Plasticity of gastrointestinal vagal afferents. The aim of this project is to identify how leptin modulates specific subtypes of vagal afferent within the gut and the plasticity of this system under different dietary conditions. This proposed project will substantially increase understanding of the interactions between leptin, known to influence food intake, and vagal afferent satiety signals. It will also increase understanding of how these interactions alter in obesity and ultimately provide t ....Plasticity of gastrointestinal vagal afferents. The aim of this project is to identify how leptin modulates specific subtypes of vagal afferent within the gut and the plasticity of this system under different dietary conditions. This proposed project will substantially increase understanding of the interactions between leptin, known to influence food intake, and vagal afferent satiety signals. It will also increase understanding of how these interactions alter in obesity and ultimately provide targets and/or concepts for the pharmacotherapy of obesity.Read moreRead less
Target detection in three-dimensional optic flow. This project aims to understand the behavioural, neural, and computational mechanisms underlying the visualisation of moving targets. Insects have poorer eyesight and smaller brains than humans, but can chase small targets at high speed. This project will use intracellular electrophysiology, information content analysis and model development to decipher the underlying neural tuning mechanisms of hoverflies, which could suggest advanced computatio ....Target detection in three-dimensional optic flow. This project aims to understand the behavioural, neural, and computational mechanisms underlying the visualisation of moving targets. Insects have poorer eyesight and smaller brains than humans, but can chase small targets at high speed. This project will use intracellular electrophysiology, information content analysis and model development to decipher the underlying neural tuning mechanisms of hoverflies, which could suggest advanced computational optimisation and miniaturisation. The project may generate algorithms for rapid and reliable information extraction from large, noisy inputs, useful for developing unmanned vehicles and in Big Data analysis. The results could be useful in developing anti-collision control systems in vehicles using less computational power.Read moreRead less
Ultradian rhythms in basal metabolism; relationship to thermoregulation, cardiovascular function and behavioural arousal. Results from this project will be of basic theoretical biological importance, and may well provide a foundation for understanding basal metabolic regulation and its link with cardiovascular function. Our findings may provide a new foundation for discovering strategies that alter basal metabolic rate in a manner that improves health and reduces the incidence of obesity related ....Ultradian rhythms in basal metabolism; relationship to thermoregulation, cardiovascular function and behavioural arousal. Results from this project will be of basic theoretical biological importance, and may well provide a foundation for understanding basal metabolic regulation and its link with cardiovascular function. Our findings may provide a new foundation for discovering strategies that alter basal metabolic rate in a manner that improves health and reduces the incidence of obesity related disease such as heart attack and stroke. Thus this research proposal is of special relevance to National Research Priority 2: Promoting and Maintaining Good Health. Obesity and obesity-related medical conditions particularly affect older people, so that our research is also highly relevant to National Research Priority 2 sub-areas: Ageing well, Ageing productively.Read moreRead less
Cellular bases of enteric neural circuitry underlying gut propulsion. This project aims to investigate the neural bases of behaviour in the mammalian gut. The Enteric Nervous System (ENS) plays a critical role in the propulsion of intestinal contents. This project expects to establish how specific functional classes of enteric neurons control propulsion along the gut. By recording the simultaneous neural activity from hundreds of different functional classes of enteric nerve cells simultaneously ....Cellular bases of enteric neural circuitry underlying gut propulsion. This project aims to investigate the neural bases of behaviour in the mammalian gut. The Enteric Nervous System (ENS) plays a critical role in the propulsion of intestinal contents. This project expects to establish how specific functional classes of enteric neurons control propulsion along the gut. By recording the simultaneous neural activity from hundreds of different functional classes of enteric nerve cells simultaneously, whilst recording intestinal muscle electrical activity and the movements of the gut wall, the project expects to identify which enteric neurochemical classes of neurons generate specific motor patterns along the intestine.Read moreRead less
