Southern Ocean aerosols: sources, sinks and impact on cloud properties. This project aims to provide fundamental process-level understanding of atmospheric aerosol processes over the Southern Ocean, a region that has a profound influence on the Australian and global climate and where climate models perform poorly. Comprehensive observations during 3 Southern Ocean voyages and land-based measurements will enhance our knowledge of aerosols and cloud formation in that region and provide much-needed ....Southern Ocean aerosols: sources, sinks and impact on cloud properties. This project aims to provide fundamental process-level understanding of atmospheric aerosol processes over the Southern Ocean, a region that has a profound influence on the Australian and global climate and where climate models perform poorly. Comprehensive observations during 3 Southern Ocean voyages and land-based measurements will enhance our knowledge of aerosols and cloud formation in that region and provide much-needed data for improving global climate models. Expected outcomes include more accurate seasonal and latitudinal representations of Southern Ocean aerosol populations, properties and sources. The main benefit includes improvements in weather forecasting and future climate projection for Australia and the Southern Hemisphere.Read moreRead less
Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge mic ....Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge microscopy techniques to visualise whether the endogenous astrocyte protein metallothionein can promote regeneration in the injured nervous system of living zebrafish. The successful outcomes of this project will provide significant insight into understanding how the brain responds to injury.Read moreRead less
Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-th ....Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-thalassaemia, understanding the specific aHb-binding factor, AHSP is a goal of national significance. In the long term, manipulation of AHSP function through gene therapy may have a direct role in the treatment of thalassaemia.Read moreRead less
Understanding spread in sea level rise projections. This project aims to investigate changes in water properties and ocean circulation mechanisms leading to intermodel spread in sea-level projections. Sea-level rise projections for this 21st century largely disagree in magnitude and spatial changes between climate models, particularly in hotspots. The expected outcomes will contribute towards more rigorous constraints on the likelihood of future warming and sea-level rise projections, and are al ....Understanding spread in sea level rise projections. This project aims to investigate changes in water properties and ocean circulation mechanisms leading to intermodel spread in sea-level projections. Sea-level rise projections for this 21st century largely disagree in magnitude and spatial changes between climate models, particularly in hotspots. The expected outcomes will contribute towards more rigorous constraints on the likelihood of future warming and sea-level rise projections, and are aligned with scientific deliverables required to address key questions in support of Australia’s climate change policy. They are also aligned with international scientific deliverables in support of the World Climate Research Programme Grand Challenge on Regional Sea Level Change and Coastal Impacts.Read moreRead less
Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to th ....Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or neurodegenerative disease. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest biochemical and cellular processes associated with aging or disease of the brain.Read moreRead less
Southern Ocean Sea Ice – what happened and what happens next? This project will adress our lack of confidence in future projections of sea ice around Antarctica by elucidating the mechanisms controlling sea ice in the Southern Ocean.
There is low confidence is current sea ice projections, limiting our ability to predict ice shelf melt and sea level rise.
This project will lead to a detailed understanding of the future of sea ice in the Southern Ocean, improving our understanding of ocean dynam ....Southern Ocean Sea Ice – what happened and what happens next? This project will adress our lack of confidence in future projections of sea ice around Antarctica by elucidating the mechanisms controlling sea ice in the Southern Ocean.
There is low confidence is current sea ice projections, limiting our ability to predict ice shelf melt and sea level rise.
This project will lead to a detailed understanding of the future of sea ice in the Southern Ocean, improving our understanding of ocean dynamics, ice shelf melt, and sea level rise.
The results from this project will enhance projections of sea ice, and therefore also ice shelf melt and sea level rise. Improved sea level projections will aid policy decisions for coastal communities.Read moreRead less
Australia's variable rainfall - how dry or wet can it really get? Australia’s rainfall is extremely variable, which means existing weather records are too short to calculate the true risk posed by droughts and floods. This project aims to quantify how naturally variable the rainfall coming from the Indo-Pacific mid-latitudes is, allowing recent rainfall extremes and future projections to be assessed in a long-term context. This project expects to produce new estimates of atmospheric moisture bud ....Australia's variable rainfall - how dry or wet can it really get? Australia’s rainfall is extremely variable, which means existing weather records are too short to calculate the true risk posed by droughts and floods. This project aims to quantify how naturally variable the rainfall coming from the Indo-Pacific mid-latitudes is, allowing recent rainfall extremes and future projections to be assessed in a long-term context. This project expects to produce new estimates of atmospheric moisture budgets between Australia and Antarctica based on a novel, 1000-year length reconstruction of moisture-bearing southern Indian Ocean storms. This new information is critically needed by water managers so that they can properly calculate (and ultimately prepare for) the worst of Australia’s rainfall-related risks.Read moreRead less