Optimising the spring in your step to enhance footwear design. This project aims to examine how the nervous system adjusts the mechanical function of our feet across a spectrum of speeds, from slow running through to maximal effort sprinting. The proposed research will explore how the nervous system controls the function of the foot to meet the ever-varying demands of locomotion in the real-world. Expected outcomes of this project are to determine if running shoes help or hinder the natural spri ....Optimising the spring in your step to enhance footwear design. This project aims to examine how the nervous system adjusts the mechanical function of our feet across a spectrum of speeds, from slow running through to maximal effort sprinting. The proposed research will explore how the nervous system controls the function of the foot to meet the ever-varying demands of locomotion in the real-world. Expected outcomes of this project are to determine if running shoes help or hinder the natural spring-like function of the foot. It will explain a conceptually novel design allowing shoes to support our feet, whilst harnessing the energetic benefits of the foot's spring-like function. This research has the potential to revolutionise athletic footwear design and has direct implications for enhanced performance in running athletes.Read moreRead less
Remodelling encapsulin nanocages to help enhance plant carbon fixation. Nature has evolved mechanisms in microbial systems to improve photosynthetic efficiency by saturating the enzyme Rubisco with carbon dioxide. These carbon concentrating mechanisms are genetically complex, precluding successful introduction into crops. Our simpler approach is to use encapsulins, a new source of robust bacterial pore-containing nanocages made from a single gene. This project will optimise the development of sy ....Remodelling encapsulin nanocages to help enhance plant carbon fixation. Nature has evolved mechanisms in microbial systems to improve photosynthetic efficiency by saturating the enzyme Rubisco with carbon dioxide. These carbon concentrating mechanisms are genetically complex, precluding successful introduction into crops. Our simpler approach is to use encapsulins, a new source of robust bacterial pore-containing nanocages made from a single gene. This project will optimise the development of synthetic encapsulin-Rubisco carbon-fixing nanoreactors and transform them into leaf chloroplasts to test their impact on plant photosynthesis and growth. Our genetically simpler solution will aid ongoing global efforts to deliver overdue step change improvements in agricultural productivity.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100068
Funder
Australian Research Council
Funding Amount
$931,950.00
Summary
Australian Advanced Metabolic Signal Discovery, and Imaging Platform. This proposal aims to establish an Australian Advanced Metabolic Signal Discovery and Imaging platform. The platform consists of an ultra-high resolution gas chromatography mass spectrometer and an imaging mass spectrometry upgrade for a second existing high resolution mass spectrometer. The facility will break barriers currently limiting discovery and localisation of metabolic changes during plant and animal development under ....Australian Advanced Metabolic Signal Discovery, and Imaging Platform. This proposal aims to establish an Australian Advanced Metabolic Signal Discovery and Imaging platform. The platform consists of an ultra-high resolution gas chromatography mass spectrometer and an imaging mass spectrometry upgrade for a second existing high resolution mass spectrometer. The facility will break barriers currently limiting discovery and localisation of metabolic changes during plant and animal development under environmental stress; integral chemical signals exchanged in host-microbe interactions; and volatile signatures linked to ecosystem health and developmental anomalies in animals. Results will inform innovative strategies to enhance biological adaptation, climate resilience and plant, animal, and ecosystem health.Read moreRead less
Understanding snow gum dieback for effective and integrated management. The project leverages recent research and infrastructure investments and our determined and collaborative team as it aims to: 1) assess the future geography of snow gum dieback in the high country and identify priority locations for pro-active management, 2) quantify the impact of snow gums on high country water and carbon budgets and thus the socio- economic and biodiversity values, and 3) determine options for mitigation. ....Understanding snow gum dieback for effective and integrated management. The project leverages recent research and infrastructure investments and our determined and collaborative team as it aims to: 1) assess the future geography of snow gum dieback in the high country and identify priority locations for pro-active management, 2) quantify the impact of snow gums on high country water and carbon budgets and thus the socio- economic and biodiversity values, and 3) determine options for mitigation. Dieback of our iconic snow gum forests is diminishing the ecological, hydrological and cultural values of the Australian Alps and will impact state and national water-supply and power-generation systems. Our research will inform Alps-wide management efforts designed for long-term success.Read moreRead less
Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This k ....Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This knowledge will reveal how IPO5 controls formation of sperm by revealing what other proteins it binds to and how this affects cell signaling and responses to the environment.
