Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge mic ....Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge microscopy techniques to visualise whether the endogenous astrocyte protein metallothionein can promote regeneration in the injured nervous system of living zebrafish. The successful outcomes of this project will provide significant insight into understanding how the brain responds to injury.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100040
Funder
Australian Research Council
Funding Amount
$580,000.00
Summary
Fast Disk Storage to Enable Big Data Science in Weather, Oceans and Climate. This project aims to expand Australia's capacity to do high-impact innovative climate, weather and oceanographic science. Science of this kind relies on massive data coupled to computationally highly intensive and complex analysis. Therefore, the project will purchase fast disk storage and install it at the National Computing Infrastructure. It is anticipated that the project will benefit the nation through better under ....Fast Disk Storage to Enable Big Data Science in Weather, Oceans and Climate. This project aims to expand Australia's capacity to do high-impact innovative climate, weather and oceanographic science. Science of this kind relies on massive data coupled to computationally highly intensive and complex analysis. Therefore, the project will purchase fast disk storage and install it at the National Computing Infrastructure. It is anticipated that the project will benefit the nation through better understanding of the climate system, including extremes; improvements in our capacity to make predictions; and through applications of the science to forecasting, the management of resources among other many other things.Read moreRead less
Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-th ....Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-thalassaemia, understanding the specific aHb-binding factor, AHSP is a goal of national significance. In the long term, manipulation of AHSP function through gene therapy may have a direct role in the treatment of thalassaemia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100048
Funder
Australian Research Council
Funding Amount
$630,000.00
Summary
Atmospheric integrated research on burdens and oxidative capacity. Atmospheric integrated research on burdens and oxidative capacity: No single player in the Australian research community can make a large suite of atmospheric composition measurements, while the combined capability of the community is tremendous. Providing a platform to bring this capability together is cost effective and is expected to provide strong scientific return. This defines the requirements for Atmospheric Integrated Res ....Atmospheric integrated research on burdens and oxidative capacity. Atmospheric integrated research on burdens and oxidative capacity: No single player in the Australian research community can make a large suite of atmospheric composition measurements, while the combined capability of the community is tremendous. Providing a platform to bring this capability together is cost effective and is expected to provide strong scientific return. This defines the requirements for Atmospheric Integrated Research on Burdens and Oxidative capacity (AIR-BOX) to make a valuable contribution to Australian Atmospheric Science research. This project aims to provide a suite of mobile equipment including a chemical ionisation mass spectrometer, an ultraviolet-visible radiation spectrometer, a mini micropulse lidar, an in situ Fourier transform infrared spectrometer, and a cloud condensation nuclei counter. It will be capable of remote and autonomous deployment, real-time data transfer and control, a wide range of tracer measurements, flexible configuration, and physical as well as tracer measurements.Read moreRead less
ARC Centres of Excellence for Climate System Science. Our capacity to assess the threat of climate change is undermined by an unacceptable level of uncertainty in the understanding and modelling of regional climates. The Centre will undertake world-class research targeting identified weaknesses in the physical, chemical and biological components of the climate system. We will engage and nurture graduate students and postdoctoral follows through a program of graduate training and mentoring to per ....ARC Centres of Excellence for Climate System Science. Our capacity to assess the threat of climate change is undermined by an unacceptable level of uncertainty in the understanding and modelling of regional climates. The Centre will undertake world-class research targeting identified weaknesses in the physical, chemical and biological components of the climate system. We will engage and nurture graduate students and postdoctoral follows through a program of graduate training and mentoring to permanently transform our understanding of climate systems science particularly for the Australian region. The key outcome will be a dramatic enhancement in national capacity to understand and project the scale of future regional climate change.Read moreRead less
