Mapping networks governing cell state plasticity: how, where and when? Single cell organisms are the basic unit of life, yet, if they had not developed the ability to change cell states we would not exist today. Changing cell states lies at the core of almost every developmental and disease process in multicellular organisms. Building upon our fundamental discovery that stem cells and non-stem cells readily interconvert, we will now incorporate innovative cell systems and the development of our ....Mapping networks governing cell state plasticity: how, where and when? Single cell organisms are the basic unit of life, yet, if they had not developed the ability to change cell states we would not exist today. Changing cell states lies at the core of almost every developmental and disease process in multicellular organisms. Building upon our fundamental discovery that stem cells and non-stem cells readily interconvert, we will now incorporate innovative cell systems and the development of our new multi-layered systems biology strategy to elucidate the first comprehensive understanding of the cell biology that underlies cell state changes. These studies are a major step toward understanding the fundamentals of life. Read moreRead less
System identification of microstructure in the brain using magnetic resonance. Magnetic Resonance Imaging technologies will be exploited to probe the microstructure of the brain, using powerful Bayesian optimisation techniques and innovative uses of magnetic resonance. The project will in particular develop non-invasive imaging methods to quantify iron content in the brain, important for research on dementia and Alzheimer's disease.
3'UTR switching in eukaryotic cells. The project aims to uncover conserved features fundamental to the mechanism and function of post-transcriptional gene-expression control. RNA systems interface the executive functions of DNA and the worker functions of proteins. mRNA often dictates the level, timing and location of protein synthesis. This project will use RNA-sequencing and bespoke bioinformatics to probe global RNA-dynamics. Mixing yeast-genetics with RNA-technologies, it focuses on 3’ untra ....3'UTR switching in eukaryotic cells. The project aims to uncover conserved features fundamental to the mechanism and function of post-transcriptional gene-expression control. RNA systems interface the executive functions of DNA and the worker functions of proteins. mRNA often dictates the level, timing and location of protein synthesis. This project will use RNA-sequencing and bespoke bioinformatics to probe global RNA-dynamics. Mixing yeast-genetics with RNA-technologies, it focuses on 3’ untranslated region (UTR) dynamics in eukaryotic cell biology. This project expects to significantly advance the understanding of eukaryotic gene function and gene regulation, critical in an age of personalised genomic medicine.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100047
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre for Accelerated Future Crop Development . The Centre will create a new generation of leaders in the implementation of advanced gene and field technologies for the benefit of the Australian agriculture industry. We will build the workforce and foundations that will drive translation of breakthroughs in advanced breeding, phenotyping and genetic technologies into higher-yielding crops. This will increase productivity across the sector and create new markets. Our technical trai ....ARC Training Centre for Accelerated Future Crop Development . The Centre will create a new generation of leaders in the implementation of advanced gene and field technologies for the benefit of the Australian agriculture industry. We will build the workforce and foundations that will drive translation of breakthroughs in advanced breeding, phenotyping and genetic technologies into higher-yielding crops. This will increase productivity across the sector and create new markets. Our technical training programs for graduates, trainees and industry will interface with best evidence-based practices in the wider socio-economic, regulatory and environmental contexts. Coupled with community and stakeholder engagement, the Centre will redefine and secure Australia’s future in agriculture. Read moreRead less
Microcantilevers for multifrequency atomic force microscopy. This project aims to design a microcantilever with high-performing sensors more sensitive and with better noise performance than the typical optical system used in commercial Atomic Force Microscopes (AFMs). The AFM, a nanotechnology instrument, uses a microcantilever (with an extremely shape probe) to interrogate a sample surface. It has made important discoveries in nanotechnology, life sciences, nanomachining, material science and d ....Microcantilevers for multifrequency atomic force microscopy. This project aims to design a microcantilever with high-performing sensors more sensitive and with better noise performance than the typical optical system used in commercial Atomic Force Microscopes (AFMs). The AFM, a nanotechnology instrument, uses a microcantilever (with an extremely shape probe) to interrogate a sample surface. It has made important discoveries in nanotechnology, life sciences, nanomachining, material science and data storage systems. Despite its success, the technique’s spatial resolution and quantitative measurements are limited. This project could lead to breakthrough technologies such as atomic force spectroscopy to study elastic modulus of nanostructures, and establish Australia's prominence in this emerging field.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100114
