Investigating Wnt signaling during human nephron commitment and patterning. Aims: To use gene edited stem cell lines that display cell location, identity and cell state to map human kidney tissue formation in the laboratory. By monitoring how each cell responds to those around it across time and space, we will for the first time map the formation of kidney tissue in the dish.
Significance: Understanding how stem cells form a tissue will help us to improve and control the process. This is key to ....Investigating Wnt signaling during human nephron commitment and patterning. Aims: To use gene edited stem cell lines that display cell location, identity and cell state to map human kidney tissue formation in the laboratory. By monitoring how each cell responds to those around it across time and space, we will for the first time map the formation of kidney tissue in the dish.
Significance: Understanding how stem cells form a tissue will help us to improve and control the process. This is key to advancing tissue engineering.
Expected outcomes: The proposal will pioneer state-of-the-art imaging, gene editing and machine learning approaches, generating models of human development that are currently unavailable.
Benefits: This understanding will guide the development of novel approaches to tissue engineering.
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Discovery Early Career Researcher Award - Grant ID: DE170100477
Funder
Australian Research Council
Funding Amount
$380,000.00
Summary
The unintended consequences of foreign military training. This project aims to explore the effects of foreign military training on civil-military relations in recipient states. Developed countries are increasingly training developing countries’ militaries. While training is provided to promote traditional security goals, development, and stability, it may have unintended consequences including increasing the prospect of a coup. Using quantitative and qualitative methods, including case studies o ....The unintended consequences of foreign military training. This project aims to explore the effects of foreign military training on civil-military relations in recipient states. Developed countries are increasingly training developing countries’ militaries. While training is provided to promote traditional security goals, development, and stability, it may have unintended consequences including increasing the prospect of a coup. Using quantitative and qualitative methods, including case studies of the US and Australia, the project aims to explain the effects of these training programs, advance the understanding of civil-military relations and produce policy recommendations to improve outcomes of engagement with foreign militaries.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100293
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Cracking the phosphoinositide code. This project seeks to determine how protein interactions with membrane lipids regulate recruitment to cellular organelles, providing new insight into the complex pathways of cellular homeostasis. Controlling the distribution of proteins within cells is critical for cell signalling and membrane trafficking. This is orchestrated by the interaction of specific protein modules with lipids on the surface of different organelles. The phox homology (PX) domain is a l ....Cracking the phosphoinositide code. This project seeks to determine how protein interactions with membrane lipids regulate recruitment to cellular organelles, providing new insight into the complex pathways of cellular homeostasis. Controlling the distribution of proteins within cells is critical for cell signalling and membrane trafficking. This is orchestrated by the interaction of specific protein modules with lipids on the surface of different organelles. The phox homology (PX) domain is a lipid-binding module found in numerous proteins essential for normal cell trafficking and homeostasis, and perturbed in many conditions including immune dysfunction and cancer. This project plans to investigate molecular determinants of PX-lipid association, generating knowledge about protein-membrane interactions required for cellular function. These insights may underpin future drug design.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100793
Funder
Australian Research Council
Funding Amount
$463,180.00
Summary
Unraveling a new cytokine working model in immune cell exhaustion. This project will investigate a novel paradigm of how a key messenger protein can be sensed by fundamental immune cells, preventing their ‘exhaustion’. Immune cell exhaustion is a fundamental mechanism to maintain the internal homeostasis of vertebrates. However, it is often hijacked by pathogens to dampen the defensive capacity of the immune system. And this specific messenger protein is the only known soluble factor that can d ....Unraveling a new cytokine working model in immune cell exhaustion. This project will investigate a novel paradigm of how a key messenger protein can be sensed by fundamental immune cells, preventing their ‘exhaustion’. Immune cell exhaustion is a fundamental mechanism to maintain the internal homeostasis of vertebrates. However, it is often hijacked by pathogens to dampen the defensive capacity of the immune system. And this specific messenger protein is the only known soluble factor that can deliver ‘anti-exhaustion’ signals to immune cells. This study will advance basic knowledge in biochemistry and immunology by combining interdisciplinary and cutting-edge approaches. The expected outcomes include the developing new scientific theories and identifying novel molecular basis of biological processes. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL160100170
Funder
Australian Research Council
Funding Amount
$2,887,531.00
Summary
Scaling in biology: size control at the cell, organelle and organism level. This project aims to decipher the universal mechanisms that coordinate growth with division and thereby dictate the size of the cell. It would investigate this question from the triangulating perspective of evolution using yeast and animal models. It plans to interrogate the complex sub-networks that govern cell size using novel genome-scale reagent sets for systematic genetics and other approaches. It would integrate th ....Scaling in biology: size control at the cell, organelle and organism level. This project aims to decipher the universal mechanisms that coordinate growth with division and thereby dictate the size of the cell. It would investigate this question from the triangulating perspective of evolution using yeast and animal models. It plans to interrogate the complex sub-networks that govern cell size using novel genome-scale reagent sets for systematic genetics and other approaches. It would integrate this data in predictive mathematical models of size control that illuminate how the cell processes size-related information, and how size mechanisms evolve to impact form and function in biology. This research is expected to have commercial applications in biotechnology processes and bioengineering.Read moreRead less
