A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100041
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
A high-resolution isotope facility for low cost analysis of water, plant, and soil/sediment samples to understand environmental change. The most significant environmental challenges facing Australia include ensuring sustainable management of our water resources and conservation of both terrestrial and marine biodiversity, particularly in the face of our changing climate and land-use. The new instruments will accelerate progress across a number of projects aimed at understanding the developme ....A high-resolution isotope facility for low cost analysis of water, plant, and soil/sediment samples to understand environmental change. The most significant environmental challenges facing Australia include ensuring sustainable management of our water resources and conservation of both terrestrial and marine biodiversity, particularly in the face of our changing climate and land-use. The new instruments will accelerate progress across a number of projects aimed at understanding the development of groundwater resources, the relative dependency of ecosystems on groundwater versus soil and surface water, and an assessment of the likely impacts of altered hydrology, especially dewatering and salinisation, on ecosystems. In addition, they will also be used to extend our knowledge of climate variability in the recent past and increase understanding of critical marine resources.Read moreRead less