Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying ....Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying regulators of lipid metabolism. The large diversity in humans necessitate sufficient sample sizes to identify true genetic regulators, but to date techniques capturing phenotypic data (lipids) have been largely limited. It is anticipated that this study will identify new regulators of lipid metabolism in humans.Read moreRead less
Convex optimisation for control, signal processing and communication systems. Renewable control of complex systems, signal processing, telecommunication and in general any industries interested in these applications stand to benefit from our research. In particular, the automotive and defence industries stand to benefit from the nonlinear control design aspect of the proposed project outcomes. The
telecommunications industries, on the other hand, benefit from the signal processing and communicat ....Convex optimisation for control, signal processing and communication systems. Renewable control of complex systems, signal processing, telecommunication and in general any industries interested in these applications stand to benefit from our research. In particular, the automotive and defence industries stand to benefit from the nonlinear control design aspect of the proposed project outcomes. The
telecommunications industries, on the other hand, benefit from the signal processing and communications aspects. We also build a core expertise in optimisation and its applications in Australia by training PhD students and Postdoctoral researchers. The research collaborations will cement and maintain the international linkages which will improve applied research in AustraliaRead moreRead less
A Commercially Viable, Innovative XML - Enabled Association Rule Framework. The pervasive nature of the Web has raised two important issues, namely (1) how to exchange data between isolated information systems within two different companies with their own data formats and (2) how to store information particularly documents, so that they can be accessed through the internet based on their meaning. The Extended Markup Language XML has emerged as the favoured means of addressing these issues and th ....A Commercially Viable, Innovative XML - Enabled Association Rule Framework. The pervasive nature of the Web has raised two important issues, namely (1) how to exchange data between isolated information systems within two different companies with their own data formats and (2) how to store information particularly documents, so that they can be accessed through the internet based on their meaning. The Extended Markup Language XML has emerged as the favoured means of addressing these issues and this is leading to an explosive growth in the information stored in this way. This project addresses the issue of determination of patterns and knowledge in information stored in XML through datamining.Read moreRead less
Trans/national activism: Organizing for Domestic Worker Rights in Southeast Asia. This project will contribute to the identified national priority, Safeguarding Australia, by providing a better understanding of the issues surrounding labour migration, including the capacity of NGOs and state governments to address the needs and rights of labour migrants in Southeast Asia. By expanding our understanding of the possibilities for democratisation within the region and contributing to theoretical dev ....Trans/national activism: Organizing for Domestic Worker Rights in Southeast Asia. This project will contribute to the identified national priority, Safeguarding Australia, by providing a better understanding of the issues surrounding labour migration, including the capacity of NGOs and state governments to address the needs and rights of labour migrants in Southeast Asia. By expanding our understanding of the possibilities for democratisation within the region and contributing to theoretical developments on the relationship between state and civil society, this research will also contribute to the national interest in influencing institutional reform and democratic transition in Asia. Read moreRead less
CRISPR-based pathway activation for bioactive molecule discovery in fungi. Fungi produce an incredible array of unique bioactive molecules, many of which have contributed greatly to humanity (e.g. the antibiotic penicillin, which has saved millions of lives since its discovery). DNA sequencing has revealed many fungi contain the genetic instructions to produce new molecules that have not been seen previously. However, these genes are “switched off" by default and cannot be accessed. This project ....CRISPR-based pathway activation for bioactive molecule discovery in fungi. Fungi produce an incredible array of unique bioactive molecules, many of which have contributed greatly to humanity (e.g. the antibiotic penicillin, which has saved millions of lives since its discovery). DNA sequencing has revealed many fungi contain the genetic instructions to produce new molecules that have not been seen previously. However, these genes are “switched off" by default and cannot be accessed. This project will develop innovative new methods to "hot-wire" these genes, allowing them to turn on and produce a treasure trove of new bioactive molecules. The outcomes of this project will transform our abilities to tap into the hidden potential of fungi to generate new lead molecules for the agricultural and medical industries.Read moreRead less