Benefits: This will provide information about potential interventions to control fertility or to repair abnormal cells.
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Resolving the role of dryland flooding in the global carbon cycle. Aquatic sources of carbon dioxide and methane are globally significant, but unknown for flooded drylands. The aim of this project is to use an innovative combination of well-integrated methodologies to determine if flooded drylands release large amounts of carbon dioxide and methane. This project is significant because this release of carbon dioxide and methane has not previously been accounted for and may change the magnitude of ....Resolving the role of dryland flooding in the global carbon cycle. Aquatic sources of carbon dioxide and methane are globally significant, but unknown for flooded drylands. The aim of this project is to use an innovative combination of well-integrated methodologies to determine if flooded drylands release large amounts of carbon dioxide and methane. This project is significant because this release of carbon dioxide and methane has not previously been accounted for and may change the magnitude of the global terrestrial carbon dioxide sink and account of some of the planet’s missing sources of methane. The outcomes of this project will make a significant contribution to our understanding of the global carbon cycle and earth climate system, and inform future management of these systems.
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Flipping the mattress: infinite polyurethane recycling by synthetic biology. Australia is covered in billions of tonnes of plastic and yet <10% is recycled today. Polyurethane (PU) is ubiquitous in our everyday lives, from lacquer coatings to elastane clothing to durable foam padding in car seats, cushions and mattresses. Currently, there are few avenues for PU recycling and much ends up in landfill e.g., a single mattress produces 15-20kg of PU foam waste. Luckily, biodegradation of PU can occu ....Flipping the mattress: infinite polyurethane recycling by synthetic biology. Australia is covered in billions of tonnes of plastic and yet <10% is recycled today. Polyurethane (PU) is ubiquitous in our everyday lives, from lacquer coatings to elastane clothing to durable foam padding in car seats, cushions and mattresses. Currently, there are few avenues for PU recycling and much ends up in landfill e.g., a single mattress produces 15-20kg of PU foam waste. Luckily, biodegradation of PU can occur naturally via various microbial means and from insects, like Galleria mellonella larvae. The overall aim of this research project is to understand plastic biodegradation and translate nature’s solutions into flexible and efficient synthetic enzyme technologies that can sustainably recycle commonly used PU foams. Read moreRead less
Forecasting live fuel moisture content, the on/off switch for forest fire. Dry forest fuels are a precursor of large bushfires. This research aims to develop, for the first time, a model to reliably forecast the moisture content of live fuels (e.g. the foliage and fine branches of shrubs and trees). This will be achieved by combining (i) satellite-derived estimates of live fuel moisture content, (ii) forecasts of soil moisture, and (iii) plant physiological responses to soil dryness. Forecasts o ....Forecasting live fuel moisture content, the on/off switch for forest fire. Dry forest fuels are a precursor of large bushfires. This research aims to develop, for the first time, a model to reliably forecast the moisture content of live fuels (e.g. the foliage and fine branches of shrubs and trees). This will be achieved by combining (i) satellite-derived estimates of live fuel moisture content, (ii) forecasts of soil moisture, and (iii) plant physiological responses to soil dryness. Forecasts of live fuel moisture content will deliver an early warning system of the risk of bushfires. These forecasts will also facilitate improved planning of prescribed burns: if fuels are too dry there is a risk of burns escaping, conversely, if fuels are too wet there is a risk that burns will fail to meet objectives.Read moreRead less
Ecosystem resilience of Shark Bay under changing ocean climate. This project aims to investigate the resilience of the Shark Bay World Heritage Site to projected climate change. This project will generate new knowledge for marine conservation through analyses of habitat loss on nutrient budgets and productivity in seagrass and microbialite ecosystems. Expected outcomes are an improved understanding of climate-driven shifts on ecosystem processes in Shark Bay, incorporating science-based evidence ....Ecosystem resilience of Shark Bay under changing ocean climate. This project aims to investigate the resilience of the Shark Bay World Heritage Site to projected climate change. This project will generate new knowledge for marine conservation through analyses of habitat loss on nutrient budgets and productivity in seagrass and microbialite ecosystems. Expected outcomes are an improved understanding of climate-driven shifts on ecosystem processes in Shark Bay, incorporating science-based evidence for better conservation and management. This will provide significant benefits by contributing to the future-proofing of Shark Bay’s World Heritage values to climate change, and more broadly by demonstrating the consequences of the continued tropicalisation of Australia’s coastline.Read moreRead less