How does the noncoding genome regulate gene expression in the human brain? The non-coding genome is recognized as a major player in orchestrating gene expression in higher eukaryotes. This project aims to identify regions of the human genome that are important for gene expression during neuronal differentiation and depolarisation (i.e. neural enhancers), and to investigate their evolutionary properties. The roles of non-coding DNA in regulating the dynamic gene expression patterns underlying com ....How does the noncoding genome regulate gene expression in the human brain? The non-coding genome is recognized as a major player in orchestrating gene expression in higher eukaryotes. This project aims to identify regions of the human genome that are important for gene expression during neuronal differentiation and depolarisation (i.e. neural enhancers), and to investigate their evolutionary properties. The roles of non-coding DNA in regulating the dynamic gene expression patterns underlying complex human brain functions remains to be elucidated. By combining transcriptome quantification and bioinformatics methods, this project will close an important knowledge gap in our understanding of transcriptional regulation underlying human brain function. This will provide benefits such as the potential to influence public health policy including in cognitive functions and aging.Read moreRead less
Untangling environmental effects on bee health in the face of Varroa . This project aims to assess bee health, disease and evolution in European honeybees and bumblebees. Bee viruses transmitted by the destructive Varroa mite cause worldwide pollinator declines. Factors determining bee health will be identified across Australia, New Zealand and the United Kingdom, which differ in Varroa impact and bee introduction histories. Harnessing Australia’s currently threatened Varroa-free status, the bum ....Untangling environmental effects on bee health in the face of Varroa . This project aims to assess bee health, disease and evolution in European honeybees and bumblebees. Bee viruses transmitted by the destructive Varroa mite cause worldwide pollinator declines. Factors determining bee health will be identified across Australia, New Zealand and the United Kingdom, which differ in Varroa impact and bee introduction histories. Harnessing Australia’s currently threatened Varroa-free status, the bumblebee invasion in Tasmania, and cutting-edge multi-omics techniques (for microbiomes, viruses and genomes), predictors of disease dynamics will be identified for two globally important bee pollinators. The project outcomes will boost Australia's capacity to manage threats to pollination services at landscape scales.Read moreRead less
Elucidating the molecular mechanisms of dual function transporter/channels. This project aims to understand how a membrane protein that transports chemical messengers in the brain functions and how it is influenced by the membrane in which it is embedded. Cells from all life forms have a lipid membrane that separates them from their external environment. These membranes contain proteins that control the movements of molecules into and out of cells and are vital for a plethora of physiological pr ....Elucidating the molecular mechanisms of dual function transporter/channels. This project aims to understand how a membrane protein that transports chemical messengers in the brain functions and how it is influenced by the membrane in which it is embedded. Cells from all life forms have a lipid membrane that separates them from their external environment. These membranes contain proteins that control the movements of molecules into and out of cells and are vital for a plethora of physiological processes including cell-to-cell communication. The outcomes of this study will include new knowledge of this process and chemical modifiers of this transport protein. This project will benefit structural biology and biophysics training and may lead to the development of novel compounds that can be used to explore function. Read moreRead less
Targeting chloroplasts to enhance crop salt tolerance. Yield losses in crop plants due to increasingly saline soils are linked to the effects of salt on chloroplasts. By comparing chloroplast water- and salt-transport mechanisms of closely related salt-loving and salt-sensitive plants, this Fellowships aims to discover how chloroplasts maintain function in saline conditions. Novel biophysics and molecular techniques will be used to characterise transporters in model plants, and proof-of-concept ....Targeting chloroplasts to enhance crop salt tolerance. Yield losses in crop plants due to increasingly saline soils are linked to the effects of salt on chloroplasts. By comparing chloroplast water- and salt-transport mechanisms of closely related salt-loving and salt-sensitive plants, this Fellowships aims to discover how chloroplasts maintain function in saline conditions. Novel biophysics and molecular techniques will be used to characterise transporters in model plants, and proof-of-concept complementation experiments aim to confer salt tolerance on sensitive plants. These fundamental insights are likely to lead to rapid, step-change improvements in salt tolerance, especially in agriculturally relevant crops, to benefit Australia’s agri-industry and ensure food security in the future.Read moreRead less
Swarm construction: ant-inspired processes for teams of building robots. Construction and manufacturing can be dangerous, wasteful industries—prime candidates for automation by teams of mobile robot builders. However, our understanding of how to program robots for teamwork is limited. This project aims to understand how colonies of weaver ants build complex nest structures, using novel 3D-imaging and ant tracking techniques. The anticipated outcomes of the project are i) a framework for how indi ....Swarm construction: ant-inspired processes for teams of building robots. Construction and manufacturing can be dangerous, wasteful industries—prime candidates for automation by teams of mobile robot builders. However, our understanding of how to program robots for teamwork is limited. This project aims to understand how colonies of weaver ants build complex nest structures, using novel 3D-imaging and ant tracking techniques. The anticipated outcomes of the project are i) a framework for how individual-level behaviour drives structure-level outcomes, applicable to many complex systems, and ii) novel software and hardware for robot swarms that can 3D-print structures using ant inspired teamwork strategies. Benefits of the project include new construction technologies that are safer, greener, cheaper and faster.Read moreRead less
