System identification of microstructure in the brain using magnetic resonance. Magnetic Resonance Imaging technologies will be exploited to probe the microstructure of the brain, using powerful Bayesian optimisation techniques and innovative uses of magnetic resonance. The project will in particular develop non-invasive imaging methods to quantify iron content in the brain, important for research on dementia and Alzheimer's disease.
Understanding the robustness and plasticity of metabolite concentrations. This project aims to further the understanding of how organisms mitigate the effects of changing environment by altering metabolite concentrations, important for food quality, energetics, and health. Through this understanding, the project provides the potential to precisely tailor metabolic intervention strategies, highly beneficial for applied sciences. The expected outcome of the project is a suite of computational appr ....Understanding the robustness and plasticity of metabolite concentrations. This project aims to further the understanding of how organisms mitigate the effects of changing environment by altering metabolite concentrations, important for food quality, energetics, and health. Through this understanding, the project provides the potential to precisely tailor metabolic intervention strategies, highly beneficial for applied sciences. The expected outcome of the project is a suite of computational approaches that allow for integration of large-scale data with networks to predict metabolite concentration ranges. This will provide significant benefit with the aim of maintaining outstanding research in Australia, and has clear potential for improved human health and enhanced food quality via metabolic reprogramming.Read moreRead less
Systems modelling of the cardiac fibroblast. The cardiac fibroblast is a specialised cell in the heart. New evidence shows that this cell type is central to heart function, but relatively little is known about how and why. This project will develop mathematical modelling to characterise how the cardiac fibroblast regulates the functioning of the adult heart.
Stochastic modelling of telomere length regulation in ageing research. This project will design innovative stochastic models to explore the molecular mechanisms governing telomere length regulation and their critical roles in determining cell fate. Computer simulations will provide testable predictions regarding the crucial functions of noise in generating the heterogeneity of telomere length.
Emergence of modular structure in complex systems. Complex systems pervade our world, but are still poorly understood. Self-contained modules provide the most widespread and effective way of reducing and managing complexity, but the way they form in natural systems remains largely a mystery. This study investigates mechanisms that contribute to module formation in complex networks, including adaptation, clustering, enslavement, feedback, phase change and synchronisation. Outcomes will include in ....Emergence of modular structure in complex systems. Complex systems pervade our world, but are still poorly understood. Self-contained modules provide the most widespread and effective way of reducing and managing complexity, but the way they form in natural systems remains largely a mystery. This study investigates mechanisms that contribute to module formation in complex networks, including adaptation, clustering, enslavement, feedback, phase change and synchronisation. Outcomes will include insights into the organisation and functioning of many complex systems, including the Internet, ecological communities and genetic networks. Practical outcomes will include new modelling tools and applications both to evolutionary computation and the design and control of large information networks.Read moreRead less
Modelling, Identification and Control of Complex Networks. Australia has been well known for its leading research in systems and control and many real-world applications in, for instance, telecommunications, defence, power grids and life sciences. This project will further promote Australia's leading position in the emerging new research field - complex networks by theoretical breakthrough in modelling, identification and control of complex networks, and cutting-edge platform technology that can ....Modelling, Identification and Control of Complex Networks. Australia has been well known for its leading research in systems and control and many real-world applications in, for instance, telecommunications, defence, power grids and life sciences. This project will further promote Australia's leading position in the emerging new research field - complex networks by theoretical breakthrough in modelling, identification and control of complex networks, and cutting-edge platform technology that can help Australian energy industry to reduce greenhouse emissions. It will also result in education of the next generation research leaders in this emerging field.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101191
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Formation of the osteocyte network in bone matrix. The formation of new bone, which occurs throughout life for bone renewal and acutely after fractures, entraps a network of cells that can detect micro-damage and direct repair mechanisms. Mathematical and computational methods will be used to understand how this network can lead to a self-detecting and self-repairing biomaterial.
Phylodynamics for Single Cell Genomics . This project generates the mathematical framework required to look at single cell data in developmental systems and tissues. All cells in a multi-cellular organism derive from a single ancestral cell, generally the fertilised egg cell. Phylodynamics provides a framework to analyse and model this data, by connecting the shared ancestry of cells in an organism to the cell population and tissue dynamics. By developing the mathematical and statistical foundat ....Phylodynamics for Single Cell Genomics . This project generates the mathematical framework required to look at single cell data in developmental systems and tissues. All cells in a multi-cellular organism derive from a single ancestral cell, generally the fertilised egg cell. Phylodynamics provides a framework to analyse and model this data, by connecting the shared ancestry of cells in an organism to the cell population and tissue dynamics. By developing the mathematical and statistical foundations for the analysis of single cell data in a phylodynamic framework we will establish a powerful new computational tools for the analysis of tissues and developmental processes. Read moreRead less
Mathematical Modelling of the Mechanobiology of Arterial Plaque Growth. Plaque growth is a chronic inflammatory response induced by the interactions between endothelial cells, lipids, monocytes/macrophages, smooth muscle cells and platelets in the arteries. It involves many different biological processes, such as lipid deposition, inflammation and angiogenesis, and their interactions with the microcirculation. To understand the underlying mechanobiology, we propose to develop a mathematical mode ....Mathematical Modelling of the Mechanobiology of Arterial Plaque Growth. Plaque growth is a chronic inflammatory response induced by the interactions between endothelial cells, lipids, monocytes/macrophages, smooth muscle cells and platelets in the arteries. It involves many different biological processes, such as lipid deposition, inflammation and angiogenesis, and their interactions with the microcirculation. To understand the underlying mechanobiology, we propose to develop a mathematical model to interpret plaque growth by integrating these dynamic biological processes. It will offer a systematic rational understanding of plaque growth. New models will be provided to better interpret biological data and contribute to our knowledge in quantifying complex biological mechanisms during growth and development.Read moreRead less
Control and safety monitoring systems for large scale irrigation networks. The water losses in irrigation channels in Australia are large, but they can be substantially reduced by employing advanced control and monitoring systems, leading to significant environmental benefits. Due to the large size of the irrigation networks, design of control and monitoring systems represents technical challenges for which there are currently no good methodologies. In this project we will develop design methodo ....Control and safety monitoring systems for large scale irrigation networks. The water losses in irrigation channels in Australia are large, but they can be substantially reduced by employing advanced control and monitoring systems, leading to significant environmental benefits. Due to the large size of the irrigation networks, design of control and monitoring systems represents technical challenges for which there are currently no good methodologies. In this project we will develop design methodologies, and in particular we will focus on issues relating to the communication constraints arising since data are transmitted over a radio network and the trade off between robustness and performance in centralised and decentralised designs.Read moreRead less