Understanding spread in sea level rise projections. This project aims to investigate changes in water properties and ocean circulation mechanisms leading to intermodel spread in sea-level projections. Sea-level rise projections for this 21st century largely disagree in magnitude and spatial changes between climate models, particularly in hotspots. The expected outcomes will contribute towards more rigorous constraints on the likelihood of future warming and sea-level rise projections, and are al ....Understanding spread in sea level rise projections. This project aims to investigate changes in water properties and ocean circulation mechanisms leading to intermodel spread in sea-level projections. Sea-level rise projections for this 21st century largely disagree in magnitude and spatial changes between climate models, particularly in hotspots. The expected outcomes will contribute towards more rigorous constraints on the likelihood of future warming and sea-level rise projections, and are aligned with scientific deliverables required to address key questions in support of Australia’s climate change policy. They are also aligned with international scientific deliverables in support of the World Climate Research Programme Grand Challenge on Regional Sea Level Change and Coastal Impacts.Read moreRead less
Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to th ....Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or neurodegenerative disease. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest biochemical and cellular processes associated with aging or disease of the brain.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100075
Funder
Australian Research Council
Funding Amount
$315,000.00
Summary
Acoustic liquid handling robotics for bioactive compound discovery. This project aims to use a Labcyte Echo 550 acoustic dispenser with Combination Software to deliver sophisticated assay-ready screening. The Echo is the only liquid handling dispenser for 1536-well microplates and will allow Australian researchers to develop assay miniaturisation. The robotics will provide our nation’s researchers with a distinct competitive edge by enhancing assay sophistication, accuracy and reproducibility wh ....Acoustic liquid handling robotics for bioactive compound discovery. This project aims to use a Labcyte Echo 550 acoustic dispenser with Combination Software to deliver sophisticated assay-ready screening. The Echo is the only liquid handling dispenser for 1536-well microplates and will allow Australian researchers to develop assay miniaturisation. The robotics will provide our nation’s researchers with a distinct competitive edge by enhancing assay sophistication, accuracy and reproducibility while reducing cost. The expected benefits will advance the elucidation of molecular mechanisms involved in complex biological phenomena. The benefits of this are substantial, including reduction in test compound and reagents, which in turn reduces laboratory costs, conserves cells and increases data quality.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100043
Funder
Australian Research Council
Funding Amount
$389,000.00
Summary
Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies. This project aims to undertake fast probe-free biochemical/chemical imaging of heterogeneity within cells and materials surfaces with new infrared and Raman imaging. It will generate new fundamental knowledge on: cell heterogeneity and dynamic processes; technologies for optimising cell printing; understanding toxicity of microplastics; and protocols for measuring materials of technological relevance. Expected outcomes inc ....Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies. This project aims to undertake fast probe-free biochemical/chemical imaging of heterogeneity within cells and materials surfaces with new infrared and Raman imaging. It will generate new fundamental knowledge on: cell heterogeneity and dynamic processes; technologies for optimising cell printing; understanding toxicity of microplastics; and protocols for measuring materials of technological relevance. Expected outcomes include: interdisciplinary collaborations in new protocols for in-vitro drug development; cell printing technologies; environmental impacts of microplastics; and materials design. Expected benefits include innovative approaches to early stage drug design; improved environmental controls and advances in innovative materials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100107
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Purchase of a multi-purpose Schottky field emission gun scanning electron microscope. Scanning electron microscopy is a basic analytical tool for imaging surfaces of natural and synthetic materials and identification of nanometre-scale features and their compositions. At the University of Tasmania, it supports four of our six designated priority research themes: Antarctic and Marine Studies, Environment, Frontier Technologies, and Sustainable Primary Production. Our research depending on this te ....Purchase of a multi-purpose Schottky field emission gun scanning electron microscope. Scanning electron microscopy is a basic analytical tool for imaging surfaces of natural and synthetic materials and identification of nanometre-scale features and their compositions. At the University of Tasmania, it supports four of our six designated priority research themes: Antarctic and Marine Studies, Environment, Frontier Technologies, and Sustainable Primary Production. Our research depending on this technique includes many fundamental and applied topics from a wide range of disciplines, such as developing portable detection devices for explosives, finding more efficient and sustainable ways to explore for ore, investigating the effects of climate change on marine ecosystems and improving salinity and drought tolerance of crops.Read moreRead less