Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying ....Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying regulators of lipid metabolism. The large diversity in humans necessitate sufficient sample sizes to identify true genetic regulators, but to date techniques capturing phenotypic data (lipids) have been largely limited. It is anticipated that this study will identify new regulators of lipid metabolism in humans.Read moreRead less
About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock a ....About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock and its role in the normal biology of the heart. New data will significantly enhance our understanding of the biology of MR and cortisol for the circadian time keeping function in peripheral tissues, and gain a clearer understand how our heart cells adapt to environmental circadian disruptors such as shift work. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100117
Funder
Australian Research Council
Funding Amount
$1,275,000.00
Summary
A platform consortium for integrated 'systems-omics' research. The proposal aims to establish a multi-institutional integrated ‘systems-omics’ platform across two of Victoria’s leading research universities, and associated research institutes. The platform will consist of two cutting edge ultra-high resolution mass spectrometers (i) a Thermo Scientific Orbitrap Fusion LUMOS for rapid and comprehensive metabolomic profiling and detailed structural characterization, located at La Trobe University ....A platform consortium for integrated 'systems-omics' research. The proposal aims to establish a multi-institutional integrated ‘systems-omics’ platform across two of Victoria’s leading research universities, and associated research institutes. The platform will consist of two cutting edge ultra-high resolution mass spectrometers (i) a Thermo Scientific Orbitrap Fusion LUMOS for rapid and comprehensive metabolomic profiling and detailed structural characterization, located at La Trobe University, and (ii) a Thermo Scientific Orbitrap Q Exactive HFX for high-throughput, deep and reproducible quantitative proteome analysis, located at the University of Melbourne.This platform will address applications across the agri-biosciences, medicinal agriculture and fundamental biomedical sciences sectors.Read moreRead less
Special Research Initiatives - Grant ID: SR0354696
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
ARC Research Network in Enterprise Information Infrastructure (EII). This research network targets investigation of Enterprise Computing and its infrastructure, with an emphasis on emerging advanced technologies and practices, for large-scale enterprises, government agencies and community groups. EII will bring together the best IT researchers, leading edge users and key IT technology providers to support consolidated, technically sound, integrated and strategically positioned research towards s ....ARC Research Network in Enterprise Information Infrastructure (EII). This research network targets investigation of Enterprise Computing and its infrastructure, with an emphasis on emerging advanced technologies and practices, for large-scale enterprises, government agencies and community groups. EII will bring together the best IT researchers, leading edge users and key IT technology providers to support consolidated, technically sound, integrated and strategically positioned research towards solutions for next generation Enterprise Computing. Web services, the Semantic Web and Service Oriented Computing are fast emerging new disciplines with far reaching impacts. EII will contribute to their growth and to their practical deployment in Australia and beyond. The establishment of EII network will dramatically add value to already supported but often fragmented research projects.Read moreRead less
ARC Research Network in Enterprise Information Infrastructure. EII targets consolidated research towards the comprehensive development & establishment of advanced information infrastructures. Its prime purpose is to provide a forum for intellectual exchange by diverse yet complementary research groups, to address the fundamental research problems faced by scientific & business communities when dealing with deployment of information technology to globally distributed, and data intensive environme ....ARC Research Network in Enterprise Information Infrastructure. EII targets consolidated research towards the comprehensive development & establishment of advanced information infrastructures. Its prime purpose is to provide a forum for intellectual exchange by diverse yet complementary research groups, to address the fundamental research problems faced by scientific & business communities when dealing with deployment of information technology to globally distributed, and data intensive environments. EII will address 3 tightly coupled research themes: Ability to interoperate across existing heterogenous platforms & applications; Efficient processing of very large data sets; Technology adoption & impact. Generic results will be applicable to e-science and large business information systems installations.Read moreRead less
An empirically-derived conceptual framework for designing usable and useful wireless mobile applications. The technological challenges posed by mobile computing devices have taken priority over the issues of appropriate use and usability that will ultimately determine their success in real work environments.