Safe and accessible care for older survivors of psychological trauma. This project aims to improve the safety and accessibility of community aged care services for older survivors of psychological trauma, particularly those from diverse populations. We will co-design and test a practice framework that transforms the conceptual principles of trauma-informed care into actionable care behaviours and processes for implementation. Outcomes will include a world-first roadmap to guide implementation of ....Safe and accessible care for older survivors of psychological trauma. This project aims to improve the safety and accessibility of community aged care services for older survivors of psychological trauma, particularly those from diverse populations. We will co-design and test a practice framework that transforms the conceptual principles of trauma-informed care into actionable care behaviours and processes for implementation. Outcomes will include a world-first roadmap to guide implementation of trauma-informed aged care, as well for policy makers to regulate and monitor its delivery. The project will also increase knowledge about the priorities for change within aged care from the perspective of older trauma survivors, and improve understanding of how best to engage this group in co-design.Read moreRead less
A Method for Analysis of Complexity in Cognitive Processes: Applications to Prediction of Industrial Workloads. The project will develop a method for analysis of cognitive complexity in human and animal cognition. It will contribute to basic research because it will enable equivalences and relative complexities of cognitive functions to be determined, independent of content or methodology. It will have applications to education, because it enables complexities of concepts to be recognised and a ....A Method for Analysis of Complexity in Cognitive Processes: Applications to Prediction of Industrial Workloads. The project will develop a method for analysis of cognitive complexity in human and animal cognition. It will contribute to basic research because it will enable equivalences and relative complexities of cognitive functions to be determined, independent of content or methodology. It will have applications to education, because it enables complexities of concepts to be recognised and appropriate pedagogies determined. It also has application to human factors, especially industrial performance and decision making. It will advance on currrent methods because it enables workload to be analysed and predicted, so that it can be factored into job and system design. Read moreRead less
Speech perception precedes, indexes, and is changed by language acquisition. What is exceptional about human infants is not their sophisticated speech perception (for animals perceive human speech similarly) but their use of speech to regulate linguistic attention and bootstrap language. Using a new validated measure, language specific speech perception (discrimination ability for native minus non-native speech sounds), we can ascertain children's distribution of resources in linguistic tasks. T ....Speech perception precedes, indexes, and is changed by language acquisition. What is exceptional about human infants is not their sophisticated speech perception (for animals perceive human speech similarly) but their use of speech to regulate linguistic attention and bootstrap language. Using a new validated measure, language specific speech perception (discrimination ability for native minus non-native speech sounds), we can ascertain children's distribution of resources in linguistic tasks. This measure will be used in conjunction with a raft of experimental psycholinguistic techniques to investigate speech perception bases of phoneme perception, tone perception, word meaning, reading, and their vestiges in adulthood, to arrive at a dynamic new conception of language development. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100803
Funder
Australian Research Council
Funding Amount
$365,094.00
Summary
Impact of screen time on preschoolers’ social skills and cognitive function. This project aims to determine how the quantity and nature of screen time interacts with parental co-participation to affect pre-schoolers’ social skills and cognitive functioning. Seventy per cent of pre-schoolers exceed current screen time guidelines and this causes considerable concern among Australian parents. This project will assist in evaluating how much, and which types, of screen time have benefits for social ....Impact of screen time on preschoolers’ social skills and cognitive function. This project aims to determine how the quantity and nature of screen time interacts with parental co-participation to affect pre-schoolers’ social skills and cognitive functioning. Seventy per cent of pre-schoolers exceed current screen time guidelines and this causes considerable concern among Australian parents. This project will assist in evaluating how much, and which types, of screen time have benefits for social skills and cognitive functioning. It will also provide insights into the ways parents may best support these outcomes. Findings are expected to provide evidence for policy development and inform programs to support healthy behaviours to give young children the best start in life.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100849
Funder
Australian Research Council
Funding Amount
$364,000.00
Summary
Advanced thermal protection systems to enable Mars return missions. This project aims to advance the modelling of spacecraft heat shield performance to enable future returns to Earth from Mars, where vehicles will encounter heating loads an order of magnitude higher than Lunar returns. Survival depends on sacrificial heat shields which intentionally lose mass through ablation to form a protective layer. Currently, this process cannot be predicted accurately leading to compromised safety, excessi ....Advanced thermal protection systems to enable Mars return missions. This project aims to advance the modelling of spacecraft heat shield performance to enable future returns to Earth from Mars, where vehicles will encounter heating loads an order of magnitude higher than Lunar returns. Survival depends on sacrificial heat shields which intentionally lose mass through ablation to form a protective layer. Currently, this process cannot be predicted accurately leading to compromised safety, excessive weight, and increased mission cost. The expected outcome is an ablation model for vehicle design which, for the first time, is based on experiments with a realistic aerodynamic flow. The significance and benefit of this project is its potential to make ambitious missions such as a Mars return feasible.Read moreRead less