Protecting Against Malaria Through Liver-resident Memory T Cells
Funder
National Health and Medical Research Council
Funding Amount
$1,196,853.00
Summary
We have shown that formation of liver-resident memory T cells (Trm), a newly discovered type of immune cells, can be induced by an innovative vaccination strategy called prime and trap for highly efficient protection against malaria in mice. Here, we will enhance prime and trap vaccination efficacy by defining the conditions that maximize liver Trm-mediated protection and will characterize simian and human liver Trm cells, paving the way to create the most efficient human malaria vaccine to date
Development And Validation Of A Latent Tuberculosis Diagnostic
Funder
National Health and Medical Research Council
Funding Amount
$534,865.00
Summary
Globally, tuberculosis is a leading cause of death with 9.6 million new diagnoses in 2014. The diagnosis of latent TB infection is important, but is difficult to make because current assays are suboptimal. We have developed a very simple assay which detects responses to TB antigens by co-expression of two surface markers expressed by CD4+ T cells. We propose to develop this into a highly standardised kit for the diagnosis of TB with our commercial partner Cytognos.
Initial Interactions Of Herpes Simplex Virus With Innate Immune Cells In Human Skin
Funder
National Health and Medical Research Council
Funding Amount
$522,589.00
Summary
Herpes simplex viruses 1 and 2 cause widespread and occasionally serious diseases including genital herpes, neonatal death and encephalitis. Current vaccine candidates are at best partially effective. This grant will examine the way that the virus enters, initially spreads within the skin and interacts with immune cells to help determine which cells should be stimulated by vaccines.
Discovery Early Career Researcher Award - Grant ID: DE120102645
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The cause of the poleward shift of Earth's storm tracks and jet streams. Why do global climate models shift the atmospheric storm tracks and jet streams poleward in simulations of future climate? This project will determine the underlying causes of the most important circulation change that is projected to occur with increasing greenhouse gases, and will allow much more accurate regional climate projections.
Local climate changes caused by large bushfire burnt areas. This project aims to quantify the impact on local climate produced by large burnt areas after extreme bushfires. This project expects to generate new knowledge on these previously unexplored fire-scar induced changes to local climate. It will extend an innovative approach that combines satellite based earth observation with very high resolution regional climate modelling to quantify the impacts on land-atmosphere feedbacks and local cli ....Local climate changes caused by large bushfire burnt areas. This project aims to quantify the impact on local climate produced by large burnt areas after extreme bushfires. This project expects to generate new knowledge on these previously unexplored fire-scar induced changes to local climate. It will extend an innovative approach that combines satellite based earth observation with very high resolution regional climate modelling to quantify the impacts on land-atmosphere feedbacks and local climate. Expected outcomes of this project include enhanced methods to quantify local climate changes after extreme fires and their effect on vegetation recovery. This should provide significant benefits to the planning for, and management of, vegetation recovery after extreme fires.Read moreRead less
Role of modulating water wave groups in enhancing air-water fluxes. This project aims to investigate the importance of the group structure and breaking of wind-generated waves of various scales in the air-water exchange of mass, momentum and energy. This project expects to generate new understanding in the area of air-water exchanges using an innovative approach based on direct numerical simulation of wind over unsteady water wave groups for a wide range of wind speed and wave steepness conditi ....Role of modulating water wave groups in enhancing air-water fluxes. This project aims to investigate the importance of the group structure and breaking of wind-generated waves of various scales in the air-water exchange of mass, momentum and energy. This project expects to generate new understanding in the area of air-water exchanges using an innovative approach based on direct numerical simulation of wind over unsteady water wave groups for a wide range of wind speed and wave steepness conditions.
Expected outcomes of this project include generating fundamental knowledge of the unresolved physics and new parameterisations for air-water exchange rates. This will deliver more accurate and more comprehensive forecast models for weather, inland and ocean waterways, and numerous industrial processes.Read moreRead less
The dynamics of turbulent entrainment in sheared convective boundary layers. This project aims to develop general laws to enable the accurate prediction of boundary layer entrainment processes. This will be significant in a wide range of environmental and engineering applications. In particular, the current lack of understanding of this area is a major source of uncertainty in the latest generation of global climate models.
Understanding extreme wind gusts and associated risks in NSW. Wind gusts are rare bursts of high wind, often associated with thunderstorm outflows. They can do significant structural damage, and their rarity and small scale make prediction and risk assessment difficult. This proposal seeks to better understand and predict wind gusts and their impacts to aid in planning. The project aims to use past observations, modelling, and basic theory to show what conditions lead to wind gusts and how like ....Understanding extreme wind gusts and associated risks in NSW. Wind gusts are rare bursts of high wind, often associated with thunderstorm outflows. They can do significant structural damage, and their rarity and small scale make prediction and risk assessment difficult. This proposal seeks to better understand and predict wind gusts and their impacts to aid in planning. The project aims to use past observations, modelling, and basic theory to show what conditions lead to wind gusts and how likely they are to exceed key thresholds. It targets important scientific and practical issues such as the joint occurrence of gusts and high rainfall, role of gusts in contributing to dust and other airborne pollutants, impacts of gusts on subsequent storm activity, and gusts in a warming climate.Read moreRead less
Novel techniques for interpreting atmospheric variability and its drivers. This project aims to improve the understanding of the causes of variability in atmospheric greenhouse gases, leading to better knowledge of how such processes will evolve in a changing climate. The project expects to use new measurement techniques to gain information about the spatial and temporal variability of atmospheric greenhouse gases. With the use of regional and global scale models, the measurements will be used t ....Novel techniques for interpreting atmospheric variability and its drivers. This project aims to improve the understanding of the causes of variability in atmospheric greenhouse gases, leading to better knowledge of how such processes will evolve in a changing climate. The project expects to use new measurement techniques to gain information about the spatial and temporal variability of atmospheric greenhouse gases. With the use of regional and global scale models, the measurements will be used to understand greenhouse gas fluxes and provide independent verification of current estimates. Expected outcomes include improved methods for verifying greenhouse gas emissions, which will contribute to improved emissions inventories and accounting promised under international agreements.Read moreRead less
Atmospheric Photothermal Oxidation as a New Reaction in the Atmosphere. Atmospheric models provide crucial advice on the current and future impacts of human activity on the atmosphere. This project hypothesizes the presence of a new class of chemical reactions that are unknown in atmospheric science and therefore missing from the best existing models. The reactions require both sunlight and air, and they behave differently to all other types of atmospheric reactions. This project aims to charact ....Atmospheric Photothermal Oxidation as a New Reaction in the Atmosphere. Atmospheric models provide crucial advice on the current and future impacts of human activity on the atmosphere. This project hypothesizes the presence of a new class of chemical reactions that are unknown in atmospheric science and therefore missing from the best existing models. The reactions require both sunlight and air, and they behave differently to all other types of atmospheric reactions. This project aims to characterise these reactions in the lab, understand them with theory, and quantify their global impact through modelling. Expected benefits include new understanding of atmospheric chemistry, more accurate model predictions, and—as a result—better strategies for managing the impacts of human activity on the environment.Read moreRead less