Artificial photosynthesis: developing a simple, functional light harvesting porphyrin-protein ensemble. Inspired by photosynthesis, in this project we will fabricate a light driven reaction centre using an array of artificial chlorophylls or porphyrins integrated into a synthetic protein. This centre has the potential to be used as a photocatalyst to, for example, split water into hydrogen and oxygen or be the active component of a solar cell.
The Protein Corona: Imaging the nanoparticle biological identity card. The project will determine how the intrinsic physico-chemical properties of nanoparticles translate into extrinsic biological properties through their interaction with physiological proteins in the body. This process is complex and poorly understood due to our inability to visualise it through standard imaging techniques. The project aims to develop a new tool to visualise, study, quantify and design the protein ‘corona’. The ....The Protein Corona: Imaging the nanoparticle biological identity card. The project will determine how the intrinsic physico-chemical properties of nanoparticles translate into extrinsic biological properties through their interaction with physiological proteins in the body. This process is complex and poorly understood due to our inability to visualise it through standard imaging techniques. The project aims to develop a new tool to visualise, study, quantify and design the protein ‘corona’. These are the adsorbed protein layers that are rapidly formed in contact with biological liquids which allow cells to recognise and process nanoparticles. The proteins are dependent on factors such as size, shape, surface chemistry and biological history of the particles. Being able to ‘read’ and ‘write’ the protein corona would enable efficient cellular targeting of pharmaceutical drugs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100146
Funder
Australian Research Council
Funding Amount
$860,000.00
Summary
Pulsed Electron Paramagnetic Resonance: an enhanced capability for research in quantum physics, materials science, chemistry and biological sciences. By improving our ability to investigating materials which impact fields ranging from disease and ageing to renewable energy and quantum information, the pulsed electron paramagnetic resonance spectrometer provided will allow the project to address some of the fundamental questions facing society.
Understanding sub-cellular systems at the atomic level. By extending the range of biomolecular systems that can be modelled computationally at the atomic level the project will enable important biomedical processes such as how bacterial toxins penetrate cell membranes and how protein hormones transmit signals into cells to be understood in unprecedented detail.
ARC Centre of Excellence in Advanced Molecular Imaging. The Centre of Excellence in Advanced Molecular Imaging will innovatively integrate physics, chemistry and biology to unravel the complex molecular interactions that define immunity. The Centre will develop new imaging methods to visualize atomic, molecular and cellular details of how immune proteins interact and
effect immune responses. Outcomes: (i) new technological innovations leading to new imaging methods and products; and (ii) fundame ....ARC Centre of Excellence in Advanced Molecular Imaging. The Centre of Excellence in Advanced Molecular Imaging will innovatively integrate physics, chemistry and biology to unravel the complex molecular interactions that define immunity. The Centre will develop new imaging methods to visualize atomic, molecular and cellular details of how immune proteins interact and
effect immune responses. Outcomes: (i) new technological innovations leading to new imaging methods and products; and (ii) fundamental advances in understanding details of immune responses in health and disease. The Centre will enable Australia to be an international leader in biological imaging, to train next
generation interdisciplinary scientists, and to provide new insights for combating common diseases that afflict society.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100174
Funder
Australian Research Council
Funding Amount
$800,000.00
Summary
Innovative synchrotron science - program for access to the Australian National Beamline Facility and cutting-edge beamlines at international synchrotrons. Synchrotron science dramatically affects the community through the innovative scientific, engineering and medical research outcomes it produces. This program for access to synchrotron beamlines is aimed at enhancing Australia's high international standing in synchrotron science and will have many flow-on effects in areas such as health and ind ....Innovative synchrotron science - program for access to the Australian National Beamline Facility and cutting-edge beamlines at international synchrotrons. Synchrotron science dramatically affects the community through the innovative scientific, engineering and medical research outcomes it produces. This program for access to synchrotron beamlines is aimed at enhancing Australia's high international standing in synchrotron science and will have many flow-on effects in areas such as health and industry.Read moreRead less