Dissecting the physiology of multipotent mesenchymal stromal cells to develop vaccine candidates for respiratory disease. The project aims to gain an understanding of how a type of adult stem cell inhibits immune responses that cause asthma. The project will produce new stem cell products and facilitate the design of a vaccine for asthma and other respiratory diseases, which would greatly reduce the burden of such conditions.
A coupled finite volume method for viscoelastic flow problems on highly-skewed unstructured meshes: a computational rheology revolution. Commercial tools are unavailable for 21st century industry to analyse complex flow processes involving viscoelastic materials. Using fabrication of microstructured polymer optical fibre as a key case study, a coupled finite volume methodology holds the key for the next generation of computational rheology simulators.
Cause and effect: new mechanisms of particles formation in thunderstorms. This project aims to identify meaningful and specific indicators for predicting particle formation and alteration during thunderstorms. How thunderstorms develop is well-understood. However, identifying meaningful and specific indicators for predicting particle alteration during a thunderstorm is still not clear. This project will practically contribute to the evidence of the impact of air particulates, thereby having dire ....Cause and effect: new mechanisms of particles formation in thunderstorms. This project aims to identify meaningful and specific indicators for predicting particle formation and alteration during thunderstorms. How thunderstorms develop is well-understood. However, identifying meaningful and specific indicators for predicting particle alteration during a thunderstorm is still not clear. This project will practically contribute to the evidence of the impact of air particulates, thereby having direct implications for meteorological, and air pollution policy in Australia and worldwide. This project will allow researchers to understand the impact of these factors on the escalation of the causative effects, and to find a way to prevent unnecessary fatal outcomes.Read moreRead less
Inerter-enhanced metastructure for structural vibration control. Meta-based technique has been proposed for vibration control recently due to its special wave filtering effect. However, the current techniques are difficult to attenuate low-frequency waves, thus not suitable for civil structural vibration control. This project proposes incorporating an inerter-based element into the unit cell of a metastructure. Due to the unique mass amplification characteristic of inerter element, manipulating ....Inerter-enhanced metastructure for structural vibration control. Meta-based technique has been proposed for vibration control recently due to its special wave filtering effect. However, the current techniques are difficult to attenuate low-frequency waves, thus not suitable for civil structural vibration control. This project proposes incorporating an inerter-based element into the unit cell of a metastructure. Due to the unique mass amplification characteristic of inerter element, manipulating low-frequency waves becomes possible. Practical designs are developed and applied to control the adverse vibrations of engineering structures induced by three typical vibration sources. Comprehensive analytical, experimental and numerical studies are carried out to examine the effectiveness of the proposed method.Read moreRead less
High performance electromagnetic airborne mineral exploration for discovery of deep earth resources. Airborne mineral exploration underpins Australia’s mining industry. Sensing systems are particularly effective for discovering nickel ore and water bodies but salty soil often blocks signals. This project uses a patented breakthrough in vibration isolation to create instruments able to detect minerals 50 per cent to 100 per cent deeper than normal.
The control of chromosome division during female meiosis. Mammalian eggs are stored life-long and finally mature in the hours before ovulation. This project examines how the chromosomes in the egg are separated properly so as to produce a mature egg capable of being fertilized by a sperm. Often in eggs chromosome division is imprecisely executed, and this project will help us understand why this occurs.
Flow structures and transport: predictability and control. Moving flow structures (the boundary of an eddy, the flow interface between two fluids) are crucial in fluid mixing and in the transport of heat, pollutants and nutrients. This project will analyse their roles in improving predictions of spreading extents and rates for geophysical-scale problems, and in controlling transport at the micro-scale. Inaccuracies in currently available numerical diagnostics for transport prediction will be com ....Flow structures and transport: predictability and control. Moving flow structures (the boundary of an eddy, the flow interface between two fluids) are crucial in fluid mixing and in the transport of heat, pollutants and nutrients. This project will analyse their roles in improving predictions of spreading extents and rates for geophysical-scale problems, and in controlling transport at the micro-scale. Inaccuracies in currently available numerical diagnostics for transport prediction will be comprehensively evaluated via comparison with recent exact models. Analytical methods for quantifying transport under unsteady flow protocols will be developed, and used to answer questions on controlling transport in microfluidic applications in conjunction with experimentalists.Read moreRead less
Non-contact Integrity Assessment of Façade Panels of High-rise Buildings. Disintegration of the external façade (with tiles, plates, etc.) of high-rise buildings presents a great challenge and a threat to community. This project develops fundamental knowledge and algorithms that underpin the deployment of a new technique for fast and automated quantitative integrity assessment of façade units of high-rise buildings, integrating mechanisms of directional acoustic waves, vibro-acoustics of façade ....Non-contact Integrity Assessment of Façade Panels of High-rise Buildings. Disintegration of the external façade (with tiles, plates, etc.) of high-rise buildings presents a great challenge and a threat to community. This project develops fundamental knowledge and algorithms that underpin the deployment of a new technique for fast and automated quantitative integrity assessment of façade units of high-rise buildings, integrating mechanisms of directional acoustic waves, vibro-acoustics of façade tiles or panels, laser sensing technology, deep learning algorithms and drone technology. Outcomes of this project are critical for implementing the new technology for enhanced safety to community and the development of new procedures for driving down maintenance costs of the external façade of high-rise buildings.Read moreRead less
Decoding the spatiotemporal control of DNA replication and repair. DNA replication is the fundamental mechanism of genetic inheritance and essential for all cellular life. This project aims to inform our understanding of how human cells coordinate the DNA replication machinery in time and space to accurately copy the human genome. By applying multiple innovative approaches and employing an interdisciplinary research team, this project is anticipated to generate new knowledge that explains how th ....Decoding the spatiotemporal control of DNA replication and repair. DNA replication is the fundamental mechanism of genetic inheritance and essential for all cellular life. This project aims to inform our understanding of how human cells coordinate the DNA replication machinery in time and space to accurately copy the human genome. By applying multiple innovative approaches and employing an interdisciplinary research team, this project is anticipated to generate new knowledge that explains how the human genome is replicated. This knowledge is expected to generate research publications of high quality and provide economic benefits, such as unlocking new potentially patentable DNA technologies. Read moreRead less
Single molecule intracellular intravital imaging of actin dynamics. The project intends to develop imaging technology to visualise fundamental processes in cells within a living animal. The focus will be on the actin cytoskeleton, a dynamic macromolecular machine involved in key cellular processes including cell structure, mobility and division. It is exquisitely sensitive to environmental perturbations, requiring it to be studied in cells in living tissue. The project aims to extend the resolut ....Single molecule intracellular intravital imaging of actin dynamics. The project intends to develop imaging technology to visualise fundamental processes in cells within a living animal. The focus will be on the actin cytoskeleton, a dynamic macromolecular machine involved in key cellular processes including cell structure, mobility and division. It is exquisitely sensitive to environmental perturbations, requiring it to be studied in cells in living tissue. The project aims to extend the resolution of live imaging to the single molecule to understand the dynamics of actin assembly with implications for cellular processes that are hijacked in diseases. It also aims to provide a novel assay that may enable testing of the impact of drugs on cellular processes in real time.Read moreRead less