The red belly blockchain: a scalable blockchain for internet of things. This project aims to offer a blockchain that scales with the number of participants. There have been major investments in blockchain technologies during the last year as blockchains promise to disrupt industries like supply chains. Unfortunately, blockchains cannot solve this problem in their current form, because they cannot scale. They require resources that grow with the number of participants and yet fail at providing in ....The red belly blockchain: a scalable blockchain for internet of things. This project aims to offer a blockchain that scales with the number of participants. There have been major investments in blockchain technologies during the last year as blockchains promise to disrupt industries like supply chains. Unfortunately, blockchains cannot solve this problem in their current form, because they cannot scale. They require resources that grow with the number of participants and yet fail at providing increasing performance. The project will leverage many devices of limited resources to offer higher performance and will impact the distributed computing field by establishing a new connection between energy efficient systems and highly scalable distributed algorithms.Read moreRead less
Sensing biomechanical forces in the heart. Mechanosensitive ion channels are key molecules that define how each heart cell interacts with their physical environment. Yet how they enable cells to decode biomechanical cues remains poorly understood. At the heart of this problem is a lack of tools to quantify the force required for activation. This project aims to develop novel technologies to record the activity of these essential channels in a critical cell type within the heart, and use this inf ....Sensing biomechanical forces in the heart. Mechanosensitive ion channels are key molecules that define how each heart cell interacts with their physical environment. Yet how they enable cells to decode biomechanical cues remains poorly understood. At the heart of this problem is a lack of tools to quantify the force required for activation. This project aims to develop novel technologies to record the activity of these essential channels in a critical cell type within the heart, and use this information in addition to micro-engineering approaches to fully understand the role of these channels in force sensing and generation, at both the single cell and micro-tissue levels. This knowledge and technology has broad utility that extends far beyond cardiac biology into multiple fields.Read moreRead less
Electro-triggered solidification of supercooled fusible alloys. Stiffness is typically considered a static property of a material. Traditionally, once the stiffness is specified, it is not expected to change during operation. This project aims to turn a problem (i.e., supercooling) into an opportunity for creating fusible alloy composites with electroprogrammable stiffness that can outperform state-of-the-art materials by offering all desirable properties. Expected outcomes are the rapid, contin ....Electro-triggered solidification of supercooled fusible alloys. Stiffness is typically considered a static property of a material. Traditionally, once the stiffness is specified, it is not expected to change during operation. This project aims to turn a problem (i.e., supercooling) into an opportunity for creating fusible alloy composites with electroprogrammable stiffness that can outperform state-of-the-art materials by offering all desirable properties. Expected outcomes are the rapid, continuous, large, and reversible change in stiffness of the composite through electrical control. This project will provide significant benefits by enabling an increasing number of emerging applications in areas such as robotics, manufacturing, and consumer wearables that require materials with tuneable stiffness.Read moreRead less
Bias and allostery at the calcium sensing receptor. This project aims to provide a mechanistic and dynamic picture of the structure, function and physiology of the human calcium sensing receptor (CaSR), which is critical for vertebrate life. By responding to chemicals in the body, it acts as a universal nutrient sensor to maintain extracellular calcium homeostasis and mediate biological functions, including neurotransmission, inflammation, digestion, blood pressure and development. However, it i ....Bias and allostery at the calcium sensing receptor. This project aims to provide a mechanistic and dynamic picture of the structure, function and physiology of the human calcium sensing receptor (CaSR), which is critical for vertebrate life. By responding to chemicals in the body, it acts as a universal nutrient sensor to maintain extracellular calcium homeostasis and mediate biological functions, including neurotransmission, inflammation, digestion, blood pressure and development. However, it is not known how this single receptor controls the actions of multiple ligands to mediate numerous functions. By elucidating the roles of the CaSR and its ligands, this project aims to better understand fundamental physiological processes.Read moreRead less
All-Sky Exoplanetology using NASA's Kepler, K2 and TESS Missions. The NASA space missions Kepler, K2 and TESS have revolutionized astronomy over the past decade through the discovery of thousands of planets orbiting other stars. This project will for the first time combine the data from these missions to perform a homogeneous all-sky characterization of exoplanets and their host stars, and perform follow-up observations using ground-based telescopes to precisely determine masses and architecture ....All-Sky Exoplanetology using NASA's Kepler, K2 and TESS Missions. The NASA space missions Kepler, K2 and TESS have revolutionized astronomy over the past decade through the discovery of thousands of planets orbiting other stars. This project will for the first time combine the data from these missions to perform a homogeneous all-sky characterization of exoplanets and their host stars, and perform follow-up observations using ground-based telescopes to precisely determine masses and architectures of exoplanet systems. The expected outcomes include the first insights into how the radius distribution of small exoplanets varies among different populations of stars in our Galaxy, and breakthrough discoveries into the formation, composition, and evolution of giant exoplanets.
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