The genomic programming of complex organisms. The project will have far-reaching consequences in medicine, agriculture, biotechnology, engineering, information science and associated industries. It will provide a platform for the rationalization of genetic epidemiology and genetic improvement programs, the development of a wide range of new diagnostics and therapies, the development of new core technologies and practical approaches in genetics and genetic diversity, a framework for advanced gen ....The genomic programming of complex organisms. The project will have far-reaching consequences in medicine, agriculture, biotechnology, engineering, information science and associated industries. It will provide a platform for the rationalization of genetic epidemiology and genetic improvement programs, the development of a wide range of new diagnostics and therapies, the development of new core technologies and practical approaches in genetics and genetic diversity, a framework for advanced genetic engineering, the development of new principles and systems for information storage and transmission, and the design of artificial systems capable of self-referential assembly in other environments.Read moreRead less
Intelligent Biomedical System Modelling and Multi-modality Image Analysis to Maximize Diagnostic Information from Medical Imaging. Medical imaging is an essential part of our Australian modern health care system and plays an important role in the diagnosis, treatment planning and decision making and assessment of treatment of patients. This project aims to maximize the benefit of federal government healthcare investment through intelligent biomedical system modelling in conjunction with multi-mo ....Intelligent Biomedical System Modelling and Multi-modality Image Analysis to Maximize Diagnostic Information from Medical Imaging. Medical imaging is an essential part of our Australian modern health care system and plays an important role in the diagnosis, treatment planning and decision making and assessment of treatment of patients. This project aims to maximize the benefit of federal government healthcare investment through intelligent biomedical system modelling in conjunction with multi-modality image analysis to extract crucial additional information for accurate diagnosis and improved treatment, which will not only lead to a major scientific advancement, but also deliver significant social benefits.Read moreRead less
Designing an Intelligent Process Operation Management System. The complexity and sophistication of current generation of industrial processes, and the growing need for autonomous agents that control physical systems, motivate the need for the development of an intelligent process operation management system. In this project, the innovative integration of theories from different scientific fields (computer systems, process engineering, systems and control engineering) provides an excellent platfo ....Designing an Intelligent Process Operation Management System. The complexity and sophistication of current generation of industrial processes, and the growing need for autonomous agents that control physical systems, motivate the need for the development of an intelligent process operation management system. In this project, the innovative integration of theories from different scientific fields (computer systems, process engineering, systems and control engineering) provides an excellent platform for development of a smart data management tool, to oversee the major operational tasks within the plant and help the operators and engineers to make more informed decisions. Direct application of the techniques developed in this study to a pilot case study, could be used as a benchmark to show the potential benefits that can be gained through smart information use and data management.Read moreRead less
Why conserve genetic variation? Is this misdirected effort or a crucial concern? In attempting to conserve populations of threatened plants, ecosystem managers must prioritise allocation of resources to both immediate and long-term threats, including loss of genetic variation. This study will determine the importance of maintaining existing genetic variation within populations of several species in a major Australian plant group. As well as advancing theory in the area of plant ecological genet ....Why conserve genetic variation? Is this misdirected effort or a crucial concern? In attempting to conserve populations of threatened plants, ecosystem managers must prioritise allocation of resources to both immediate and long-term threats, including loss of genetic variation. This study will determine the importance of maintaining existing genetic variation within populations of several species in a major Australian plant group. As well as advancing theory in the area of plant ecological genetics and evolutionary biology, our results will provide a stronger scientific basis for the development of conservation policy and management decisions for conserving threatened plant species. Read moreRead less
Tracing the origins of stress in the symbionts of reef-building corals. Symbiotic dinoflagellates of corals are critical to the world's major tropical reef ecosystems. Recent work in our laboratories and others has revealed that these algae are sensitive to a wide array of stresses (including climate change) and hence may be the ?Achilles Heel? of reef ecosystems. This project will identify the key genes and processes in these algae using expressed sequence tags and microarray technology. On th ....Tracing the origins of stress in the symbionts of reef-building corals. Symbiotic dinoflagellates of corals are critical to the world's major tropical reef ecosystems. Recent work in our laboratories and others has revealed that these algae are sensitive to a wide array of stresses (including climate change) and hence may be the ?Achilles Heel? of reef ecosystems. This project will identify the key genes and processes in these algae using expressed sequence tags and microarray technology. On this basis, the underlying molecular mechanisms of these stress responses and their genetic diversity will be studied in order to better understand the differential susceptibility of reef-building corals to bleaching.Read moreRead less