This project investigates these issues, particularly the role played by the context of use in the usability and usefulness of mobile applications.
The project's aims will be realised ....An empirically-derived conceptual framework for designing usable and useful wireless mobile applications. The technological challenges posed by mobile computing devices have taken priority over the issues of appropriate use and usability that will ultimately determine their success in real work environments.
This project investigates these issues, particularly the role played by the context of use in the usability and usefulness of mobile applications.
The project's aims will be realised through ethnographic studies of mobile work practice, representative use scenarios and the development of an empirically grounded conceptual framework that can guide the design of usable mobile applications.
The results will increase the successful utilisation of mobile technology by Australian industries.
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Gauging the value of flexible learning options for disenfranchised youth and the Australian community. Investment in flexible learning options (FLOs) for young people who have disengaged from schooling requires understanding of how they work and evidence about their economic and social value. This project will provide both through innovative and integrated methods, analysing FLO sites across three Australian states and the Northern Territory.
Implementing Indigenous knowledge approaches in doctoral education . This project aims to apply Indigenous knowledge approaches (agency of Country; power of stories and iterative, intergenerational and intercultural knowledge production) to Australian doctoral education. This project expects to generate new knowledge in the area of Indigenous and transcultural (migrant, refugee and international) doctoral education. Expected outcomes of the project include multimedia portal/app and policy recomm ....Implementing Indigenous knowledge approaches in doctoral education . This project aims to apply Indigenous knowledge approaches (agency of Country; power of stories and iterative, intergenerational and intercultural knowledge production) to Australian doctoral education. This project expects to generate new knowledge in the area of Indigenous and transcultural (migrant, refugee and international) doctoral education. Expected outcomes of the project include multimedia portal/app and policy recommendations for doctoral supervision, language and examination protocols that place Indigenous and transcultural knowledges at the forefront of Australian research. This should provide significant benefits to Australian higher education, enabling Australia to become a world leader in global knowledge production. Read moreRead less
Integrative assessment of disturbance and land-use change on total greenhouse gas balance and nutrient cycling in savanna ecosystems. Climate change and variability is expected to have an impact on the NT environment and economy. This project will enable NT specific calibrations of climate variability-land use models, such as the National Carbon Accounting System. The NT Government will have access to a high quality database and calibrated models relating to greenhouse gas emissions as a functio ....Integrative assessment of disturbance and land-use change on total greenhouse gas balance and nutrient cycling in savanna ecosystems. Climate change and variability is expected to have an impact on the NT environment and economy. This project will enable NT specific calibrations of climate variability-land use models, such as the National Carbon Accounting System. The NT Government will have access to a high quality database and calibrated models relating to greenhouse gas emissions as a function of land use change. The project will improve estimates and management of GHG and provide a basis for the NT to potentially exploit future carbon-trading initiatives or GHG abatement schemes as fundamental data describing emissions as a function of land use will be available. This is of national significance given the size of the savanna biome in Australia.Read moreRead less
Water-use efficiency of Australian tropical trees: mechanistic analysis at multiple scales. The proposed research will provide valuable information about the physiological functioning of trees in northern Australia. Experiments will elucidate mechanisms that can result in variation in water-use efficiency among different tree species. Such a mechanistic understanding will have multiple benefits: (1) results will be able to be incorporated into process-based models of carbon and water cycling ....Water-use efficiency of Australian tropical trees: mechanistic analysis at multiple scales. The proposed research will provide valuable information about the physiological functioning of trees in northern Australia. Experiments will elucidate mechanisms that can result in variation in water-use efficiency among different tree species. Such a mechanistic understanding will have multiple benefits: (1) results will be able to be incorporated into process-based models of carbon and water cycling in the north-Australian landscape; (2) they will provide valuable information for land managers interested in optimizing both plant biomass production and water resource management; and (3) they will provide a critical test of proxy methods for identifying high water-use efficiency in taxonomically diverse tree species.Read moreRead less