The Structure And Composition Of The T-cell Receptor-CD3 Complex
Funder
National Health and Medical Research Council
Funding Amount
$434,644.00
Summary
Our research will provide a fundamental advance in our understanding of how foreign viruses and pathogens trigger the immune system. Gaining a greater understanding of these central events will facilitate the design of novel therapies to treat immune associated disorders such as transplant rejection, autoimmune disease and some cancers.
The Structure And Composition Of The T-Cell Receptor-CD3 Complex
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
My research will use cutting edge imaging techniques to provide a fundamental advance in our understanding of how foreign viruses and pathogens trigger the immune system. Gaining a greater understanding of these central events will facilitate the design of novel therapies to treat immune associated disorders such as transplant rejection, autoimmune disease and some cancers.
Determinants Of CTL Recruitment Into The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$474,647.00
Summary
The size of CD8+ T cell (CTL) responses is central to their efficacy in virus control, and can be substantially influenced by how effectively they are recruited and expand after infection. This study will determine the impact of both CTL characteristics and antigen abundance on CTL recruitment and expansion after infection. Understanding the nature of these influences will enable a more informed approach to the clinical manipulation of CTL responses.
Following The T Cell Repertoire Over The Human Life Course
Funder
National Health and Medical Research Council
Funding Amount
$473,159.00
Summary
T cells are critical to human health being our second and last line against infectious disease and cancer. However, we know very little about how this important immune compartment operates on a top-down scale. This project will use new technology to resolve this immune compartment to high detail. We will then use this new method to track the T cell compartment from the first years of life and across years of adult life to see how this vital immune compartment evolves along the human life course.
The Impact Of Micropolymorphism Within The T Cell Receptor Genes And Their Target Antigenic Peptides
Funder
National Health and Medical Research Council
Funding Amount
$365,126.00
Summary
T lymphocytes play a pivotal role in the immune system by recognising virus-infected tissue through the use of highly specific T cell receptors (TCRs). This project will investigate the importance of genetic variation in the TCR genes in influencing how we fight infections. Another aim is to examine how the immune system tolerates genetic variation in an infecting virus. Advances in these areas will aid in the development of new "intelligent" vaccines.
Tracking The Impact Of Superinfection With A Common Herpesvirus On T Cell Immunity In Humans
Funder
National Health and Medical Research Council
Funding Amount
$317,775.00
Summary
Human herpesviruses, including cytomegalovirus, infect the vast majority of people and can cause serious complications in healthy people and in immune suppressed transplant patients. The development of vaccines to treat herpesvirus infections remain a signficant priority. However it is not known what impact repeated exposure to different strains of these viriuses has upon immunity. This study will investigate the impact of exposure to different strains of cytomegalovirus on immunity in healthy i ....Human herpesviruses, including cytomegalovirus, infect the vast majority of people and can cause serious complications in healthy people and in immune suppressed transplant patients. The development of vaccines to treat herpesvirus infections remain a signficant priority. However it is not known what impact repeated exposure to different strains of these viriuses has upon immunity. This study will investigate the impact of exposure to different strains of cytomegalovirus on immunity in healthy individuals and transplant patients.Read moreRead less
Determining The Biological Significance Of Allelic Sequence Variation Within The T Cell Receptor Loci
Funder
National Health and Medical Research Council
Funding Amount
$627,549.00
Summary
T lymphocytes play a pivotal role in the immune system by recognising virus-infected tissue through the use of highly specific T cell receptors (TCRs). This project will investigate the importance of genetic variation in the TCR genes in influencing how we fight infections. Advances in these areas will assist in understanding susceptibility to some autoimmune diseases as well as aiding in the development of new "intelligent" vaccines and individualised therapeutics.
Antigen Recognition By CD1a-restricted T Cells In The Human Immune System
Funder
National Health and Medical Research Council
Funding Amount
$615,520.00
Summary
Human immunity requires protective T cells that target foreign molecules for removal. Even though substantial populations of T cells exist that recognise lipid molecules, little is known about their basic biology. We will identify and characterise lipid reactive human T cells and examine their response to foreign or self-lipids expressed by infectious organisms and host cells. This work will have important implications in understanding lipid reactive T cells in health and disease.