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HIV infection continues to be a global problem, an effective vaccine is critical to halting its spread. For those infected there is no cure. They require life-long, expensive therapy. The proposed research looks to provide insights that will contribute to the development of an effective vaccine and to clearing the virus from infected patients by using cutting edge laboratory techniques to study patients in populations that are pathogenically informative.
Modulation Of Cytokine Responses To Improve Transplant Outcome.
Funder
National Health and Medical Research Council
Funding Amount
$26,186.00
Summary
Bone marrow transplantation remains a mainstay of curative therapy for haematological malignancies. This curative effect is mediated by the transplanted donor immune system which rejects the recipient malignancy. However, the procedure is limited by its serious side effect, known as graft-versus-host disease. This application seeks to better understand these two processes at both an immunological and clinical level with the aim of separating the two so that more patients may be cured of leukaemi ....Bone marrow transplantation remains a mainstay of curative therapy for haematological malignancies. This curative effect is mediated by the transplanted donor immune system which rejects the recipient malignancy. However, the procedure is limited by its serious side effect, known as graft-versus-host disease. This application seeks to better understand these two processes at both an immunological and clinical level with the aim of separating the two so that more patients may be cured of leukaemia.Read moreRead less
Immunopathogenesis And Manipulation Of The HIV Reservoir
Funder
National Health and Medical Research Council
Funding Amount
$494,732.00
Summary
Kelleher is a Clinical immunologist with a globally recognised, sustained track record of translational research which has impacted both on our understanding of HIV immunopathogenesis and on the way HIV infection is treated. He will conduct a series of studies that encompass basic scientific techniques through to pivotal pre-clinical and clinical studies that will provide a pathway towards control of HIV-infection without daily therapy.
Professor Stick is a career clinician researcher in Paediatric Respiratory Medicine. He has established worl-leading research teams focused on respiratory diseases in young children such as cystic fibrosis and asthma. He has has developed innovative methods to study early childhood respiratory diseases and has been responsible for training scores of clinicians and scientists in the field. He has received national and international awards in recognition of his achievements.