Comparative analysis of sensor noise for target detection in dragonfly eyes. Dragonflies hunt tiny prey in the low-light conditions of late dusk, a signal-to-noise problem that challenges any engineered system. Using a comparative approach across dragonfly species, we aim to use novel optical and physiological measures to determine how sensors with noise underlie target-detection, in varying scene brightness. The project outcomes will be a comparative characterisation of signal-to-noise measures ....Comparative analysis of sensor noise for target detection in dragonfly eyes. Dragonflies hunt tiny prey in the low-light conditions of late dusk, a signal-to-noise problem that challenges any engineered system. Using a comparative approach across dragonfly species, we aim to use novel optical and physiological measures to determine how sensors with noise underlie target-detection, in varying scene brightness. The project outcomes will be a comparative characterisation of signal-to-noise measures of dragonfly eye optics (including eye size) and early sensory neurons. We will match detection thresholds with downstream target-detecting neurons and dragonfly behaviour. This will provide insight into signal detection, which is a ubiquitous problem across information processing, computer vision and autonomous systems.Read moreRead less
Afferent stimulation-induced plasticity and its functional significance. Certain regions of the brain can reorganise (plasticity) during motor learning or when there is damage to peripheral nerves or muscles. There is a large body of evidence for these plastic changes in animals. Until recently data showing that similar changes occurred in humans was limited. However, we have recently demonstrated that certain patterns of peripheral stimulation can indeed induce similar changes in human subjects ....Afferent stimulation-induced plasticity and its functional significance. Certain regions of the brain can reorganise (plasticity) during motor learning or when there is damage to peripheral nerves or muscles. There is a large body of evidence for these plastic changes in animals. Until recently data showing that similar changes occurred in humans was limited. However, we have recently demonstrated that certain patterns of peripheral stimulation can indeed induce similar changes in human subjects. These findings are important for our understanding of the mechanisms of motor control and learning.Read moreRead less
Target detection in visual clutter. The interdisciplinary nature of the project will offer a stimulating environment for training a postdoctoral worker in the hot topic of computational neuroscience. While computationally expensive solutions to moving target detection in clutter have been implemented using conventional engineering, this project will offer insight into the efficiency of the biological brain (with benefit of millions of years of evolution towards compact, economical and optimal so ....Target detection in visual clutter. The interdisciplinary nature of the project will offer a stimulating environment for training a postdoctoral worker in the hot topic of computational neuroscience. While computationally expensive solutions to moving target detection in clutter have been implemented using conventional engineering, this project will offer insight into the efficiency of the biological brain (with benefit of millions of years of evolution towards compact, economical and optimal solutions). The results will assist development of efficient artificial intelligence. It will also assist our ongoing collaborations with defence partners to develop and apply algorithms in artificial vision systems. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100548
Funder
Australian Research Council
Funding Amount
$359,000.00
Summary
Neural and robotic correlates of predictive coding and selective attention. Whether a human catching a ball, a dog leaping at a frisbee or a dragonfly hunting prey amidst a swarm, brains both large and small have evolved the ability to focus attention on one moving target, even in the presence of distracters. This project aims to investigate how brains solve this challenging problem by recording the activity of dragonfly neurons that selectively attend to one target whilst ignoring others. The p ....Neural and robotic correlates of predictive coding and selective attention. Whether a human catching a ball, a dog leaping at a frisbee or a dragonfly hunting prey amidst a swarm, brains both large and small have evolved the ability to focus attention on one moving target, even in the presence of distracters. This project aims to investigate how brains solve this challenging problem by recording the activity of dragonfly neurons that selectively attend to one target whilst ignoring others. The project aims to examine how expectation and attention are encoded in the brain and will build an autonomous robot using computational models bio-inspired from this neuronal processing. Robots capable of visually perceiving and interacting with targets in natural environments have applications in health, surveillance and defence.Read moreRead less
Central pathways regulating visceral pain. This project aims to investigate the neural pathways within the spinal cord and brain processing colorectal pain perception. The project aims to identify the spinal cord neurons relaying colorectal signalling into the brain and the influence of descending modulation from the brainstem upon these pathways. The outcomes will greatly benefit fundamental understanding of the central pathways processing visceral pain.
Neural mechanisms for visual target detection and attention in complex scenes. This project will study neurons in the insect brain that solve one of the biggest problems for computer vision systems - tracking the motion of tiny targets moving against strongly camouflaged backgrounds. The results will be used to develop a novel biologically inspired model for target tracking with applications for smart cameras and robotics.