A functional genomic approach for understanding metal ion adaptation in marine cyanobacteria. Unicellular marine cyanobacteria constitute 20-40% of total marine chlorophyll biomass and carbon fixation, and hence significantly impact the global carbon cycle and are very relevant to combating global warming. This research will reveal some of the major mechanisms by which marine cyanobacteria have adapted to metal levels in coastal and oligotrophic environments. Thus these results will help us und ....A functional genomic approach for understanding metal ion adaptation in marine cyanobacteria. Unicellular marine cyanobacteria constitute 20-40% of total marine chlorophyll biomass and carbon fixation, and hence significantly impact the global carbon cycle and are very relevant to combating global warming. This research will reveal some of the major mechanisms by which marine cyanobacteria have adapted to metal levels in coastal and oligotrophic environments. Thus these results will help us understand the distribution and diversity of these organisms in relation to global primary productivity. They will also lead to the development of more robust biomarkers for metal stress and pollution in coastal environments.Read moreRead less
Uncertain Information Processing for Situation Awareness and Dynamic Decision-Making in Emergency Management. The Australian national counter-terrorism committee indicates that Australia should have a strong intelligence-led prevention and preparedness to support Australia on risk management, emergency services and maintaining capabilities to manage various types of terrorist attacks. The proposed situation awareness support technique can be used to develop situation analysis software systems or ....Uncertain Information Processing for Situation Awareness and Dynamic Decision-Making in Emergency Management. The Australian national counter-terrorism committee indicates that Australia should have a strong intelligence-led prevention and preparedness to support Australia on risk management, emergency services and maintaining capabilities to manage various types of terrorist attacks. The proposed situation awareness support technique can be used to develop situation analysis software systems or directly support Australia government agencies and industries to correctly assess a situation, increase awareness for crisis problems, and therefore improve emergency management and decision-making effectiveness, in particular, for avoiding disaster problems in the first place and preparing plans for those that undoubtedly will occur. Read moreRead less
Organisation, expression and diversity of the sub-telomeric regions of the ancient eukaryote, Giardia duodenalis. We propose to extend our findings on the extreme plasticity of the structure and organisation of the sub-telomeric region of the complete genome of Giardia by more extensive chromosome walking, and comparison of different isolates. These regions are subject to gene conversion, transcriptional silencing, gene mobility, recombination, variable surface protein expression, subtelomeric i ....Organisation, expression and diversity of the sub-telomeric regions of the ancient eukaryote, Giardia duodenalis. We propose to extend our findings on the extreme plasticity of the structure and organisation of the sub-telomeric region of the complete genome of Giardia by more extensive chromosome walking, and comparison of different isolates. These regions are subject to gene conversion, transcriptional silencing, gene mobility, recombination, variable surface protein expression, subtelomeric instability and the insertion of transposable elements, a dynamic balance between structural conservation and rapid evolution. This is a rare opportunity to understand the forces at work in moulding eukaryotic sub-telomeric sequences because Giardia is not constrained by sexual homogenisation and the dynamic variability is retained.Read moreRead less
Mechanosensitive properties and modulation of N-methyl-D-aspartate (NMDA) receptors by lipid environment. This project will provide new information about the molecular determinants which influence NMDA receptor channel gating that will significantly advance our understanding of a link between NMDA receptor function and many neurodegenerative diseases as well as pain and learning and memory. The outcomes of this project may lead to the discovery of novel lipid-based biomaterials for application i ....Mechanosensitive properties and modulation of N-methyl-D-aspartate (NMDA) receptors by lipid environment. This project will provide new information about the molecular determinants which influence NMDA receptor channel gating that will significantly advance our understanding of a link between NMDA receptor function and many neurodegenerative diseases as well as pain and learning and memory. The outcomes of this project may lead to the discovery of novel lipid-based biomaterials for application in medicine and the drug industry. This research is highly significant in relation to human health. The biological and nutritional aspects of polyunsaturated lipids and dietary fish oils have long been recognized. Thus this project will provide further knowledge that could benefit the health of the nation with consequent reduced health care costs.Read moreRead less
Formally-Based Security Evaluation Procedures. Guaranteeing information security is of critical national importance, especially in the current political climate. Devices intended to safeguard Australia's electronic communications must be proven secure using leading-edge techniques. Currently, evaluation of such devices relies on informal procedures and the experience of individuals. This project will introduce more rigour into security evaluations by adapting techniques from the fields of saf ....Formally-Based Security Evaluation Procedures. Guaranteeing information security is of critical national importance, especially in the current political climate. Devices intended to safeguard Australia's electronic communications must be proven secure using leading-edge techniques. Currently, evaluation of such devices relies on informal procedures and the experience of individuals. This project will introduce more rigour into security evaluations by adapting techniques from the fields of safety analysis and formal methods. In particular, mathematical concepts will be introduced using notations suitable for use by security personnel with no prior formal methods experience. The outcomes of this project will enable more efficient and effective information security evaluations.Read moreRead less