New mathematics for lipids and cells: structured models for atherosclerosis. The project aims to create new mathematical theory for immune cell behaviour which leads to heart attacks and strokes. This includes formulation and analysis of new types of mathematical models for atherosclerotic plaque development, leading to the creation of new mathematical tools to investigate cell fate in plaques and to generate new hypotheses for experimental research. Expected outcomes of this project include po ....New mathematics for lipids and cells: structured models for atherosclerosis. The project aims to create new mathematical theory for immune cell behaviour which leads to heart attacks and strokes. This includes formulation and analysis of new types of mathematical models for atherosclerotic plaque development, leading to the creation of new mathematical tools to investigate cell fate in plaques and to generate new hypotheses for experimental research. Expected outcomes of this project include powerful and reliable mathematical models ready for application, and national and international collaborations with scientists and mathematicians. This should provide significant benefits including increased capacity to use mathematical models in vascular biology and training young researchers in interdisciplinary methods.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100403
Funder
Australian Research Council
Funding Amount
$468,582.00
Summary
Defining how gut bacteria regulate metabolism: a role for gut serotonin. This project aims to understand how serotonin-producing cells in the gut interact with gut bacteria (the microbiome), using a combination of cells in culture and live germ-free and genetically modified mice. This project expects to generate new knowledge regarding cellular interactions that underlie important physiological pathways, such as the control of blood glucose and fat storage. The intended outcomes of this project ....Defining how gut bacteria regulate metabolism: a role for gut serotonin. This project aims to understand how serotonin-producing cells in the gut interact with gut bacteria (the microbiome), using a combination of cells in culture and live germ-free and genetically modified mice. This project expects to generate new knowledge regarding cellular interactions that underlie important physiological pathways, such as the control of blood glucose and fat storage. The intended outcomes of this project are to identify how gut bacteria communicate with serotonin-producing cells to regulate metabolism, and whether diet acts via a gut microbiome-serotonin axis to impact physiology. The expected benefit of this project will be to provide a new understanding of highly complex physiological systems that regulate our health.Read moreRead less