men and promote help seeking. This project will build an evidence base which explores how innovative on-line strategies and social marketing can effectively promote help seeking behaviour and improve mental health outcomes for young men. Read moreRead less