Is transport of miRNAs essential for plant development? This project will provide knowledge of how a new class of biologically active molecule (micro RNA) regulates expression of genes at sites in the plant that are critical for growth and development. MicroRNAs are believed to influence the size and shape of plants, how rapidly they grow and how well they produce and fill seeds. These molecules are part of a group of bioactive signals that move throughout the plant, functioning like hormones bu ....Is transport of miRNAs essential for plant development? This project will provide knowledge of how a new class of biologically active molecule (micro RNA) regulates expression of genes at sites in the plant that are critical for growth and development. MicroRNAs are believed to influence the size and shape of plants, how rapidly they grow and how well they produce and fill seeds. These molecules are part of a group of bioactive signals that move throughout the plant, functioning like hormones but directly influencing how well critical genes work. Their exploitation holds great promise for manipulating plant performance and enhancing crop yields. Read moreRead less
Judges' work, place and psychological health - a national view. This project aims to address the human, juridical and financial costs of judicial officers’ work-related psychological harm. This harm is implicated in early retirement, sick leave and suicide. It threatens appropriate courtroom conduct, procedural fairness and impartial adjudication. The project seeks to generate new knowledge of the stress judicial officers experience and the individual and institutional mechanisms for managing st ....Judges' work, place and psychological health - a national view. This project aims to address the human, juridical and financial costs of judicial officers’ work-related psychological harm. This harm is implicated in early retirement, sick leave and suicide. It threatens appropriate courtroom conduct, procedural fairness and impartial adjudication. The project seeks to generate new knowledge of the stress judicial officers experience and the individual and institutional mechanisms for managing stressors, combining socio-legal and psychological approaches. Expected outcomes include evidence-based understandings to inform recruitment and retention strategies specific to this highly specialized workforce. This should provide significant benefits for judges’ work capacities and courts' delivery of justice.Read moreRead less
Listen and learn - statistical learning and the adapting auditory brain. This project aims to explore the link between rapid neural adaptation - a form of learning referred to as statistical learning - and human listening performance in noisy environments. The project aims to generate a new understanding of mechanisms that contribute to listeners' abilities to understand speech in noise, and to complex communication disorders such as dyslexia. Expected outcomes will include increased capacity to ....Listen and learn - statistical learning and the adapting auditory brain. This project aims to explore the link between rapid neural adaptation - a form of learning referred to as statistical learning - and human listening performance in noisy environments. The project aims to generate a new understanding of mechanisms that contribute to listeners' abilities to understand speech in noise, and to complex communication disorders such as dyslexia. Expected outcomes will include increased capacity to investigate a broad range of cognitive and communication functions. Benefits will include potential technologies and algorithms to assist listening (in devices such as hearing aids), language development and reading.Read moreRead less
Exploiting natural variation to discover tools to increase crop plant yield. This project aims to identify the specific biochemical and underlying molecular modifications that contributed to the evolution of the C4 pathway by studying C3, C4 and C3-C4 intermediate Flaveria species. Most land plants use C3 or C4 photosynthesis to assimilate CO2. Plants using the C4 pathway evolved from C3 ancestors in multiple plant lineages, and show higher rates of photosynthesis and conversion of solar radiati ....Exploiting natural variation to discover tools to increase crop plant yield. This project aims to identify the specific biochemical and underlying molecular modifications that contributed to the evolution of the C4 pathway by studying C3, C4 and C3-C4 intermediate Flaveria species. Most land plants use C3 or C4 photosynthesis to assimilate CO2. Plants using the C4 pathway evolved from C3 ancestors in multiple plant lineages, and show higher rates of photosynthesis and conversion of solar radiation to biomass in arid, high-light and saline environments, which are expanding due to global climate change. The outcomes of this project could define what is required to engineer plant varieties with increased yield and the ability to withstand effects of climate shift, and contribute to our understanding of convergent evolutionary processes.Read moreRead less
Female roles during postcopulatory sexual selection. The project will evaluate the importance of postcopulatory sexual selection in the guppy, a polyandrous species of livebearing fish. The use of artificial insemination, which experimentally controls the relative contribution of sperm from competing males (as well as other confounding effects), will facilitate a powerful test of recent theoretical predictions in evolutionary biology. The project will enable me to distinguish between competing h ....Female roles during postcopulatory sexual selection. The project will evaluate the importance of postcopulatory sexual selection in the guppy, a polyandrous species of livebearing fish. The use of artificial insemination, which experimentally controls the relative contribution of sperm from competing males (as well as other confounding effects), will facilitate a powerful test of recent theoretical predictions in evolutionary biology. The project will enable me to distinguish between competing hypotheses for postcopulatory paternity bias following female multiple mating (sperm competition, cryptic female choice, genetic compatibility) and provide additional insights into the selective forces promoting the evolution of female promiscuity.Read moreRead less