The Structure And Composition Of The T-cell Receptor-CD3 Complex
Funder
National Health and Medical Research Council
Funding Amount
$434,644.00
Summary
Our research will provide a fundamental advance in our understanding of how foreign viruses and pathogens trigger the immune system. Gaining a greater understanding of these central events will facilitate the design of novel therapies to treat immune associated disorders such as transplant rejection, autoimmune disease and some cancers.
The Structure And Composition Of The T-Cell Receptor-CD3 Complex
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
My research will use cutting edge imaging techniques to provide a fundamental advance in our understanding of how foreign viruses and pathogens trigger the immune system. Gaining a greater understanding of these central events will facilitate the design of novel therapies to treat immune associated disorders such as transplant rejection, autoimmune disease and some cancers.
Characterisation And Development Of Type-2 NKT Cells
Funder
National Health and Medical Research Council
Funding Amount
$853,885.00
Summary
Humans defend themselves from foreign pathogens by mounting a protective immune response. Type-2 NKT cells recognise foreign lipid molecules and play a key role in immunity. This project is designed to understand to how Type-2 NKT cells develop within the body, how they recognise lipid molecules and how they carry out their immune functions. This work will have important implications in understanding the role of NKT cells in human health and disease.
NKT cells are a type of lymphocyte with the ability to prevent a broad range of diseases including cancer, autoimmunity, infection and graft rejection. Sometimes, NKT cells also cause diseases, including allergy and atherosclerosis. This project will investigate how NKT cells become activated in these diseases by studying their surface receptors and what these receptors interact with.
Recognition Of Lipid Antigens By CD1d-restricted Type-2 NKT Cells
Funder
National Health and Medical Research Council
Funding Amount
$417,684.00
Summary
Protection against infection depends on T cells, which recognise and target foreign molecules called antigens via a specialized antigen receptor known as a T cell receptor (TCR). This project focuses on a specialised population of T cells called Natural Killer T (NKT) cells that recognise lipid antigens. The work outlined in this grant will increase our understanding of how different TCRs can recognise diverse lipid antigens thus providing insight into the role of NKT cells in the immune system.
T-cells: The Key To Unlocking Immunity Against Aggressive Lymphoma
Funder
National Health and Medical Research Council
Funding Amount
$322,951.00
Summary
By investigating several aspects of patients’ immune defenses against the cancer cells in Diffuse large B-cell lymphoma, this project will provide critical insights on ways to harness the patient’s own immune system to effectively mount anti-tumour responses. These results will pave the way for future therapeutic strategies to successfully treat and prevent lymphoma.
Determinants Of CTL Recruitment Into The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$474,647.00
Summary
The size of CD8+ T cell (CTL) responses is central to their efficacy in virus control, and can be substantially influenced by how effectively they are recruited and expand after infection. This study will determine the impact of both CTL characteristics and antigen abundance on CTL recruitment and expansion after infection. Understanding the nature of these influences will enable a more informed approach to the clinical manipulation of CTL responses.