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
High Throughput Cell Genomics Centre. High throughput cell genomics centre: This project will establish a high throughput cell genomics centre comprising a Fluidigm C1™ Single-Cell AutoPrep and BioMark™ HD system providing researchers with the most innovative approach to single cell and small population analyses. The instruments will enable the unique capability to conduct single cell transcriptome analysis and high throughput gene expression, SNP genotyping and copy number variation analysis as ....High Throughput Cell Genomics Centre. High throughput cell genomics centre: This project will establish a high throughput cell genomics centre comprising a Fluidigm C1™ Single-Cell AutoPrep and BioMark™ HD system providing researchers with the most innovative approach to single cell and small population analyses. The instruments will enable the unique capability to conduct single cell transcriptome analysis and high throughput gene expression, SNP genotyping and copy number variation analysis as well as validation of next generation sequencing data. The information generated is crucial to advancing knowledge in important research fields including infection and immunity, regenerative medicine, immune responses, biomarker discovery, drug discovery, biotechnology and agriculture.Read moreRead less
Improving transient performance for systems with multiple inputs/outputs. This project aims to develop and test new mathematical techniques for the improvement of transient performance in tracking control systems. The fundamental problem to be addressed will be the design of controllers to rapidly track constant and time varying target reference signals without overshooting or undershooting for multiple-input multiple-output systems/plants. These new methods aim to offer improved accuracy and sp ....Improving transient performance for systems with multiple inputs/outputs. This project aims to develop and test new mathematical techniques for the improvement of transient performance in tracking control systems. The fundamental problem to be addressed will be the design of controllers to rapidly track constant and time varying target reference signals without overshooting or undershooting for multiple-input multiple-output systems/plants. These new methods aim to offer improved accuracy and speed in many engineering applications.Read moreRead less
Need for Speed: Towards Controller Design Automation for Power Electronics. This project aims to address the need for advanced controller design automation tools for power electronics systems by advocating a novel design paradigm. The project expects to seek breakthroughs in the modelling and optimisation aspects of power electronics systems and generate new automation tools for existing and emerging power electronics applications. Expected outcome include significant reduction of controller dev ....Need for Speed: Towards Controller Design Automation for Power Electronics. This project aims to address the need for advanced controller design automation tools for power electronics systems by advocating a novel design paradigm. The project expects to seek breakthroughs in the modelling and optimisation aspects of power electronics systems and generate new automation tools for existing and emerging power electronics applications. Expected outcome include significant reduction of controller development cycle time and cost, minimisation of human oversight, and maximisation of system performance. Profound benefits include maintaining Australia’s leadership in a wide range of sectors such as renewable energy and electric vehicles demanding rapid development cycles and realisation of Australia’s zero-carbon vision. Read moreRead less
Reliable and efficient algorithms for modelling dynamical systems from data. Mathematical and computational models are increasingly important in diverse areas of science and engineering including aircraft and automotive design, robotics, medical sensing, and biology. However, finding an accurate model remains a difficult task. This project will develop new methods to reliably find highly accurate models from recorded data.
A New Approach to High-Performance Control of Nonlinear Systems. The coming generation of robots are highly mobile and will interact significantly with their environment, each other, and human collaborators. However, this leads to highly coupled nonlinear dynamical behaviour, and achieving accurate and reliable control of these systems is pushing current control theory to breaking point. This project aims to develop a new approach to control of nonlinear systems based on contraction theory and c ....A New Approach to High-Performance Control of Nonlinear Systems. The coming generation of robots are highly mobile and will interact significantly with their environment, each other, and human collaborators. However, this leads to highly coupled nonlinear dynamical behaviour, and achieving accurate and reliable control of these systems is pushing current control theory to breaking point. This project aims to develop a new approach to control of nonlinear systems based on contraction theory and convex optimisation, extending the power of optimisation-based control from linear to non-linear systems. The project is expected to lead to new theoretical developments, constructive algorithms and software, and experimental demonstrations on a range of platforms including bipedal walking robots and underwater robots.Read moreRead less